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MeSH Review

Meningeal Neoplasms

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Disease relevance of Meningeal Neoplasms


High impact information on Meningeal Neoplasms

  • This study demonstrates that leucovorin administered i.v. to patients receiving intra-Ommaya MTX does not increase CSF concentrations of "rescue" folate above those of CSF MTX and are unlikely to interfere with MTX action against meningeal tumor [3].
  • To determine whether alterations of hRAD54 are a common event in meningeal tumors, by means of polymerase chain reaction-single-stranded conformation analysis we examined 29 tumor samples characterized by 1p deletions for hRAD54 mutations [4].
  • In this study, 25 meningeal tumors of different histological subtypes, all of which had been previously embolized, were reviewed histologically as well as with immunostaining for the MIBI antigen and proliferating cell nuclear antigen (PCNA) [5].
  • Desmoplakin as one of the desmosomal plaque components has proven to be a reliable marker for diagnosis of meningeal tumors [6].
  • TP-IRS was also detected in supernatants of mouse neuroblastoma (NIE-115) and primary spinal cord cultures but not human astrocytic and meningeal tumors or mouse primary astrocyte cultures [7].

Chemical compound and disease context of Meningeal Neoplasms


Gene context of Meningeal Neoplasms


  1. Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene. Wei, M.X., Tamiya, T., Chase, M., Boviatsis, E.J., Chang, T.K., Kowall, N.W., Hochberg, F.H., Waxman, D.J., Breakefield, X.O., Chiocca, E.A. Hum. Gene Ther. (1994) [Pubmed]
  2. High throughput screening of meningioma biomarkers using a tissue microarray. Lusis, E.A., Chicoine, M.R., Perry, A. J. Neurooncol. (2005) [Pubmed]
  3. Serum and cerebrospinal fluid distribution of 5-methyltetrahydrofolate after intravenous calcium leucovorin and intra-Ommaya methotrexate administration in patients with meningeal carcinomatosis. Mehta, B.M., Glass, J.P., Shapiro, W.R. Cancer Res. (1983) [Pubmed]
  4. Search for mutations of the hRAD54 gene in sporadic meningiomas with deletion at 1p32. Mendiola, M., Bello, M.J., Alonso, J., Leone, P.E., Vaquero, J., Sarasa, J.L., Kusak, M.E., De Campos, J.M., Pestaña, A., Rey, J.A. Mol. Carcinog. (1999) [Pubmed]
  5. Histopathology of post-embolized meningiomas. Ng, H.K., Poon, W.S., Goh, K., Chan, M.S. Am. J. Surg. Pathol. (1996) [Pubmed]
  6. Molecular characterization of desmosomes in meningiomas and arachnoidal tissue. Akat, K., Mennel, H.D., Kremer, P., Gassler, N., Bleck, C.K., Kartenbeck, J. Acta Neuropathol. (2003) [Pubmed]
  7. Immunoreactive thymopoietin in the mouse central nervous system. Brown, R.H., Schweitzer, J.S., Audhya, T., Goldstein, G., Dichter, M.A. Brain Res. (1986) [Pubmed]
  8. Disseminated necrotizing leukoencephalopathy: a complication of treated central nervous system leukemia and lymphoma. Rubinstein, L.J., Herman, M.M., Long, T.F., Wilbur, J.R. Cancer (1975) [Pubmed]
  9. A microbiologic disc assay for 5-methyltetrahydrofolate in the presence of methotrexate. Mehta, B.M., Hutchison, D.J. Cancer treatment reports. (1977) [Pubmed]
  10. Primary leptomeningeal sarcomatosis. Clinicopathological report of six cases. Budka, H., Pilz, P., Guseo, A. J. Neurol. (1975) [Pubmed]
  11. Expression and structure of interleukin 4 receptors in primary meningeal tumors. Puri, S., Joshi, B.H., Sarkar, C., Mahapatra, A.K., Hussain, E., Sinha, S. Cancer (2005) [Pubmed]
  12. Immunocytochemistry of intracranial meningiomas. Hitchcock, E., Morris, C.S. J. Neurooncol. (1987) [Pubmed]
  13. Comparative effects of citrovorum factor and carboxypeptidase G1 on cerebrospinal fluid-methotrexate pharmacokinetics. Abelson, H.T., Ensminger, W., Rosowsky, A., Uren, J. Cancer treatment reports. (1978) [Pubmed]
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