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Chemical Compound Review

gamma-Thio-ATP     [[[(3R,4R)-5-(6-aminopurin-9- yl)-3,4...

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Disease relevance of gamma-Thio-ATP


High impact information on gamma-Thio-ATP

  • In addition, HsRad51 bound gamma-thio-ATP and formed stable presynaptic complexes that promoted renaturation as rapidly as RecA, but the recombinant human protein catalyzed neither strand exchange nor homologous pairing of a single strand with duplex DNA in the presence of the ATP analog [3].
  • Our results suggest that the binding of ATP to alpha-crystallin and not its hydrolysis is required for all these effects, as replacement of ATP by its nonhydrolyzable analogue adenosine-5'-O-(3-thiotriphosphate), tetralithium salt, reproduced all the results faithfully [4].
  • This is the reason why Mg2+ inhibits Ca2+ binding, and this inhibition is removed in the presence of adenosine-5'-O-(3-thiotriphosphate) which drives Mg2+ into the catalytic site [5].
  • RecA protein-mediated DNA strand exchange is affected minimally by changes in reaction conditions (dilution, pH shift, or addition of small amounts of adenosine-5'-O-(3-thiotriphosphate) that have large and demonstrable effects on recA protein association, dissociation, or both [6].
  • 2. Shortening was also dependent on [ATP] but could be increased at low [ATP] by pretreatment with adenosine-5'-O-(3-thiotriphosphate) (ATP gamma S), which suggests that myosin phosphorylation was more sensitive to low substrate concentrations than was cross-bridge cycling [7].

Biological context of gamma-Thio-ATP


Anatomical context of gamma-Thio-ATP


Associations of gamma-Thio-ATP with other chemical compounds


Gene context of gamma-Thio-ATP

  • UTP and ATP were very effective analogues to activate p38-MAPK, whereas ADP and gamma-thio-ATP had only moderate activating effects [16].
  • UTP, ATP and gamma-thio-ATP are the only compounds capable of activating PKB [9].

Analytical, diagnostic and therapeutic context of gamma-Thio-ATP


  1. Adenosine-5'-O-(3-thiotriphosphate) as an affinity probe for studying leader RNA's transcribed by vesicular stomatitis virus. Carroll, A.R., Wagner, R.R. J. Biol. Chem. (1979) [Pubmed]
  2. Fluorescence study of the RecA-dependent proteolysis of LexA, the repressor of the SOS system in Escherichia coli. Takahashi, M., Daune, M., Schnarr, M. FEBS Lett. (1986) [Pubmed]
  3. Activities of human recombination protein Rad51. Gupta, R.C., Bazemore, L.R., Golub, E.I., Radding, C.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Role of ATP on the interaction of alpha-crystallin with its substrates and its implications for the molecular chaperone function. Biswas, A., Das, K.P. J. Biol. Chem. (2004) [Pubmed]
  5. Ca2+ binding to sarcoplasmic reticulum ATPase revisited. II. Equilibrium and kinetic evidence for a two-route mechanism. Forge, V., Mintz, E., Guillain, F. J. Biol. Chem. (1993) [Pubmed]
  6. Assembly and disassembly of RecA protein filaments occur at opposite filament ends. Relationship to DNA strand exchange. Lindsley, J.E., Cox, M.M. J. Biol. Chem. (1990) [Pubmed]
  7. Physiological and structural properties of saponin-skinned single smooth muscle cells. Kargacin, G.J., Fay, F.S. J. Gen. Physiol. (1987) [Pubmed]
  8. Initiation of methyl-directed mismatch repair. Au, K.G., Welsh, K., Modrich, P. J. Biol. Chem. (1992) [Pubmed]
  9. Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y(2) purinoceptor in renal mesangial cells. Huwiler, A., Rölz, W., Dorsch, S., Ren, S., Pfeilschifter, J. Br. J. Pharmacol. (2002) [Pubmed]
  10. Purinoceptor-coupled Cl- channels in mouse heart: a novel, alternative pathway for CFTR regulation. Duan, D., Ye, L., Britton, F., Miller, L.J., Yamazaki, J., Horowitz, B., Hume, J.R. J. Physiol. (Lond.) (1999) [Pubmed]
  11. Rotational dynamics of actin-bound intermediates of the myosin adenosine triphosphatase cycle in myofibrils. Berger, C.L., Thomas, D.D. Biophys. J. (1994) [Pubmed]
  12. Adenosine-5'-O-(3-thiotriphosphate) binding to human neutrophils. Evidence for a common nucleotide receptor. Yu, G.H., Tarapchak, S.J., Walker, B.A., Ward, P.A. Lab. Invest. (1991) [Pubmed]
  13. Dual effects of ATP on phosphatidylinositol breakdown in rat hepatocyte membranes. Ibarrondo, J., Marino, A., Guillon, G., Trueba, M., Macarulla, J.M. Cell. Signal. (1991) [Pubmed]
  14. Contribution of nucleoside diphosphokinase to guanine nucleotide regulation of agonist binding to formyl peptide receptors. Wieland, T., Bremerich, J., Gierschik, P., Jakobs, K.H. Eur. J. Pharmacol. (1991) [Pubmed]
  15. Post-transcriptional transfer of gamma-thio affinity label to RNA in isolated parsley nuclei. Schweizer, P., Hahlbrock, K. Plant Mol. Biol. (1993) [Pubmed]
  16. Extracellular nucleotides activate the p38-stress-activated protein kinase cascade in glomerular mesangial cells. Huwiler, A., Wartmann, M., van den Bosch, H., Pfeilschifter, J. Br. J. Pharmacol. (2000) [Pubmed]
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