Disease relevance of H18

• The putative H18 pol gene (900 residues) was homologous to the Rous sarcoma virus pol gene almost throughout the entire region [1].
• The putative H18 gag gene (809 amino acids) had a sequence homologous to the N-terminal half of the mouse mammary tumor virus gag gene and locally to the Rous sarcoma virus gag gene [1].

High impact information on H18

• The size of the LTRs was 350 base-pairs (bp) and 376 bp in two clones, H10 and H18, respectively [2].
• We determined the complete nucleotide sequence of the intracisternal A-particle gene, IAP-H18, cloned from the normal Syrian hamster liver DNA [1].
• IAP-H18 was 7,951 base pairs in length with two identical long terminal repeats of 376 base pairs at both ends [1].
• In the present study, the pharmacological effects of this Dexa-mouse antihuman E-selectin antibody (H18/7) (Ab(hEsel)) conjugate were investigated and compared to the effects obtained by free Dexa in human umbilical vein endothelial cells [3].
• The vector was then used to exogenously control the expression of bcl-XL in H18 hybridoma cells [4].

Biological context of H18

• B6.C-H18 (B6 mice congenic for the BALB/c H18 gene of chromosome 4) were much more susceptible than B6 mice, but were less susceptible than BALB/c mice, supporting the data obtained with the recombinant inbred strain mice, but suggesting that other genes may also influence resistance to infection with MP [5].
• Their apparent association with the Hh and H-18 loci suggests that they may be genes coding for minor histocompatibility loci [6].
• The binding of three neutralizing anti-E-selectin mAb's (E-1E4, H18/7 and CL2), whose epitopes were found to overlap with the E-selectin binding site for carbohydrate ligands, was not affected by the amino acid substitutions at these five positions [7].

Other interactions of H18

• The cross-over value of 37+/-4% places this gene in the neighbourhood of the minor histocompatibility locus H-18, provided it is on the same side of the b locus [6].
• Of 23 EPEC strains, 7 (30%) belonging to serotypes O18ac: H7 (Hly+), O20: H26 (lethal), O26: H- (Hly+), O44: H18 (Hly+), O55: H- (CNF2+, necrotic and lethal), O119: H27 (VT+ and Hly+) and O142: H6 (lethal) produced toxic factors [8].

References