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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Urinary Retention

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Disease relevance of Urinary Retention


High impact information on Urinary Retention


Chemical compound and disease context of Urinary Retention


Biological context of Urinary Retention

  • When given intrathecally in increasing doses, both muscimol (1 to 10 micrograms) and baclofen (0.1 to 5 micrograms) produced a dose-dependent inhibition of micturition with progressive increases in bladder capacity and residual volume, and a decrease in micturition pressure ending with urinary retention and dribbling incontinence [15].
  • CONCLUSION: Glycine infusions might improve the contractile responses of bladder smooth muscle after acute urinary retention by reducing oxidative damage and apoptosis [16].
  • Although the effect of prostaglandin F2 alpha on bladder muscle contraction was short-lived, it seemed to enhance the restoration of bladder motor function with no serious side effects, and thus to be clinically useful in the treatment of post-operative urinary retention [17].
  • CONCLUSION: A single intraoperative dose of i.v. ketorolac appears to be opioid dose sharing, to provide superior analgesia, and to decrease the frequency of urinary retention during the first 12 hours of postoperative pediatric PCA with morphine [18].

Anatomical context of Urinary Retention


Gene context of Urinary Retention

  • A 71-year-old man experienced gradually progressive leg weakness, urinary retention, and mild loss of sensation in dermatomes T8 through T12 bilaterally [23].
  • We recently treated a number of patients with markedly elevated prostate specific antigen (PSA) levels associated with acute urinary retention in a post-cardiac surgery setting [24].
  • Nerve sparing extravesical repair of bilateral vesicoureteral reflux: description of technique and evaluation of urinary retention [25].
  • CONCLUSIONS: Alpha-blocker therapy seems to be a viable alternative to biofeedback in dysfunctional voiding in children with urinary retention to improve bladder emptying [26].
  • Acute urinary retention associated with the use of cyclooxygenase-2 inhibitors [27].

Analytical, diagnostic and therapeutic context of Urinary Retention


  1. Relapsing transverse myelitis. Tippett, D.S., Fishman, P.S., Panitch, H.S. Neurology (1991) [Pubmed]
  2. Management of benign prostatic hyperplasia by transurethral laser ablation in patients treated with warfarin anticoagulation. Bolton, D.M., Costello, A.J. J. Urol. (1994) [Pubmed]
  3. Holmium laser enucleation for prostate adenoma greater than 100 gm.: comparison to open prostatectomy. Moody, J.A., Lingeman, J.E. J. Urol. (2001) [Pubmed]
  4. Androgen receptor gene amplification and protein expression in recurrent prostate cancer. Ford, O.H., Gregory, C.W., Kim, D., Smitherman, A.B., Mohler, J.L. J. Urol. (2003) [Pubmed]
  5. Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. Oesterling, J.E. J. Urol. (1991) [Pubmed]
  6. Detrusor hyperactivity with impaired contractile function. An unrecognized but common cause of incontinence in elderly patients. Resnick, N.M., Yalla, S.V. JAMA (1987) [Pubmed]
  7. Nicardipine and urinary retention. Eicher, J.C., Chalopin, J.M., Tanter, Y., Louis, P., Rifle, G. JAMA (1987) [Pubmed]
  8. An epidemic of urinary retention caused by dimethylaminopropionitrile. Keogh, J.P., Pestronk, A., Wertheimer, D., Moreland, R. JAMA (1980) [Pubmed]
  9. Intravenous acyclovir for the treatment of primary genital herpes. Corey, L., Fife, K.H., Benedetti, J.K., Winter, C.A., Fahnlander, A., Connor, J.D., Hintz, M.A., Holmes, K.K. Ann. Intern. Med. (1983) [Pubmed]
  10. Theophylline-induced urinary retention. Owens, G.R., Tannenbaum, R. Ann. Intern. Med. (1981) [Pubmed]
  11. Urinary retention as a possible complication of long-term diazepam abuse. Maany, I., Greenfield, H., Dhopesh, V., Woody, G. The American journal of psychiatry. (1991) [Pubmed]
  12. Aggravated CNS depression with urinary retention secondary to baclofen administration. White, W.B. Arch. Intern. Med. (1985) [Pubmed]
  13. Development of urinary retention during treatment with clozapine and meclizine. Cohen, M.A., Alfonso, C.A., Mosquera, M. The American journal of psychiatry. (1994) [Pubmed]
  14. Urinary retention as a result of administration of terfenadine. Seggev, J.S., Fink, J.N. J. Allergy Clin. Immunol. (1994) [Pubmed]
  15. Effects of GABA-receptor stimulation and blockade on micturition in normal rats and rats with bladder outflow obstruction. Igawa, Y., Mattiasson, A., Andersson, K.E. J. Urol. (1993) [Pubmed]
  16. Effect of glycine on recovery of bladder smooth muscle contractility after acute urinary retention in rats. Hong, S.K., Son, H., Kim, S.W., Oh, S.J., Choi, H. BJU international. (2005) [Pubmed]
  17. Intravesical prostaglandin F2 for promoting bladder emptying after surgery for female stress incontinence. Tammela, T., Kontturi, M., Käär, K., Lukkarinen, O. British journal of urology. (1987) [Pubmed]
  18. Intravenous ketorolac as an adjuvant to pediatric patient-controlled analgesia with morphine. Vetter, T.R., Heiner, E.J. Journal of clinical anesthesia. (1994) [Pubmed]
  19. Urinary retention induced by estrogen injections in mice: an analytical model. Kuroda, H., Kohrogi, T., Uchida, N., Imai, I., Terada, N., Matsumoto, K., Kitamura, Y. J. Urol. (1985) [Pubmed]
  20. Dose-response effect of intrathecal alfentanil on canine lower urinary tract dynamics. Drenger, B., Sughayer, H., Chrubasik, J., Hoffman, A., Goldofsky, S., Magora, F. Anesth. Analg. (1993) [Pubmed]
  21. Acute urinary retention after gonadotropin-releasing hormone agonist treatment for leiomyomata uteri. Friedman, A.J. Fertil. Steril. (1993) [Pubmed]
  22. Venlafaxine and bladder function. Inghilleri, M., Conte, A., Frasca, V., Bettolo, C.M., Iacovelli, E., Aragona, M., Carbone, A., Prencipe, M. Clinical neuropharmacology. (2005) [Pubmed]
  23. Nonhemorrhagic venous infarction of the spinal cord. Kim, R.C., Smith, H.R., Henbest, M.L., Choi, B.H. Ann. Neurol. (1984) [Pubmed]
  24. Nontraumatic elevation of prostate specific antigen following cardiac surgery and extracorporeal cardiopulmonary bypass. Hagood, P.G., Parra, R.O., Rauscher, J.A. J. Urol. (1994) [Pubmed]
  25. Nerve sparing extravesical repair of bilateral vesicoureteral reflux: description of technique and evaluation of urinary retention. David, S., Kelly, C., Poppas, D.P. J. Urol. (2004) [Pubmed]
  26. Can alpha-blocker therapy be an alternative to biofeedback for dysfunctional voiding and urinary retention? A prospective study. Yucel, S., Akkaya, E., Guntekin, E., Kukul, E., Akman, S., Melikoglu, M., Baykara, M. J. Urol. (2005) [Pubmed]
  27. Acute urinary retention associated with the use of cyclooxygenase-2 inhibitors. Gruenenfelder, J., McGuire, E.J., Faerber, G.J. J. Urol. (2002) [Pubmed]
  28. Prophylactic tamsulosin (Flomax) in patients undergoing prostate 125I brachytherapy for prostate carcinoma: final report of a double-blind placebo-controlled randomized study. Elshaikh, M.A., Ulchaker, J.C., Reddy, C.A., Angermeier, K.W., Klein, E.A., Chehade, N., Altman, A., Ciezki, J.P. Int. J. Radiat. Oncol. Biol. Phys. (2005) [Pubmed]
  29. A randomized study to compare biodegradable self-reinforced polyglycolic acid spiral stents to suprapubic and indwelling catheters after visual laser ablation of the prostate. Pétas, A., Talja, M., Tammela, T., Taari, K., Lehtoranta, K., Välimaa, T., Törmälä, P. J. Urol. (1997) [Pubmed]
  30. Prostate cancer detection in candidates for open prostatectomy. Fowler, J.E., Bigler, S.A., Kolski, J.M. J. Urol. (1998) [Pubmed]
  31. Low-dose naloxone in the treatment of urinary retention during extradural fentanyl causes excessive reversal of analgesia. Wang, J., Pennefather, S., Russell, G. British journal of anaesthesia. (1998) [Pubmed]
  32. Prostaglandin F2 alpha for prevention of urinary retention after vaginal hysterectomy. Jaschevatzky, O.E., Anderman, S., Shalit, A., Ellenbogen, A., Grunstein, S. Obstetrics and gynecology. (1985) [Pubmed]
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