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MeSH Review

Fractures, Bone

 
 
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Disease relevance of Fractures, Bone

 

High impact information on Fractures, Bone

 

Chemical compound and disease context of Fractures, Bone

 

Biological context of Fractures, Bone

  • Homozygous oim mice experience multiple bone fractures under standard laboratory animal housing conditions and are representative of moderate to severe forms of OI [16].
  • Platelet-enriched plasma (PRP) is used in therapy as a source of growth factors in bone fracture and wound healing; however, few data exist on its role in the different aspects of the healing process [17].
  • ApoE genotype appears to be an important genetic risk factor for bone fracture, possibly due to its previously reported influence on vitamin K concentrations in blood [18].
  • OBJECTIVES: Ageing in men is associated with a gradual decline in serum testosterone levels and a concomitant loss of muscle mass, accumulation of central adiposity, impaired mobility and increased risk of bone fractures [19].
  • In conclusion, the data indicate that individual variations in cell number, cell morphology and in the osteogenic potential of progenitor cells of the patient may be relevant for a successful treatment of bone fractures in the elderly by cell-based therapy approaches [20].
 

Anatomical context of Fractures, Bone

 

Gene context of Fractures, Bone

  • The present findings suggest that IGF-I and IGFBP-3 are important to maintaining bone mass quantitatively as well as qualitatively, and that the determination of serum IGF-I and IGFBP-3 levels could be clinically useful to predict the severity of osteoporosis, particularly the risk of bone fracture associated with osteoporosis [26].
  • Evidence for cell-specific changes with age in expression of oestrogen receptor (ER) alpha and beta in bone fractures from men and women [27].
  • The median RANKL/OPG mRNA ratio was significantly greater in hip fracture bone than in bone from controls (4.8 [3.8-7.6] > 3.2 [2.1-4.0], P < 0.05) [28].
  • Gremlin transgenics exhibited bone fractures and reduced bone mineral density by 20-30%, compared with controls [29].
  • In the group of patients with bone fractures alone only a transient increase of bFGF immunoreactivity (threefold above the normal values) was observed in the second week after injury [30].
 

Analytical, diagnostic and therapeutic context of Fractures, Bone

References

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  18. Bone fracture history and prospective bone fracture risk of hemodialysis patients are related to apolipoprotein E genotype. Kohlmeier, M., Saupe, J., Schaefer, K., Asmus, G. Calcif. Tissue Int. (1998) [Pubmed]
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  20. Properties of human trabecular bone cells from elderly women: implications for cell-based bone engraftment. Mayer, H. Cells Tissues Organs (Print) (2004) [Pubmed]
  21. Synthesis of novel 2-benzothiopyran and 3-benzothiepin derivatives and their stimulatory effect on bone formation. Oda, T., Notoya, K., Gotoh, M., Taketomi, S., Fujisawa, Y., Makino, H., Sohda, T. J. Med. Chem. (1999) [Pubmed]
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  28. Increased expression of IL-6 and RANK mRNA in human trabecular bone from fragility fracture of the femoral neck. Tsangari, H., Findlay, D.M., Kuliwaba, J.S., Atkins, G.J., Fazzalari, N.L. Bone (2004) [Pubmed]
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