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MeSH Review

Fractures, Bone

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Disease relevance of Fractures, Bone


High impact information on Fractures, Bone


Chemical compound and disease context of Fractures, Bone


Biological context of Fractures, Bone

  • Homozygous oim mice experience multiple bone fractures under standard laboratory animal housing conditions and are representative of moderate to severe forms of OI [16].
  • Platelet-enriched plasma (PRP) is used in therapy as a source of growth factors in bone fracture and wound healing; however, few data exist on its role in the different aspects of the healing process [17].
  • ApoE genotype appears to be an important genetic risk factor for bone fracture, possibly due to its previously reported influence on vitamin K concentrations in blood [18].
  • OBJECTIVES: Ageing in men is associated with a gradual decline in serum testosterone levels and a concomitant loss of muscle mass, accumulation of central adiposity, impaired mobility and increased risk of bone fractures [19].
  • In conclusion, the data indicate that individual variations in cell number, cell morphology and in the osteogenic potential of progenitor cells of the patient may be relevant for a successful treatment of bone fractures in the elderly by cell-based therapy approaches [20].

Anatomical context of Fractures, Bone


Gene context of Fractures, Bone

  • The present findings suggest that IGF-I and IGFBP-3 are important to maintaining bone mass quantitatively as well as qualitatively, and that the determination of serum IGF-I and IGFBP-3 levels could be clinically useful to predict the severity of osteoporosis, particularly the risk of bone fracture associated with osteoporosis [26].
  • Evidence for cell-specific changes with age in expression of oestrogen receptor (ER) alpha and beta in bone fractures from men and women [27].
  • The median RANKL/OPG mRNA ratio was significantly greater in hip fracture bone than in bone from controls (4.8 [3.8-7.6] > 3.2 [2.1-4.0], P < 0.05) [28].
  • Gremlin transgenics exhibited bone fractures and reduced bone mineral density by 20-30%, compared with controls [29].
  • In the group of patients with bone fractures alone only a transient increase of bFGF immunoreactivity (threefold above the normal values) was observed in the second week after injury [30].

Analytical, diagnostic and therapeutic context of Fractures, Bone


  1. Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect. Bergo, M.O., Gavino, B., Ross, J., Schmidt, W.K., Hong, C., Kendall, L.V., Mohr, A., Meta, M., Genant, H., Jiang, Y., Wisner, E.R., Van Bruggen, N., Carano, R.A., Michaelis, S., Griffey, S.M., Young, S.G. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Osteoclast-stimulating factor interacts with the spinal muscular atrophy gene product to stimulate osteoclast formation. Kurihara, N., Menaa, C., Maeda, H., Haile, D.J., Reddy, S.V. J. Biol. Chem. (2001) [Pubmed]
  3. Effect of tamoxifen on lumbar spine bone mineral density in postmenopausal women after 5 years. Love, R.R., Barden, H.S., Mazess, R.B., Epstein, S., Chappell, R.J. Arch. Intern. Med. (1994) [Pubmed]
  4. Letrozole : in postmenopausal hormone-responsive early-stage breast cancer. Scott, L.J., Keam, S.J. Drugs (2006) [Pubmed]
  5. Procoagulant activity in patients with isolated severe head trauma. Scherer, R.U., Spangenberg, P. Crit. Care Med. (1998) [Pubmed]
  6. Epilepsy, broken bones, and fatty stools. Drenth, J.P., Pieters, G.F., Hermus, A.R. Lancet (2000) [Pubmed]
  7. Heparin therapy and bone fractures. Murphy, M.S., John, P.R., Mayer, A.D., Buckels, J.A., Kelly, D.A. Lancet (1992) [Pubmed]
  8. Diminished callus size and cartilage synthesis in alpha 1 beta 1 integrin-deficient mice during bone fracture healing. Ekholm, E., Hankenson, K.D., Uusitalo, H., Hiltunen, A., Gardner, H., Heino, J., Penttinen, R. Am. J. Pathol. (2002) [Pubmed]
  9. Transforming growth factor-beta regulates collagen gel contraction by increasing alpha 2 beta 1 integrin expression in osteogenic cells. Riikonen, T., Koivisto, L., Vihinen, P., Heino, J. J. Biol. Chem. (1995) [Pubmed]
  10. Evaluation of factors associated with glucocorticoid-induced osteopenia in patients with rheumatic diseases. Dykman, T.R., Gluck, O.S., Murphy, W.A., Hahn, T.J., Hahn, B.H. Arthritis Rheum. (1985) [Pubmed]
  11. Effect of long-term exposure to fluoride in drinking water on risks of bone fractures. Li, Y., Liang, C., Slemenda, C.W., Ji, R., Sun, S., Cao, J., Emsley, C.L., Ma, F., Wu, Y., Ying, P., Zhang, Y., Gao, S., Zhang, W., Katz, B.P., Niu, S., Cao, S., Johnston, C.C. J. Bone Miner. Res. (2001) [Pubmed]
  12. Characterization of aromatase and 17 beta-hydroxysteroid dehydrogenase expression in rat osteoblastic cells. Eyre, L.J., Bland, R., Bujalska, I.J., Sheppard, M.C., Stewart, P.M., Hewison, M. J. Bone Miner. Res. (1998) [Pubmed]
  13. Clinical review 145: Pleiotropic effects of statins: lipid reduction and beyond. McFarlane, S.I., Muniyappa, R., Francisco, R., Sowers, J.R. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  14. Effects of a hydrogenated form of vitamin K on bone formation and resorption. Booth, S.L., Lichtenstein, A.H., O'Brien-Morse, M., McKeown, N.M., Wood, R.J., Saltzman, E., Gundberg, C.M. Am. J. Clin. Nutr. (2001) [Pubmed]
  15. Pamidronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease. Fitton, A., McTavish, D. Drugs (1991) [Pubmed]
  16. Heterozygous oim mice exhibit a mild form of osteogenesis imperfecta. Saban, J., Zussman, M.A., Havey, R., Patwardhan, A.G., Schneider, G.B., King, D. Bone (1996) [Pubmed]
  17. Effect of platelet-rich plasma on migration and proliferation of SaOS-2 osteoblasts: role of platelet-derived growth factor and transforming growth factor-beta. Celotti, F., Colciago, A., Negri-Cesi, P., Pravettoni, A., Zaninetti, R., Sacchi, M.C. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. (2006) [Pubmed]
  18. Bone fracture history and prospective bone fracture risk of hemodialysis patients are related to apolipoprotein E genotype. Kohlmeier, M., Saupe, J., Schaefer, K., Asmus, G. Calcif. Tissue Int. (1998) [Pubmed]
  19. Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Isidori, A.M., Giannetta, E., Greco, E.A., Gianfrilli, D., Bonifacio, V., Isidori, A., Lenzi, A., Fabbri, A. Clin. Endocrinol. (Oxf) (2005) [Pubmed]
  20. Properties of human trabecular bone cells from elderly women: implications for cell-based bone engraftment. Mayer, H. Cells Tissues Organs (Print) (2004) [Pubmed]
  21. Synthesis of novel 2-benzothiopyran and 3-benzothiepin derivatives and their stimulatory effect on bone formation. Oda, T., Notoya, K., Gotoh, M., Taketomi, S., Fujisawa, Y., Makino, H., Sohda, T. J. Med. Chem. (1999) [Pubmed]
  22. Nociceptive atrophy of the rat soleus muscle induced by bone fracture: a morphometric study. Zacharová, G., Knotková-Urbancová, H., Hník, P., Soukup, T. J. Appl. Physiol. (1997) [Pubmed]
  23. Phenytoin inhibition: failure to inhibit periosteal responses to lathyrogen. Fallon, M.D., Yeager, V.L., Taylor, J.L. Arch. Pathol. Lab. Med. (1977) [Pubmed]
  24. Strategies of hemopoietic stress adaptation within the medullary cavity. Giuliani, D.C., Hall, J.C., Morse, B.S. Anat. Rec. (1986) [Pubmed]
  25. Effect of bed rest on the adenine nucleotides concentration in human blood platelets. Buczyński, A., Kedziora, J., Wachowicz, B., Zołyński, K. J. Physiol. Pharmacol. (1991) [Pubmed]
  26. Serum levels of insulin-like growth factor (IGF) I, IGF-binding protein (IGFBP)-2, and IGFBP-3 in osteoporotic patients with and without spinal fractures. Sugimoto, T., Nishiyama, K., Kuribayashi, F., Chihara, K. J. Bone Miner. Res. (1997) [Pubmed]
  27. Evidence for cell-specific changes with age in expression of oestrogen receptor (ER) alpha and beta in bone fractures from men and women. Batra, G.S., Hainey, L., Freemont, A.J., Andrew, G., Saunders, P.T., Hoyland, J.A., Braidman, I.P. J. Pathol. (2003) [Pubmed]
  28. Increased expression of IL-6 and RANK mRNA in human trabecular bone from fragility fracture of the femoral neck. Tsangari, H., Findlay, D.M., Kuliwaba, J.S., Atkins, G.J., Fazzalari, N.L. Bone (2004) [Pubmed]
  29. Skeletal overexpression of gremlin impairs bone formation and causes osteopenia. Gazzerro, E., Pereira, R.C., Jorgetti, V., Olson, S., Economides, A.N., Canalis, E. Endocrinology (2005) [Pubmed]
  30. Basic fibroblast growth factor (BFGF) immunoreactivity as a possible link between head injury and impaired bone fracture healing. Wildburger, R., Zarkovic, N., Egger, G., Petek, W., Zarkovic, K., Hofer, H.P. Bone and mineral. (1994) [Pubmed]
  31. Polylactide implants and bacterial contamination: an animal study. Mainil-Varlet, P., Hauke, C., Maquet, V., Printzen, G., Arens, S., Schaffner, T., Jér me, R., Perren, S., Schlegel, U. J. Biomed. Mater. Res. (2001) [Pubmed]
  32. Preparation and characterization of biodegradable chitosan/hydroxyapatite nanocomposite rods via in situ hybridization: a potential material as internal fixation of bone fracture. Hu, Q., Li, B., Wang, M., Shen, J. Biomaterials (2004) [Pubmed]
  33. Thiazide diuretics and bone mineral content in postmenopausal women. Adland-Davenport, P., McKenzie, M.W., Notelovitz, M., McKenzie, L.C., Pendergast, J.F. Am. J. Obstet. Gynecol. (1985) [Pubmed]
  34. Bone density, mineral content, and cortical index in patients with thalassemia major and the correlation to their bone fractures, blood transfusions, and treatment with desferrioxamine. Orvieto, R., Leichter, I., Rachmilewitz, E.A., Margulies, J.Y. Calcif. Tissue Int. (1992) [Pubmed]
  35. Androgens, cardiovascular disease and osteoporosis. Isidori, A.M., Giannetta, E., Pozza, C., Bonifacio, V., Isidori, A. J. Endocrinol. Invest. (2005) [Pubmed]
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