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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Larrea

  • Oenothera rosea methanol extract, Sphaeralcea angustifolia chloroform extract, Acaciafarnesiana, Larrea tridentata and Rubus coriifolius methanol extracts as well as the aqueous extract of Chamaedora tepejilote were demonstrated to be particularly active against the induced hind-paw edema [1].

High impact information on Larrea

  • An enantio-specific polyphenol oxidase (PPO) was purified approximately 1,700-fold to apparent homogeneity from the creosote bush (Larrea tridentata), and its encoding gene was cloned [2].
  • A WRKY gene from creosote bush encodes an activator of the abscisic acid signaling pathway [3].
  • Chemically synthesized 3'-O-methyl-NDGA ((+/-)-2) showed identical anti-HIV activity (IC50 25 microM) to the lignan isolated from Creosote Bush [4].
  • Masoprocol (nordihydroguaiaretic acid), a lipoxygenase inhibitor isolated from the creosote bush, has been shown to decrease adipose tissue lipolytic activity both in vivo and in vitro [5].
  • We investigated the relationships between foliar stable carbon isotope discrimination (Delta), % foliar N, and predawn water potentials (psi(pd)) and midday stomatal conductance ( g(s)) of Larrea tridentata across five Mojave Desert soils with different age-specific surface and sub-surface horizon development and soil hydrologies [6].

Anatomical context of Larrea

  • We previously reported that aqueous extract of Larrea divaricata Cav. had an antiproliferative activity upon tumoral lymphoid cells (BW 5147), without affecting normal immunity [7].

Associations of Larrea with chemical compounds


Gene context of Larrea


  1. Activity of some Mexican medicinal plant extracts on carrageenan-induced rat paw edema. Meckes, M., David-Rivera, A.D., Nava-Aguilar, V., Jimenez, A. Phytomedicine (2004) [Pubmed]
  2. (+)-Larreatricin hydroxylase, an enantio-specific polyphenol oxidase from the creosote bush (Larrea tridentata). Cho, M.H., Moinuddin, S.G., Helms, G.L., Hishiyama, S., Eichinger, D., Davin, L.B., Lewis, N.G. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. A WRKY gene from creosote bush encodes an activator of the abscisic acid signaling pathway. Zou, X., Seemann, J.R., Neuman, D., Shen, Q.J. J. Biol. Chem. (2004) [Pubmed]
  4. Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation. Hwu, J.R., Tseng, W.N., Gnabre, J., Giza, P., Huang, R.C. J. Med. Chem. (1998) [Pubmed]
  5. Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL. Gowri, M.S., Azhar, R.K., Kraemer, F.B., Reaven, G.M., Azhar, S. Am. J. Physiol. Endocrinol. Metab. (2000) [Pubmed]
  6. Carbon isotope discrimination and foliar nutrient status of Larrea tridentata (creosote bush) in contrasting Mojave Desert soils. Hamerlynck, E.P., Huxman, T.E., McAuliffe, J.R., Smith, S.D. Oecologia (2004) [Pubmed]
  7. "In vivo" and "in vitro" antitumoral action of Larrea divaricata Cav. Anesini, C., Genaro, A., Cremaschi, G., Zubillaga, M., Boccio, J., Sterin-Borda, L., Borda, E. Acta physiologica, pharmacologica et therapeutica latinoamericana : órgano de la Asociación Latinoamericana de Ciencias Fisiológicas y [de] la Asociación Latinoamericana de Farmacología. (1996) [Pubmed]
  8. Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata). Luo, J., Chuang, T., Cheung, J., Quan, J., Tsai, J., Sullivan, C., Hector, R.F., Reed, M.J., Meszaros, K., King, S.R., Carlson, T.J., Reaven, G.M. Eur. J. Pharmacol. (1998) [Pubmed]
  9. Cytotoxic and other metabolites of Aspergillus inhabiting the rhizosphere of Sonoran desert plants. He, J., Wijeratne, E.M., Bashyal, B.P., Zhan, J., Seliga, C.J., Liu, M.X., Pierson, E.E., Pierson, L.S., VanEtten, H.D., Gunatilaka, A.A. J. Nat. Prod. (2004) [Pubmed]
  10. Masoprocol decreases serum triglyceride concentrations in rats with fructose-induced hypertriglyceridemia. Scribner, K.A., Gadbois, T.M., Gowri, M., Azhar, S., Reaven, G.M. Metab. Clin. Exp. (2000) [Pubmed]
  11. Inhibitory effect of nordihydroguaiaretic acid on the frequency of micronuclei induced by methyl methanesulfonate in vivo. Díaz Barriga, S., Madrigal-Bujaidar, E., Márquez, P. Mutat. Res. (1999) [Pubmed]
  12. Antioxidant lignans from Larrea tridentata. Abou-Gazar, H., Bedir, E., Takamatsu, S., Ferreira, D., Khan, I.A. Phytochemistry (2004) [Pubmed]
  13. Detoxification in relation to toxin tolerance in desert woodrats eating creosote bush. Mangione, A.M., Dearing, D., Karasov, W. J. Chem. Ecol. (2001) [Pubmed]
  14. Effect of Larrea divaricata Cav. extract and nordihydroguaiaretic acid upon peroxidase secretion in rat submandibulary glands. Anesini, C., Turner, S., Borda, E., Ferraro, G., Coussio, J. Pharmacol. Res. (2004) [Pubmed]
  15. Antimitogenic effect of Larrea divaricata Cav.: participation in arachidonate metabolism. Anesini, C., Genaro, A., Cremaschi, G., Sterin Borda, L., Borda, E. Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. (1999) [Pubmed]
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