Gene Review:
MUC16 - mucin 16, cell surface associated
Homo sapiens
Synonyms:
CA-125, CA125, FLJ14303, MUC-16, Mucin-16, ...
Aragonés,
Shigemasa,
Millá,
García,
Ho,
Tanaka,
Murdoch,
Mate,
O'Brien,
Warshaw,
Yilmaz,
Minguella,
Varela,
Beard,
del Castillo,
Chen,
Kufe,
Ng,
Dennis,
Erbağci,
Rivas,
García-Tirado,
López-Abente,
Cannistra,
O'Brien,
Lu,
Canalís,
Nikrui,
Zhang,
de la Torre,
Pollán,
González-Sarmiento,
Ortega,
Arnedillo,
Kudryashov,
Sebastián,
Torres,
Gómez,
Jacobs,
Skates,
Li,
Pac,
Gómez,
Yeung,
Avigan,
Fernández-Avilés,
Santin,
Batlle,
Yin,
Koido,
Rojas,
York,
Ribera,
Bast,
Atkinson,
Díez,
Marquez,
Underwood,
Regan,
Lewandrowski,
Flores,
Lee-Lewandrowski,
Rosen,
Lu,
Liu,
Badgwell,
Gong,
Ludeña,
Underwood,
Centeno,
Gipson,
Argüeso,
Martinchick,
Kutlar,
Arrabal,
Brugge,
Feliu,
Beard,
Lloyd,
Pérez-Gómez,
Oriol,
Freixenet,
Baggerly,
Menon,
Hori,
Wu,
Lokshin,
Laird,
Szydlo,
Pastor,
- Solution structure of the SEA domain from the murine homologue of ovarian cancer antigen CA125 (MUC16). Maeda, T., Inoue, M., Koshiba, S., Yabuki, T., Aoki, M., Nunokawa, E., Seki, E., Matsuda, T., Motoda, Y., Kobayashi, A., Hiroyasu, F., Shirouzu, M., Terada, T., Hayami, N., Ishizuka, Y., Shinya, N., Tatsuguchi, A., Yoshida, M., Hirota, H., Matsuo, Y., Tani, K., Arakawa, T., Carninci, P., Kawai, J., Hayashizaki, Y., Kigawa, T., Yokoyama, S. J. Biol. Chem. (2004)
- Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors. Gubbels, J.A., Belisle, J., Onda, M., Rancourt, C., Migneault, M., Ho, M., Bera, T.K., Connor, J., Sathyanarayana, B.K., Lee, B., Pastan, I., Patankar, M.S. Mol. Cancer (2006)
- Character of ocular surface mucins and their alteration in dry eye disease. Gipson, I.K., Hori, Y., Argüeso, P. The ocular surface (2004)
- Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. Yin, B.W., Lloyd, K.O. J. Biol. Chem. (2001)
- Successful eradication of established peritoneal ovarian tumors in SCID-Beige mice following adoptive transfer of T cells genetically targeted to the MUC16 antigen. Chekmasova, A.A., Rao, T.D., Nikhamin, Y., Park, K.J., Levine, D.A., Spriggs, D.R., Brentjens, R.J. Clin. Cancer Res. (2010)
- Risk-reducing surgery, screening and chemoprevention practices of BRCA1 and BRCA2 mutation carriers: a prospective cohort study. Phillips, K.A., Jenkins, M.A., Lindeman, G.J., McLachlan, S.A., McKinley, J.M., Weideman, P.C., Hopper, J.L., Friedlander, M.L. Clin. Genet. (2006)
- Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study. Brugge, W.R., Lewandrowski, K., Lee-Lewandrowski, E., Centeno, B.A., Szydlo, T., Regan, S., del Castillo, C.F., Warshaw, A.L. Gastroenterology (2004)
- Application of Bayesian modeling of autologous antibody responses against ovarian tumor-associated antigens to cancer detection. Erkanli, A., Taylor, D.D., Dean, D., Eksir, F., Egger, D., Geyer, J., Nelson, B.H., Stone, B., Fritsche, H.A., Roden, R.B. Cancer Res. (2006)
- A genetically defined model for human ovarian cancer. Liu, J., Yang, G., Thompson-Lanza, J.A., Glassman, A., Hayes, K., Patterson, A., Marquez, R.T., Auersperg, N., Yu, Y., Hahn, W.C., Mills, G.B., Bast, R.C. Cancer Res. (2004)
- Discovery and validation of new molecular targets for ovarian cancer. Hu, X.F., Xing, P.X. Curr. Opin. Mol. Ther. (2003)
- Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125. Kui Wong, N., Easton, R.L., Panico, M., Sutton-Smith, M., Morrison, J.C., Lattanzio, F.A., Morris, H.R., Clark, G.F., Dell, A., Patankar, M.S. J. Biol. Chem. (2003)
- Minimal deviation adenocarcinoma of the uterine cervix has abnormal expression of sex steroid receptors, CA125, and gastric mucin. Toki, T., Shiozawa, T., Hosaka, N., Ishii, K., Nikaido, T., Fujii, S. Int. J. Gynecol. Pathol. (1997)
- CA125 expression in epithelioid sarcoma. Kato, H., Hatori, M., Kokubun, S., Watanabe, M., Smith, R.A., Hotta, T., Ogose, A., Morita, T., Murakami, T., Aiba, S. Jpn. J. Clin. Oncol. (2004)
- The prognostic value of CEA, beta HCG, AFP, CA125, CA19-9 and C-erb B-2, beta HCG immunohistochemistry in advanced colorectal cancer. Webb, A., Scott-Mackie, P., Cunningham, D., Norman, A., Andreyev, J., O'Brien, M., Bensted, J. Ann. Oncol. (1995)
- Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. Rump, A., Morikawa, Y., Tanaka, M., Minami, S., Umesaki, N., Takeuchi, M., Miyajima, A. J. Biol. Chem. (2004)
- Usefulness of tumor markers CA 125 and CA 15.3 at diagnosis and during follow-up in non-Hodgkin's lymphoma: study of 200 patients. Batlle, M., Ribera, J.M., Oriol, A., Pastor, C., Mate, J.L., Fernández-Avilés, F., Flores, A., Millá, F., Feliu, E. Leuk. Lymphoma (2005)
- The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure. O'Brien, T.J., Beard, J.B., Underwood, L.J., Shigemasa, K. Tumour Biol. (2002)
- Impact of short-term exposure of commercial eyedrops preserved with benzalkonium chloride on precorneal mucin. Chung, S.H., Lee, S.K., Cristol, S.M., Lee, E.S., Lee, D.W., Seo, K.Y., Kim, E.K. Mol. Vis. (2006)
- Cyst fluid analysis in the differential diagnosis of pancreatic cysts. A comparison of pseudocysts, serous cystadenomas, mucinous cystic neoplasms, and mucinous cystadenocarcinoma. Lewandrowski, K.B., Southern, J.F., Pins, M.R., Compton, C.C., Warshaw, A.L. Ann. Surg. (1993)
- Undifferentiated carcinoma of the vulva mimicking epithelioid sarcoma. Kudo, E., Hirose, T., Fujii, Y., Hasegawa, T., Ino, H., Hizawa, K. Am. J. Surg. Pathol. (1991)
- Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Hori, Y., Spurr-Michaud, S.J., Russo, C.L., Argüeso, P., Gipson, I.K. Invest. Ophthalmol. Vis. Sci. (2005)
- Follicular fluid alpha-fetoprotein, carcinoembryonic antigen, and CA-125 levels in relation to in vitro fertilization and gonadotropin and steroid hormone concentrations. Jimena, P., Castilla, J.A., Ramirez, J.P., Gil, T., Acebal, M., Molina, R., Herruzo, A.J. Fertil. Steril. (1993)
- The CA 125 gene: an extracellular superstructure dominated by repeat sequences. O'Brien, T.J., Beard, J.B., Underwood, L.J., Dennis, R.A., Santin, A.D., York, L. Tumour Biol. (2001)
- Menstrual cycle dependent variability for serum tumor markers CEA, AFP, CA 19-9, CA 125 and CA 15-3 in healthy women. Erbağci, A.B., Yilmaz, N., Kutlar, I. Dis. Markers (1999)
- Comparison of glycoprotein expression between ovarian and colon adenocarcinomas. Multhaupt, H.A., Arenas-Elliott, C.P., Warhol, M.J. Arch. Pathol. Lab. Med. (1999)
- Oxidative damage to DNA of ovarian surface epithelial cells affected by ovulation: carcinogenic implication and chemoprevention. Murdoch, W.J., Martinchick, J.F. Exp. Biol. Med. (Maywood) (2004)
- Effects of irradiation on the expression of surface antigens in human ovarian cancer. Santin, A.D., Hiserodt, J.C., Fruehauf, J., DiSaia, P.J., Pecorelli, S., Granger, G.A. Gynecol. Oncol. (1996)
- A binding domain on mesothelin for CA125/MUC16. Kaneko, O., Gong, L., Zhang, J., Hansen, J.K., Hassan, R., Lee, B., Ho, M. J. Biol. Chem. (2009)
- Fusions of human ovarian carcinoma cells with autologous or allogeneic dendritic cells induce antitumor immunity. Gong, J., Nikrui, N., Chen, D., Koido, S., Wu, Z., Tanaka, Y., Cannistra, S., Avigan, D., Kufe, D. J. Immunol. (2000)
- Clinical value of p53, c-erbB-2, CEA and CA125 regarding relapse, metastasis and death in resectable non-small cell lung cancer. Pollán, M., Varela, G., Torres, A., de la Torre, M., Ludeña, M.D., Ortega, M.D., Pac, J., Freixenet, J., Gómez, G., Sebastián, F., Díez, M., Arrabal, R., Canalís, E., García-Tirado, J., Arnedillo, A., Rivas, J.J., Minguella, J., Gómez, A., García, M., Aragonés, N., Pérez-Gómez, B., López-Abente, G., González-Sarmiento, R., Rojas, J.M. Int. J. Cancer (2003)
- Differential regulation of membrane-associated mucins in the human ocular surface epithelium. Hori, Y., Spurr-Michaud, S., Russo, C.L., Argüeso, P., Gipson, I.K. Invest. Ophthalmol. Vis. Sci. (2004)
- Distinct evolution of the human carcinoma-associated transmembrane mucins, MUC1, MUC4 AND MUC16. Duraisamy, S., Ramasamy, S., Kharbanda, S., Kufe, D. Gene (2006)
- Concentrations of endometrial protein PP 14 and CA-125 in uterine flushings performed in natural and stimulated cycles. Ng, E.H., Laird, S.M., Li, T.C., Yeung, W.S., Ho, P.C. Hum. Reprod. (2004)
- New tumor markers: CA125 and beyond. Bast, R.C., Badgwell, D., Lu, Z., Marquez, R., Rosen, D., Liu, J., Baggerly, K.A., Atkinson, E.N., Skates, S., Zhang, Z., Lokshin, A., Menon, U., Jacobs, I., Lu, K. Int. J. Gynecol. Cancer (2005)
- Isolation and characterization of ovarian cancer antigen CA 125 using a new monoclonal antibody (VK-8): identification as a mucin-type molecule. Lloyd, K.O., Yin, B.W., Kudryashov, V. Int. J. Cancer (1997)
- Expression of WT1, CA 125, and GCDFP-15 as useful markers in the differential diagnosis of primary ovarian carcinomas versus metastatic breast cancer to the ovary. Tornos, C., Soslow, R., Chen, S., Akram, M., Hummer, A.J., Abu-Rustum, N., Norton, L., Tan, L.K. Am. J. Surg. Pathol. (2005)