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Chemical Compound Review

Hafnotrast     hafnium(+4) cation; oxygen(-2) anion

Synonyms: Hafnia (HfO2), AR-1J1453, AR-1J1454, NSC 158931, AC1L4LT0, ...
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Disease relevance of Hafnia


High impact information on Hafnia


Chemical compound and disease context of Hafnia


Biological context of Hafnia


Anatomical context of Hafnia

  • Surface proteins called intimins (Int), which are homologous to the invasin protein (Inv) of Yersinia spp., play a role in inducing brush border damage, termed attachment and effacement, which follows infection by enteropathogenic and enterohemorrhagic Escherichia coli, Citrobacter freundii biotype 4280, and Hafnia alvei [5].
  • In a retrospective review, a group of seven patients were found to have a sputum culture positive for Hafnia alvei [18].
  • Three patients acquired nosocomial bacteria Pseudomonas aeruginosa and Hafnia alvei in the oropharynx, subsequently followed by secondary colonization of the lower airways [19].
  • However, the state reference laboratory detected a toxigenic strain of Hafnia alvei active on Vero cells from two consecutive stool cultures during the acute phase of her illness [20].
  • A number of enteric pathogens, including enteropathogenic (EPEC) and enterohemorrhagic (EHEC) Escherichia coli, Hafnia alvei, a strain of Citrobacter freundii, and rabbit EPEC strain RDEC-1 cause attaching-effacing (AE) lesions in the gut mucosa [21].

Associations of Hafnia with other chemical compounds

  • The application of 1H/13C inversely correlated NMR spectroscopy to the determination of acylation and glycosylation sites in the O-specific polysaccharide from Hafnia alvei 1187 [22].
  • Various porous mineral oxides (silica, titania, zirconia and hafnia) have been characterized in term of fluidization behavior, surface reactivity and chemical resistance to harsh CIP procedures [23].
  • An acidic O-polysaccharide isolated by mild acid hydrolysis from the lipopolysaccharide of Hafnia alvei PCM 1546 is composed of D-Gal, D-Glc, D-GlcA, D-GalNAc and O-acetyl groups in the ratios 1:1:1:2:1 [24].
  • METHODS: We conducted population-based laboratory surveillance in the Calgary Health Region during 2000-2005 to define the incidence, demographic risk factors for acquisition, and anti-microbial susceptibilities of Hafnia alvei isolates [25].
  • Further examination showed that the patient also had abnormal colonization of the duodenum with Hafnia alvei and that this disappeared when the Strongyloides infection was treated with mebendazole [26].

Gene context of Hafnia

  • Judging by the time required for appearance of oxygen bubbles in 3% hydrogen peroxide, the immediate catalase reactors were Yersinia, Serratia, Proteus, Morganella, Providencia, Cedecea, and Hafnia spp [27].
  • (4), hyperproduction of AmpC enzyme in Citrobacter freundii (2), E. aerogenes (3), E. cloacae (3), E. coli (4), Hafnia alvei (1) and Morganella morganii (1), production of plasmid-mediated AmpC beta-lactamase in K. pneumoniae (3) and E. coli (3) or hyperproduction of K1 enzyme in K. oxytoca (6) [28].
  • The strains were initially identified as Hafnia alvei with a commercial identification system and were reported to contain the eae gene of enteropathogenic Escherichia coli [29].
  • The remaining LPS studied, namely, from Salmonella toucra O48 and Hafnia alvei 2, had 4-linked and terminally localized NeuAc residues [30].
  • Acid-base chemical mechanism of aspartase from Hafnia alvei [31].

Analytical, diagnostic and therapeutic context of Hafnia


  1. The genus Hafnia: from soup to nuts. Janda, J.M., Abbott, S.L. Clin. Microbiol. Rev. (2006) [Pubmed]
  2. Reactive arthritis associated with Hafnia alvei enteritis. Newmark, J.J., Hobbs, W.N., Wilson, B.E. Arthritis Rheum. (1994) [Pubmed]
  3. A novel strategy for the isolation of luxI homologues: evidence for the widespread distribution of a LuxR:LuxI superfamily in enteric bacteria. Swift, S., Winson, M.K., Chan, P.F., Bainton, N.J., Birdsall, M., Reeves, P.J., Rees, C.E., Chhabra, S.R., Hill, P.J., Throup, J.P. Mol. Microbiol. (1993) [Pubmed]
  4. Alw26I, Eco31I and Esp3I--type IIs methyltransferases modifying cytosine and adenine in complementary strands of the target DNA. Bitinaite, J., Maneliene, Z., Menkevicius, S., Klimasauskas, S., Butkus, V., Janulaitis, A. Nucleic Acids Res. (1992) [Pubmed]
  5. Characterization of the C-terminal domains of intimin-like proteins of enteropathogenic and enterohemorrhagic Escherichia coli, Citrobacter freundii, and Hafnia alvei. Frankel, G., Candy, D.C., Everest, P., Dougan, G. Infect. Immun. (1994) [Pubmed]
  6. Genetic Environment of Acquired blaACC-1 {beta}-Lactamase Gene in Enterobacteriaceae Isolates. Doloy, A., Verdet, C., Gautier, V., Decr??, D., Ronco, E., Hammami, A., Philippon, A., Arlet, G. Antimicrob. Agents Chemother. (2006) [Pubmed]
  7. Biochemical-genetic characterization and regulation of expression of an ACC-1-like chromosome-borne cephalosporinase from Hafnia alvei. Girlich, D., Naas, T., Bellais, S., Poirel, L., Karim, A., Nordmann, P. Antimicrob. Agents Chemother. (2000) [Pubmed]
  8. Heterogeneity of AmpC cephalosporinases of Hafnia alvei clinical isolates expressing inducible or constitutive ceftazidime resistance phenotypes. Girlich, D., Naas, T., Bellais, S., Poirel, L., Karim, A., Nordmann, P. Antimicrob. Agents Chemother. (2000) [Pubmed]
  9. Comparison of the antibody responses to the 77 Klebsiella capsular types in ankylosing spondylitis and various rheumatic diseases. Sahly, H., Kekow, J., Podschun, R., Schaff, M., Gross, W.L., Ullmann, U. Infect. Immun. (1994) [Pubmed]
  10. Imipenem coadministered with cilastatin compared with moxalactam: integration of serum pharmacokinetics and microbiologic activity following single-dose administration to normal volunteers. Standiford, H.C., Drusano, G.L., Bustamante, C.I., Rivera, G., Forrest, A., Tatem, B., Leslie, J., Moody, M. Antimicrob. Agents Chemother. (1986) [Pubmed]
  11. The effect of biogenic amine production by single bacterial cultures and metabiosis on cold-smoked salmon. Jørgensen, L.V., Huss, H.H., Dalgaard, P. J. Appl. Microbiol. (2000) [Pubmed]
  12. The occurrence of glycine in bacterial lipopolysaccharides. Gamian, A., Mieszala, M., Katzenellenbogen, E., Czarny, A., Zal, T., Romanowska, E. FEMS Immunol. Med. Microbiol. (1996) [Pubmed]
  13. A multidrug resistance regulatory chromosomal locus is widespread among enteric bacteria. Cohen, S.P., Yan, W., Levy, S.B. J. Infect. Dis. (1993) [Pubmed]
  14. Identification of two distinct hybridization groups in the genus Hafnia by 16S rRNA gene sequencing and phenotypic methods. Janda, J.M., Abbott, S.L., Bystrom, S., Probert, W.S. J. Clin. Microbiol. (2005) [Pubmed]
  15. Identification and characterization of integron-mediated antibiotic resistance among Shiga toxin-producing Escherichia coli isolates. Zhao, S., White, D.G., Ge, B., Ayers, S., Friedman, S., English, L., Wagner, D., Gaines, S., Meng, J. Appl. Environ. Microbiol. (2001) [Pubmed]
  16. 3-Deoxy-octulosonic acid-containing trisaccharide fragment of an unusual core type of some Hafnia alvei lipopolysaccharides. Katzenellenbogen, E., Gamian, A., Romanowska, E., Dabrowski, U., Dabrowski, J. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  17. Evolution of the gyrB gene and the molecular phylogeny of Enterobacteriaceae: a model molecule for molecular systematic studies. Dauga, C. Int. J. Syst. Evol. Microbiol. (2002) [Pubmed]
  18. Hafnia alvei. Respiratory tract isolates in a community hospital over a three-year period and a literature review. Klapholz, A., Lessnau, K.D., Huang, B., Talavera, W., Boyle, J.F. Chest (1994) [Pubmed]
  19. Topical antibiotics on tracheostoma prevents exogenous colonization and infection of lower airways in children. Morar, P., Makura, Z., Jones, A., Baines, P., Selby, A., Hughes, J., van Saene, R. Chest (2000) [Pubmed]
  20. Isolation of Toxigenic Hafnia alvei from a Probable Case of Hemolytic Uremic Syndrome. Crandall, C., Abbott, S.L., Zhao, Y.Q., Probert, W., Janda, J.M. Infection (2006) [Pubmed]
  21. Characterization of the eaeA gene from rabbit enteropathogenic Escherichia coli strain RDEC-1 and comparison to other eaeA genes from bacteria that cause attaching-effacing lesions. Agin, T.S., Cantey, J.R., Boedeker, E.C., Wolf, M.K. FEMS Microbiol. Lett. (1996) [Pubmed]
  22. The application of 1H/13C inversely correlated NMR spectroscopy to the determination of acylation and glycosylation sites in the O-specific polysaccharide from Hafnia alvei 1187. Dabrowski, J., Hauck, M., Romanowska, E., Gamian, A. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  23. Characterization of very dense mineral oxide-gel composites for fluidized-bed adsorption of biomolecules. Voute, N., Bataille, D., Girot, P., Boschetti, E. Bioseparation (1999) [Pubmed]
  24. Structure of the O-polysaccharide from the lipopolysaccharide of Hafnia alvei strain PCM 1546. Katzenellenbogen, E., Kocharova, N.A., Zatonsky, G.V., Korzeniowska-Kowal, A., Shashkov, A.S., Knirel, Y.A. Carbohydr. Res. (2003) [Pubmed]
  25. Population-based laboratory surveillance of Hafnia alvei isolates in a large Canadian health region. Laupland, K.B., Church, D.L., Ross, T., Pitout, J.D. Ann. Clin. Microbiol. Antimicrob. (2006) [Pubmed]
  26. A case with severe diarrhoea and Strongyloides stercoralis infection. Moesgaard, F., Steven, K., Engbaek, K. Acta medica Scandinavica. (1981) [Pubmed]
  27. Rapid catalase supplemental test for identification of members of the family Enterobacteriaceae. Chester, B., Moskowitz, L.B. J. Clin. Microbiol. (1987) [Pubmed]
  28. Evaluation of the MicroScan ESBL plus confirmation panel for detection of extended-spectrum beta-lactamases in clinical isolates of oxyimino-cephalosporin-resistant Gram-negative bacteria. Stürenburg, E., Lang, M., Horstkotte, M.A., Laufs, R., Mack, D. J. Antimicrob. Chemother. (2004) [Pubmed]
  29. Prototypal diarrheagenic strains of Hafnia alvei are actually members of the genus Escherichia. Janda, J.M., Abbott, S.L., Albert, M.J. J. Clin. Microbiol. (1999) [Pubmed]
  30. Analysis of 7-substituted sialic acid in some enterobacterial lipopolysaccharides. Gamian, A., Kenne, L. J. Bacteriol. (1993) [Pubmed]
  31. Acid-base chemical mechanism of aspartase from Hafnia alvei. Yoon, M.Y., Thayer-Cook, K.A., Berdis, A.J., Karsten, W.E., Schnackerz, K.D., Cook, P.F. Arch. Biochem. Biophys. (1995) [Pubmed]
  32. Characterization of Hafnia alvei by biochemical tests, random amplified polymorphic DNA PCR, and partial sequencing of 16S rRNA gene. Ridell, J., Siitonen, A., Paulin, L., Lindroos, O., Korkeala, H., Albert, M.J. J. Clin. Microbiol. (1995) [Pubmed]
  33. Hafnia alvei infection after liver transplantation. Barry, J.W., Dominguez, E.A., Boken, D.J., Preheim, L.C. Clin. Infect. Dis. (1997) [Pubmed]
  34. Comparison of anti-pollution modifications of Mapleson A and D anaesthetic systems. Andersen, P.K., Hole, P. British journal of anaesthesia. (1979) [Pubmed]
  35. O-specific polysaccharides of Hafnia alvei lipopolysaccharides isolated from two serologically related strains: ATCC 13337 and 1187. A serological and structural study using chemical methods, gas chromatography/mass spectrometry and NMR spectroscopy at 500 MHz. Gamian, A., Romanowska, E., Opferkuch, H.J., Hauck, M., Dabrowski, J. Eur. J. Biochem. (1989) [Pubmed]
  36. Pulsed-field gel electrophoresis typing of Hafnia alvei isolated from chub-packed and retail ground beef. Gamage, S.D., Luchansky, J.B., Ingham, S.C. Lett. Appl. Microbiol. (1998) [Pubmed]
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