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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Management of severe head injury: institutional variations in care and effect on outcome.

OBJECTIVE: The purpose of this study was three-fold: a) to examine variations in care of patients with severe head injury in academic trauma centers across the United States; b) to determine the proportion of patients who received care according to the Brain Trauma Foundation guidelines; and c) to correlate the outcome from severe traumatic brain injury with the care received. DESIGN: Retrospective data collection for consecutive patients with closed head injury and long bone fracture admitted over an 8-month period. SETTING: Thirty-four academic trauma centers in the United States PATIENTS: All patients admitted with a presenting Glasgow Coma Scale score < or = 8. MEASUREMENTS AND MAIN RESULTS: Variations in care were assessed, including prehospital intubation, intracranial pressure monitoring, use of osmotic agents, hyperventilation, and computed tomography scan utilization. Aggressive centers were defined as those placing intracranial pressure monitors in >50% of patients meeting the Brain Trauma Foundation criteria for intracranial pressure monitoring. The primary outcome variables were mortality, functional status at discharge, and length of stay. Kaplan-Meier survival analysis was performed for aggressive vs. nonaggressive centers. A Cox proportional hazard model was used to evaluate the association between type of center and mortality rate. Length of stay was evaluated by using linear regression. RESULTS: There was considerable variation in the rates of prehospital intubation, intracranial pressure monitoring, intracranial pressure-directed therapy, and head computed tomography scan utilization across centers. Management at an aggressive center was associated with a significant reduction in the risk of mortality (hazard ratio, 0.43; 95% confidence interval, 0.27-0.66). There was no statistically significant difference in functional status at the time of discharge for survivors. Adjusted length of stay for survivors at aggressive centers was shorter, compared with the length of stay at nonaggressive centers: -6 days (95% confidence interval, -14 to 2 days). CONCLUSION: Considerable national variation in the care of severely head-injured patients persists. An "aggressive" management strategy is associated with decreased mortality rate for patients with severe head injury, with no significant difference in functional status at discharge among survivors.[1]


  1. Management of severe head injury: institutional variations in care and effect on outcome. Bulger, E.M., Nathens, A.B., Rivara, F.P., Moore, M., MacKenzie, E.J., Jurkovich, G.J. Crit. Care Med. (2002) [Pubmed]
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