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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Trigonella


High impact information on Trigonella

  • The topology of these reactions is not known, although the orientation of a plant galactosyltransferase involved in the biosynthesis of galactomannans in fenugreek is consistent with a requirement for UDP-galactose in the lumen of the Golgi cisternae [6].
  • Fenugreek (Trigonella foenum-graecum) forms a galactomannan with a very high degree of Gal substitution (Man/Gal = 1.1), and its GMGT has been characterized [7].
  • Tobacco transgenic lines that express fenugreek galactomannan galactosyltransferase constitutively have structurally altered galactomannans in their seed endosperm cell walls [7].
  • We evaluated the preventive efficacy of dietary fenugreek seed and its major steroidal saponin constituent, diosgenin, on azoxymethane-induced rat colon carcinogenesis during initiation and promotion stages [2].
  • Trigonella foenum graecum (fenugreek) is traditionally used to treat disorders such as diabetes, high cholesterol, wounds, inflammation, and gastrointestinal ailments [2].

Chemical compound and disease context of Trigonella


Biological context of Trigonella


Anatomical context of Trigonella


Associations of Trigonella with chemical compounds

  • Furthermore, we demonstrate that seeds from transgenic tobacco lines that express fenugreek GMGT constitutively in membrane-bound form have endosperm galactomannans with increased average degrees of Gal substitution (Man/Gal about 10 in T(1) generation seeds and about 7.5 in T(2) generation seeds) [7].
  • Transfer specificity of detergent-solubilized fenugreek galactomannan galactosyltransferase [16].
  • We have recently shown that a fenugreek seed extract containing steroid saponins increased food consumption and induced hypocholesterolemia in rats [17].
  • For detecting IgE binding by immunoblotting method, the proteins of the fenugreek extract were resolved using sodium dodecyl sulphate polyacrylamide gel electrophoresis [18].
  • The present study explored the prospect of using low doses of vanadate in combination with Trigonella seed powder (TSP) to evaluate their antidiabetic effect in alloxan-diabetic rats [19].

Gene context of Trigonella

  • Significant elevation of catalase activity was observed with a 10% dose of fenugreek [14].
  • Dietary administration of fenugreek seeds resulted in an increase of GSH levels and the glutathione S-transferase (GST) activity in the liver [14].
  • Inclusion of fenugreek to the meal tolerance test given to NIDDM also decreased the postprandial blood glucose levels [20].
  • Addition of powdered fenugreek to an oral glucose tolerance test significantly reduced the subsequent postprandial blood glucose level in diabetic rats [20].
  • The present study explored the prospect of using low doses of vanadate with Trigonella foenum graecum, seed powder (TSP), another antidiabetic agent, and to evaluate their antidiabetic effect in diabetic rats [21].

Analytical, diagnostic and therapeutic context of Trigonella


  1. Transglycosylation reactions catalysed by two beta-mannanases. Coulombel, C., Clermont, S., Foglietti, M.J., Percheron, F. Biochem. J. (1981) [Pubmed]
  2. Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells. Raju, J., Patlolla, J.M., Swamy, M.V., Rao, C.V. Cancer Epidemiol. Biomarkers Prev. (2004) [Pubmed]
  3. Fenugreek (trigonella foenum graecum) seed extract prevents ethanol-induced toxicity and apoptosis in chang liver cells. Kaviarasan, S., Ramamurty, N., Gunasekaran, P., Varalakshmi, E., Anuradha, C.V. Alcohol Alcohol. (2006) [Pubmed]
  4. Antagonism of cadmium and alloxan-induced hyperglycemia in rats by Trigonella foenum graecum. Ghafghazi, T., Sheriat, H.S., Dastmalchi, T., Barnett, R.C. Pahlavi medical journal. (1977) [Pubmed]
  5. Gastroprotective effect of fenugreek seeds (Trigonella foenum graecum) on experimental gastric ulcer in rats. Pandian, R.S., Anuradha, C.V., Viswanathan, P. Journal of ethnopharmacology. (2002) [Pubmed]
  6. Transport of UDP-galactose in plants. Identification and functional characterization of AtUTr1, an Arabidopsis thaliana UDP-galactos/UDP-glucose transporter. Norambuena, L., Marchant, L., Berninsone, P., Hirschberg, C.B., Silva, H., Orellana, A. J. Biol. Chem. (2002) [Pubmed]
  7. Tobacco transgenic lines that express fenugreek galactomannan galactosyltransferase constitutively have structurally altered galactomannans in their seed endosperm cell walls. Reid, J.S., Edwards, M.E., Dickson, C.A., Scott, C., Gidley, M.J. Plant Physiol. (2003) [Pubmed]
  8. Modulation of some gluconeogenic enzyme activities in diabetic rat liver and kidney: effect of antidiabetic compounds. Gupta, D., Raju, J., Baquer, N.Z. Indian J. Exp. Biol. (1999) [Pubmed]
  9. Microdetermination of diosgenin from fenugreek (Trigonella foenum-graecum) seeds. Taylor, W.G., Elder, J.L., Chang, P.R., Richards, K.W. J. Agric. Food Chem. (2000) [Pubmed]
  10. Trigonellafoenum graecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes. Raju, J., Gupta, D., Rao, A.R., Yadava, P.K., Baquer, N.Z. Mol. Cell. Biochem. (2001) [Pubmed]
  11. Restoration on tissue antioxidants by fenugreek seeds (Trigonella Foenum Graecum) in alloxan-diabetic rats. Anuradha, C.V., Ravikumar, P. Indian J. Physiol. Pharmacol. (2001) [Pubmed]
  12. Supplementation of fenugreek leaves reduces oxidative stress in streptozotocin-induced diabetic rats. Annida, B., Stanely Mainzen Prince, P. Journal of medicinal food. (2005) [Pubmed]
  13. Implication of steroid saponins and sapogenins in the hypocholesterolemic effect of fenugreek. Sauvaire, Y., Ribes, G., Baccou, J.C., Loubatieères-Mariani, M.M. Lipids (1991) [Pubmed]
  14. Modulation of glyoxalase, glutathione S-transferase and antioxidant enzymes in the liver, spleen and erythrocytes of mice by dietary administration of fenugreek seeds. Choudhary, D., Chandra, D., Choudhary, S., Kale, R.K. Food Chem. Toxicol. (2001) [Pubmed]
  15. Uptake of 45Ca by mitochondria of Trigonella foenum-graecum as influenced by selenium and mimosine--detailed kinetic analyses. Sreekala, M., Lalitha, K. Biological trace element research. (2001) [Pubmed]
  16. Transfer specificity of detergent-solubilized fenugreek galactomannan galactosyltransferase. Edwards, M.E., Marshall, E., Gidley, M.J., Reid, J.S. Plant Physiol. (2002) [Pubmed]
  17. Steroid saponins from fenugreek seeds: extraction, purification, and pharmacological investigation on feeding behavior and plasma cholesterol. Petit, P.R., Sauvaire, Y.D., Hillaire-Buys, D.M., Leconte, O.M., Baissac, Y.G., Ponsin, G.R., Ribes, G.R. Steroids (1995) [Pubmed]
  18. Allergy to fenugreek (Trigonella foenum graecum). Patil, S.P., Niphadkar, P.V., Bapat, M.M. Ann. Allergy Asthma Immunol. (1997) [Pubmed]
  19. Modulation of glucose transporter (GLUT4) by vanadate and Trigonella in alloxan-diabetic rats. Mohammad, S., Taha, A., Bamezai, R.N., Baquer, N.Z. Life Sci. (2006) [Pubmed]
  20. New sources of dietary fibre. Madar, Z. International journal of obesity. (1987) [Pubmed]
  21. Low doses of vanadate and Trigonella synergistically regulate Na(+)/K (+)-ATPase activity and GLUT4 translocation in alloxan-diabetic rats. Siddiqui, M.R., Moorthy, K., Taha, A., Hussain, M.E., Baquer, N.Z. Mol. Cell. Biochem. (2006) [Pubmed]
  22. Oral administration of orthovanadate and Trigonella foenum graecum seed power restore the activities of mitochondrial enzymes in tissues of alloxan-induced diabetic rats. Thakran, S., Salimuddin, n.u.l.l., Baquer, N.Z. Mol. Cell. Biochem. (2003) [Pubmed]
  23. Sotolone production by hairy root cultures of Trigonella foenum-graecum in airlift with mesh bioreactors. Peraza-Luna, F., Rodríguez-Mendiola, M., Arias-Castro, C., Bessiere, J.M., Calva-Calva, G. J. Agric. Food Chem. (2001) [Pubmed]
  24. Inhibitors of human and bovine trypsin and chymotrypsin in fenugreek (Trigonella foenum-graecum L.) seeds. Demonstration and purification. Weder, J.K., Haussner, K. Zeitschrift für Lebensmittel-Untersuchung und -Forschung. (1991) [Pubmed]
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