Disease relevance of C08366

• Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo [1].
• In vitro effects of sterculic acid on lipid biosynthesis in Rhodococcus opacus strain PD630 and isolation of mutants defective in fatty acid desaturation [2].

High impact information on C08366

• Injection of 750 micrograms SA reduced serum concentrations of P4 and shortened estrous cycle duration (P less than 0.005) [3].
• It is concluded that SA acts on the CL to impair steroidogenesis and ultimately cause luteal regression [3].
• Either 1.09 mg of an extract of Sterculia foetida seeds, containing 750 micrograms sterculic acid methyl ester (SA, n = 6), or 1.09 mg oleic acid methyl ester (OA, n = 6) was injected into the artery supplying the ovary bearing CL [4].
• Female F344 rats were injected subcutaneously with two different doses of sterculic acid for 4 weeks prior to, and 4 weeks following, implantation of a nitrosomethylurea-induced mammary tumour [1].
• Commentary on F.E. Gomez et al., "Effects of sterculic acid on stearoyl-CoA desaturase in differentiating 3T3-L1 adipocytes" [5].

Biological context of C08366

• The accumulation of 16:0 and 18:0, together with normal levels of fatty acid synthase (FAS) and aP2 mRNAs, shows that de novo synthesis and elongation of fatty acids, as well as cell differentiation, were not affected by sterculic acid [6].
• These results indicate that sterculic acid directly inhibits SCD activity, possibly by a turnover-dependent reaction, without affecting the processes required for adipocyte differentiation, scd gene expression or SCD protein translation [6].
• The effects of sterculic acid on cell size, adiposity, and fatty acid composition of differentiating 3T3-L1 adipocytes are correlated with stearoyl-CoA desaturase (SCD) expression (mRNA and protein levels) and enzyme activity [6].

Anatomical context of C08366

• When liver microsomes prepared from rats fed the control diet were used for the desaturation assays, the presence of free malvalic or sterculic acid in the medium, also highly depressed delta 6- and delta 5-desaturation [7].

Associations of C08366 with other chemical compounds

• Fluorescence-activated cell scanning (FACS) analysis showed that adipocytes differentiated with methylisobutylxanthine, dexamethasone, and insulin (MDI) plus 100 microM sterculic acid comprised a population of predominantly large cells with reduced adiposity compared to MDI-treated cells [6].
• Using autoradiography following a (3H) thymidine pulse, the percentage of labeled cells was increased in the sterculic acid triglyceride treated groups, as compared to controls [8].

References