Disease relevance of Sterculia

• Although most indications for the use of such remedies are anecdotally or traditionally derived, controlled trials suggest some benefits for ginger in nausea and vomiting, liquorice extracts in peptic ulceration, Chinese herbal medicine in irritable bowel syndrome, opium derivatives in diarrhoea and senna, ispaghula and sterculia in constipation [1].
• Salicylic acid in karaya gum patch as a treatment for verruca vulgaris [2].

High impact information on Sterculia

• Sterculia foetida seed oil contains 65-78% CPE-FAs, principally sterculic acid [3].
• Cyclopropane synthase from Sterculia foetida developing seeds catalyzes the addition of a methylene group from S-adenosylmethionine to the cis double bond of oleic acid (Bao, X., Katz, S., Pollard, M., and Ohlrogge, J. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 7172-7177) [4].
• Characterization of cyclopropane fatty-acid synthase from Sterculia foetida [4].
• Results from dialysis and fermentation predicted the action of wheat bran, pectin, guar, gum arabic, carboxymethylcellulose, gellan, tragacanth, xanthan, and karaya in humans and generated anomalous results for karaya and tragacanth [5].
• Other fiber sources like gum karaya have no effect on stool weight, serum cholesterol, or breath hydrogen [6].

Anatomical context of Sterculia

• In trypsinized, subcultured rabbit aortic smooth muscle cells, Sterculia foetida seed oil extract resulted in an increased incorporation of (3H) thymidine per milligram of protein [7].

Associations of Sterculia with chemical compounds

• Four refined fibers, cellulose, carboxymethylcellulose gum, locust bean gum, or karaya gum, were added to the basal diet individually for 4 wk each at the level of 0.75 g fiber/100 cal [8].
• Sterculia foetida oil (50% cyclopropene fatty acids) fed at 0.2% of the diet for three generations and 0.5% fed to first generation rats did not significantly affect breeding [9].
• Seventeen patients received wheat fiber; 13 were given a laxative regime of sterculia, magnesium sulfate, and mineral oil [10].
• Cyclopropenoid fatty acids (CPE) isolated from Sterculia foetida oil by urea clathration and reverse phase high performance liquid chromatography (HPLC) were introduced into fungal cultures [11].
• The absence of rhamnose in human urine following the ingestion of gum karaya (Sterculia) [12].

Gene context of Sterculia

• Urinary rhamnose estimations following ingestion of gum karaya were requested by the Scientific Committee for Food (EEC) in July 1983 [12].

Analytical, diagnostic and therapeutic context of Sterculia

• Cyclopropenoids fatty acids (CPFA) from Sterculia striata seed oil were characterized by gas chromatography/mass spectrometry (GC/MS) and quantified by gas chromatography-flame ionization detector (GC-FID) after derivation to fatty acid methyl esters using a cold base-catalyzed procedure [13].

References