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MeSH Review:

Lupus Erythematosus, Discoid

Lee, L.A. et al., Lagogianni, I. et al., Norris, D.A., Michel, M. et al., Sundqvist, K.G. et al., et al.

Furukawa, Itoh, Wakita, Yagi, Tokura, Norris, Takigawa, Powell, Albert, Bhogal, Black, Michel, Johanet, Meyer, Francès, Wittke, Michel, Arfi, Tournier-Lasserve, Piette,

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Disease relevance of Lupus Erythematosus, Discoid

In the present study, we describe the main clinical and immunologic features of 125 lupus multiplex families including at least 2 cases of SLE and/or discoid lupus erythematosus (DLE), recruited through a French national survey starting in July 1997 [1].
This review discusses the mechanisms involved in different photosensitive lupus syndromes: acute cutaneous lupus erythematosus, chronic cutaneous (discoid) lupus erythematosus, subacute cutaneous lupus erythematosus, and neonatal lupus erythematosus [2].
Hypertrophic discoid lupus erythematosus (HDLE) may resemble cutaneous squamous cell carcinoma (SCC) histologically [3].
The expression of lymphocyte activation markers (IL2 receptors, transferrin receptors and HLA-DR) was examined in cutaneous lymphoid infiltrates of 12 patients with lichen ruber planus (LP) and 10 individuals with discoid lupus erythematosus (DLE) [4].

High impact information on Lupus Erythematosus, Discoid

Cross-reactive anti-DNA antibody idiotypes have been identified on tissue-bound immunoglobulins from skin biopsies of patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) [5].
Sulfasalazine is an effective agent for chronic discoid lupus erythematosus (CDLE) but the response to treatment is considerably variable between patients and is also unpredictable [6].
OBJECTIVES: To characterize the amyloid deposition observed incidentally within lesional biopsies from three patients with discoid lupus erythematosus (DLE), and retrospectively to study the phenomenon within DLE skin samples [7].
BACKGROUND AND DESIGN: Seventeen patients with subacute cutaneous lupus erythematosus (SCLE) were compared with 15 patients with discoid lupus erythematosus (DLE) to evaluate the relationship of 60- and 52-kd Ro/SSA autoantibodies to the clinical diagnosis and to evaluate assays for anti-Ro/SSA [8].
We studied polyclonal B-cell activation in twenty-six patients with discoid lupus erythematosus (DLE) [9].

Chemical compound and disease context of Lupus Erythematosus, Discoid

The therapeutic effect of thalidomide in chronic discoid lupus erythematosus (CDLE) was studied in sixty patients who were followed up for 2 years [10].
Levels of IFN were measured in serum samples from 22 patients with systemic lupus erythematosus (SLE) and 12 patients with discoid lupus erythematosus (DLE) before and 24 h after dipyridamole administration [11].
We treated seven patients with discoid lupus erythematosus (DLE) with Vitamin E in an oral dose of 400 mg three times per day for 12 weeks [12].
OBJECTIVES: The aim of the present study was to evaluate the dyslipidemic profile of patients with Cutaneous Discoid Lupus Erythematosus (DLE) with particular emphasis on the levels of High Density Lipoprotein (HDL) Cholesterol and its subfractions, HDL2 and HDL3 [13].
Discoid lupus erythematosus (DLE)-like lesion induced by uracil-tegafur (UFT) [14].

Biological context of Lupus Erythematosus, Discoid

ADCC experiments were also performed using keratinocytes cultured from patients with SLE, SCLE, discoid lupus erythematosus (DLE), and normal controls [15].

Gene context of Lupus Erythematosus, Discoid

HLA-A, B, C and Bf typing was performed in 55 cases of Discoid Lupus Erythematosus (DLE) [16].
The distribution of HL-A antigens and lymphocytotoxic antibodies has been studied in the sera of patients suffering from discoid lupus erythematosus (DLE) [17].

Analytical, diagnostic and therapeutic context of Lupus Erythematosus, Discoid

Two HIV-infected female patients with SLE and discoid lupus erythematosus (DLE) diagnosed a few months after the highly active antiretroviral therapy initiation, are described [18].

References

Familial lupus erythematosus. Clinical and immunologic features of 125 multiplex families. Michel, M., Johanet, C., Meyer, O., Francès, C., Wittke, F., Michel, C., Arfi, S., Tournier-Lasserve, E., Piette, J.C. Medicine (Baltimore) (2001) [Pubmed]
Pathomechanisms of photosensitive lupus erythematosus. Norris, D.A. J. Invest. Dermatol. (1993) [Pubmed]
Hypertrophic discoid lupus erythematosus resembling squamous cell carcinoma. Perniciaro, C., Randle, H.W., Perry, H.O. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (1995) [Pubmed]
Expression of lymphocyte activation markers in benign cutaneous T cell infiltrates. Discoid lupus erythematosus versus lichen ruber planus. Sundqvist, K.G., Wanger, L. Acta Derm. Venereol. (1989) [Pubmed]
Detection of cross reactive anti-DNA antibody idiotypes on tissue-bound immunoglobulins from skin biopsies of lupus patients. Isenberg, D., Dudeney, C., Wojnaruska, F., Bhogal, B.S., Rauch, J., Schattner, A., Naparstek, Y., Duggan, D. J. Immunol. (1985) [Pubmed]
NAT2 genotyping and efficacy of sulfasalazine in patients with chronic discoid lupus erythematosus. Sabbagh, N., Delaporte, E., Marez, D., Lo-Guidice, J.M., Piette, F., Broly, F. Pharmacogenetics (1997) [Pubmed]
Discoid lupus erythematosus with secondary amyloidosis. Powell, A.M., Albert, S., Bhogal, B., Black, M.M. Br. J. Dermatol. (2005) [Pubmed]
The autoantibody response to Ro/SSA in cutaneous lupus erythematosus. Lee, L.A., Roberts, C.M., Frank, M.B., McCubbin, V.R., Reichlin, M. Archives of dermatology. (1994) [Pubmed]
Polyclonal B-cell activation and increased lymphocyte helper-suppressor ratios in discoid lupus erythematosus. Wangel, A.G., Johansson, E., Ranki, A. Br. J. Dermatol. (1984) [Pubmed]
Thalidomide in the treatment of sixty cases of chronic discoid lupus erythematosus. Knop, J., Bonsmann, G., Happle, R., Ludolph, A., Matz, D.R., Mifsud, E.J., Macher, E. Br. J. Dermatol. (1983) [Pubmed]
Interferon response to dipyridamole in lupus erythematosus patients. Konstantinov, K., Galabov, A., Mastikova, M. Br. J. Dermatol. (1989) [Pubmed]
Vitamin E and discoid lupus erythematosus. Yell, J.A., Burge, S., Wojnarowska, F. Lupus (1992) [Pubmed]
Evidence of reduced plasma HDL subfractions in patients with cutaneous discoid lupus erythematosus. Lagogianni, I., Papapanagiotou, A., Piperi, C., Kalofoutis, C., Troupis, G., Zachari, A., Kalofoutis, A. Clin. Biochem. (2005) [Pubmed]
Discoid lupus erythematosus (DLE)-like lesion induced by uracil-tegafur (UFT). Yoshimasu, T., Hiroi, A., Uede, K., Furukawa, F. European journal of dermatology : EJD. (2001) [Pubmed]
Keratinocytes from patients with lupus erythematosus show enhanced cytotoxicity to ultraviolet radiation and to antibody-mediated cytotoxicity. Furukawa, F., Itoh, T., Wakita, H., Yagi, H., Tokura, Y., Norris, D.A., Takigawa, M. Clin. Exp. Immunol. (1999) [Pubmed]
HLA antigens in discoid lupus erythematosus. Tongio, M.M., Fersing, J., Hauptmann, G., Mayer, S., Grange, D., Samsoen, M., Groshans, E. Acta Derm. Venereol. (1982) [Pubmed]
Examination of HL-A antigens and lymphocytotoxic antibodies in discoid lupus erythematosus. Stenszky, V., Nagy, E., Szerze, P. Acta Derm. Venereol. (1975) [Pubmed]
Systemic and discoid lupus erythematosus in HIV-infected patients treated with highly active antiretroviral therapy. Calza, L., Manfredi, R., Colangeli, V., D'Antuono, A., Passarini, B., Chiodo, F. International journal of STD & AIDS. (2003) [Pubmed]

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