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Chemical Compound Review

AGN-PC-00MJ5Z     3-hydroxypentanoic acid

Synonyms: HMDB00531, AC1Q5VDO, LMFA01050008, AR-1F3803, AKOS011682998, ...
 
 
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Disease relevance of LMFA01050008

 

High impact information on LMFA01050008

  • Recombinant Escherichia coli fadR atoC(Con) mutants containing the polyhydroxyalkanoate (PHA) biosynthesis genes from Alcaligenes eutrophus are able to incorporate significant levels of 3-hydroxyvalerate (3HV) into the copolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(3HB-co-3HV)] [6].
  • A natural polyester (Biopol), 8% 3-hydroxyvalerate-component (D400G) and a conventional biodegradable polycaprolactone (PCL) were studied, both nanostructured and native forms, in vitro and in vivo [7].
  • A novel copolymer that consisted of 3-hydroxyvalerate and 4-hydroxybutyrate, P(3HV-co-4HB), was synthesized in Hydrogenophaga pseudoflava by growing it in media containing gamma-valerolactone and gamma-butyrolactone as a carbon source [8].
  • In Escherichia coli carrying the poly(3-hydroxyalkanoate) (PHA) biosynthesis pathway on a plasmid (pha+), the function of the ackA (acetate kinase) and pta (phosphotransacetylase) genes is necessary for efficient incorporation of 3-hydroxyvalerate (3-HV) into the copolymer, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (P(3HB-co-3HV)) [9].
  • For the NREL CF hydrolysate-based cultures amended with 0.25-0.5% LA, P(3HB-co-3HV) yields, PHA contents (PHA as percent of dry biomass), and mol% 3HV compositions of 2.0 g/l, 40% (w/w), and 16-52 mol% were obtained, respectively [10].
 

Chemical compound and disease context of LMFA01050008

 

Associations of LMFA01050008 with other chemical compounds

  • For quantification of 3HB and 3HV directly from digested sludge, a method based on ion-exchange chromatography and conductivity detection was developed (IC-method) [12].
 

Analytical, diagnostic and therapeutic context of LMFA01050008

References

  1. High-level production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) by fed-batch culture of recombinant Escherichia coli. Choi, J.I., Lee, S.Y. Appl. Environ. Microbiol. (1999) [Pubmed]
  2. Identification of the 2-methylcitrate pathway involved in the catabolism of propionate in the polyhydroxyalkanoate-producing strain Burkholderia sacchari IPT101(T) and analysis of a mutant accumulating a copolyester with higher 3-hydroxyvalerate content. Brämer, C.O., Silva, L.F., Gomez, J.G., Priefert, H., Steinbüchel, A. Appl. Environ. Microbiol. (2002) [Pubmed]
  3. Cometabolic biosynthesis of copolyesters consisting of 3-hydroxyvalerate and medium-chain-length 3-hydroxyalkanoates by Pseudomonas sp. DSY-82. Kang, H.O., Chung, C.W., Kim, H.W., Kim, Y.B., Rhee, Y.H. Antonie Van Leeuwenhoek (2001) [Pubmed]
  4. Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) by metabolically engineered Escherichia coli strains. Park, S.J., Ahn, W.S., Green, P.R., Lee, S.Y. Biotechnol. Bioeng. (2001) [Pubmed]
  5. Accumulation of a poly(hydroxyalkanoate) copolymer containing primarily 3-hydroxyvalerate from simple carbohydrate substrates by Rhodococcus sp. NCIMB 40126. Haywood, G.W., Anderson, A.J., Williams, D.R., Dawes, E.A., Ewing, D.F. Int. J. Biol. Macromol. (1991) [Pubmed]
  6. Role of fadR and atoC(Con) mutations in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthesis in recombinant pha+ Escherichia coli. Rhie, H.G., Dennis, D. Appl. Environ. Microbiol. (1995) [Pubmed]
  7. In vitro and in vivo response to nanotopographically-modified surfaces of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and polycaprolactone. Giavaresi, G., Tschon, M., Daly, J.H., Liggat, J.J., Sutherland, D.S., Agheli, H., Fini, M., Torricelli, P., Giardino, R. Journal of biomaterials science. Polymer edition (2006) [Pubmed]
  8. Biosynthesis and local sequence specific degradation of poly(3-hydroxyvalerate-co-4-hydroxybutyrate) in Hydrogenophaga pseudoflava. Choi, M.H., Lee, H.J., Rho, J.K., Yoon, S.C., Nam, J.D., Lim, D., Lenz, R.W. Biomacromolecules (2003) [Pubmed]
  9. The function of ackA and pta genes is necessary for poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthesis in recombinant pha+ Escherichia coli. Rhie, H.G., Dennis, D. Can. J. Microbiol. (1995) [Pubmed]
  10. Polyhydroxyalkanoate copolymers from forest biomass. Keenan, T.M., Nakas, J.P., Tanenbaum, S.W. J. Ind. Microbiol. Biotechnol. (2006) [Pubmed]
  11. Enhanced biosynthesis of polyhydroxyalkanoates in a mutant strain of Rhizobium meliloti. Lakshman, K., Shamala, T.R. Biotechnol. Lett. (2003) [Pubmed]
  12. Determination of polyhydroxyalkanoates in activated sludge by ion chromatographic and enzymatic methods. Hesselmann, R.P., Fleischmann, T., Hany, R., Zehnder, A.J. J. Microbiol. Methods (1999) [Pubmed]
  13. Isolation and 1H-NMR spectroscopic identification of poly(3-hydroxybutanoate) from prokaryotic and eukaryotic organisms. Determination of the absolute configuration (R) of the monomeric unit 3-hydroxybutanoic acid from Escherichia coli and spinach. Seebach, D., Brunner, A., Bürger, H.M., Schneider, J., Reusch, R.N. Eur. J. Biochem. (1994) [Pubmed]
 
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