Disease relevance of Noctyn

• Altered pharmacokinetic-pharmacodynamic relationship of heptabarbital in experimental renal failure in rats [1].
• Kinetics of drug action in disease states. XXIX. Effect of experimental nephrotic syndrome on the pharmacodynamics of heptabarbital: implications of severe hypoalbuminemia [2].
• The present study aimed to investigate whether the pharmacodynamics of a lipophilic barbiturate, heptabarbital, is altered by liver dysfunction [3].

High impact information on Noctyn

• Serum protein binding of heptabarbital was reduced from 49% in controls to 26% in NS rats [2].
• Application of serial sampling of cerebrospinal fluid in pharmacodynamic studies with a drug active in the CNS: heptabarbital concentrations at onset and offset of loss of righting reflex in rats [4].
• The pharmacokinetics of hexobarbital and heptabarbital were studied after simultaneous oral administration to rats in order to correlate their rates of metabolism [5].
• Other cyclosporine-treated and control groups were infused with heptabarbital until they lost their righting reflex [6].
• Compared with controls, cyclosporine-pretreated rats awoke (after heptabarbital injection) and went to sleep (after heptabarbital infusion) with significantly lower barbiturate concentrations in serum and CSF [6].

Biological context of Noctyn

• Pharmacokinetics and relative bioavailability of heptabarbital and heptabarbital sodium after oral administration to man [7].
• The possibility of enzyme induction should be considered when heptabarbital is taken regularly [7].
• Pretreatment of the animals with 20 mg/kg heptabarbital twice dialy for three days prior to the administration of 50 mg/kg BHC resulted in a 40% decrease from controls in the area under the BHC plasma concentration time curve (AUC) [8].

Anatomical context of Noctyn

• 2. The half-lives and clearance values, relative to heptabarbital, determined in hepatocytes were similar to the values obtained with isolated perfused rat liver [9].
• Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of heptabarbital using aperiodic EEG analysis [10].

Associations of Noctyn with other chemical compounds

• Pharmacokinetics of simultaneously administered hexobarbital and heptabarbital in rats: an alternative approach to metabolic correlation studies [5].
• The influence of oral administration of heptabarbital on the gastrointestinal absorption of bishydroxycoumarin (BHC) was investigated in rats [8].

Analytical, diagnostic and therapeutic context of Noctyn

• Liquid chromatography-thermospray tandem mass spectrometry for identification of a heptabarbital metabolite and sample work-up artefacts [11].
• The EEG parameters responded both qualitatively and quantitatively different to increasing concentrations of heptabarbital [10].
• Male Wistar rats (n = 10) received an intravenous infusion of heptabarbital at a rate of 6-9 mg/kg per min until burst suppression with isoelectric periods of 5 sec or longer [10].

References