Disease relevance of Minor Histocompatibility Loci

• P815 mastocytoma (DBA/2; H-2d) cells are syngeneic with BALB/c hosts at the major histocompatibility locus, but differ at multiple minor histocompatibility loci [1].
• Autoimmune disease in inbred mice is probably determined by co-dominant genes associated with both the major and minor histocompatibility loci [2].
• A gene linked to a minor histocompatibility locus (H-3) on the second chromosome also influences susceptibility to glucocorticoid- and phenytoin-induced cleft palate [3].

High impact information on Minor Histocompatibility Loci

• Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex [4].
• A new minor histocompatibility locus linked to H-3 [5].
• 1. F1 complementation of skin graft rejection and generation of CTL indicated that A.BY and BALB.B do not share H-3a with B10 as previously reported but possess the c allele of their congenic partners A and BALB/c. Thus, B10.LP-H-3b and B10 differ from one another by at least 2 minor histocompatibility loci [5].
• Finally, a decrease in both immune function and CSF production capacity was observed in the acute GVH following allogeneic (minor histocompatibility loci) bone marrow transplantation into irradiated hosts [6].
• Analysis of congenic resistant strains indicates that Tam-1 is closely linked to the minor histocompatibility locus, H-4 [7].

Biological context of Minor Histocompatibility Loci

• Human minor histocompatibility antigens remain ill-defined, but minor histocompatibility loci have been mapped on nearly every mouse chromosome [8].
• Biochemical and immunogenetic analysis of an immunodominant peptide (B6dom1) encoded by the classical H7 minor histocompatibility locus [9].
• P815 mastocytoma (DBA/2; H-2d) cells are syngeneic with BALB/c hosts at the major histocompatibility complex but differ at numerous minor histocompatibility loci [10].
• The purpose of this study was to further elucidate the mechanism and kinetics of epithelial injury in acute GVHD produced in mouse strains (B10.BR/CBA) receiving bone marrow transplants across minor histocompatibility loci [11].

Anatomical context of Minor Histocompatibility Loci

• Overall, depletion of T cells from donor BM allografts incompatible at minor histocompatibility loci, did not seem to significantly alter the rate of immunohematopoietic reconstitution in the lethally irradiated BM recipients [12].

Gene context of Minor Histocompatibility Loci

• Complexity at the mouse minor histocompatibility locus H-4 [13].
• Although the locus coding for this antigen appears to be closely linked to the minor histocompatibility locus H-30 and to the locus coding for Ly 6.2, a chromosome assignment has not yet been made for my of these loci [14].
• Their apparent association with the Hh and H-18 loci suggests that they may be genes coding for minor histocompatibility loci [15].
• The functional basis of minor histocompatibility loci [16].
• It is generally accepted that minor histocompatibility loci in the murine model have a degree of polymorphism similar to that of H-2K or H-2D [17].

Analytical, diagnostic and therapeutic context of Minor Histocompatibility Loci

• Before transplantation into irradiated mice differing at major and minor histocompatibility loci, rmu GM-CSF was preincubated with T cell-depleted donor marrow [18].
• Permanent reversal of experimental diabetes in rats by allogeneic fetal pancreases across minor histocompatibility loci: effects and characteristics of immunosuppression induced by alloantigen, PCH, and ALS treatment [19].

References