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Nagase, M. et al.

Nagase, Ando, Nagase, Kaname, Sawamura, Fujita,

Redox-sensitive regulation of lox-1 gene expression in vascular endothelium.

Oxidative stress has been implicated in atherosclerosis and its underlying conditions. LOX-1 is a novel endothelial receptor for oxidized low-density lipoprotein which might mediate endothelial dysfunction and subsequent atherogenesis. In the present study, we examined LOX-1 gene regulation by oxidative stress. First, superoxide anions generated by hypoxanthine and xanthine oxidase as well as hydrogen peroxide increased LOX-1 mRNA expression in cultured aortic endothelial cells. Homocysteine, an atherogenic substance believed to exert its effects through oxidative stress, enhanced endothelial LOX-1 gene expression, which was suppressed by N-acetylcysteine. Second, rats receiving angiotensin II for 10 days manifested hypertension and LOX-1 upregulation in aortic endothelium via AT1 receptor. Tempo, a superoxide dismutase mimetic, alleviated LOX-1 augmentation induced by angiotensin II. These results indicated redox-sensitive upregulation of LOX-1 mRNA in both in vitro and in vivo systems, suggesting its potential role in atherosclerosis.[1]

References

Redox-sensitive regulation of lox-1 gene expression in vascular endothelium. Nagase, M., Ando, K., Nagase, T., Kaname, S., Sawamura, T., Fujita, T. Biochem. Biophys. Res. Commun. (2001) [Pubmed]

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