The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AGN-PC-00MJ5Z     3-hydroxypentanoic acid

Synonyms: HMDB00531, AC1Q5VDO, LMFA01050008, AR-1F3803, AKOS011682998, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LMFA01050008


High impact information on LMFA01050008

  • Recombinant Escherichia coli fadR atoC(Con) mutants containing the polyhydroxyalkanoate (PHA) biosynthesis genes from Alcaligenes eutrophus are able to incorporate significant levels of 3-hydroxyvalerate (3HV) into the copolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(3HB-co-3HV)] [6].
  • A natural polyester (Biopol), 8% 3-hydroxyvalerate-component (D400G) and a conventional biodegradable polycaprolactone (PCL) were studied, both nanostructured and native forms, in vitro and in vivo [7].
  • A novel copolymer that consisted of 3-hydroxyvalerate and 4-hydroxybutyrate, P(3HV-co-4HB), was synthesized in Hydrogenophaga pseudoflava by growing it in media containing gamma-valerolactone and gamma-butyrolactone as a carbon source [8].
  • In Escherichia coli carrying the poly(3-hydroxyalkanoate) (PHA) biosynthesis pathway on a plasmid (pha+), the function of the ackA (acetate kinase) and pta (phosphotransacetylase) genes is necessary for efficient incorporation of 3-hydroxyvalerate (3-HV) into the copolymer, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (P(3HB-co-3HV)) [9].
  • For the NREL CF hydrolysate-based cultures amended with 0.25-0.5% LA, P(3HB-co-3HV) yields, PHA contents (PHA as percent of dry biomass), and mol% 3HV compositions of 2.0 g/l, 40% (w/w), and 16-52 mol% were obtained, respectively [10].

Chemical compound and disease context of LMFA01050008


Associations of LMFA01050008 with other chemical compounds

  • For quantification of 3HB and 3HV directly from digested sludge, a method based on ion-exchange chromatography and conductivity detection was developed (IC-method) [12].

Analytical, diagnostic and therapeutic context of LMFA01050008


  1. High-level production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) by fed-batch culture of recombinant Escherichia coli. Choi, J.I., Lee, S.Y. Appl. Environ. Microbiol. (1999) [Pubmed]
  2. Identification of the 2-methylcitrate pathway involved in the catabolism of propionate in the polyhydroxyalkanoate-producing strain Burkholderia sacchari IPT101(T) and analysis of a mutant accumulating a copolyester with higher 3-hydroxyvalerate content. Brämer, C.O., Silva, L.F., Gomez, J.G., Priefert, H., Steinbüchel, A. Appl. Environ. Microbiol. (2002) [Pubmed]
  3. Cometabolic biosynthesis of copolyesters consisting of 3-hydroxyvalerate and medium-chain-length 3-hydroxyalkanoates by Pseudomonas sp. DSY-82. Kang, H.O., Chung, C.W., Kim, H.W., Kim, Y.B., Rhee, Y.H. Antonie Van Leeuwenhoek (2001) [Pubmed]
  4. Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) by metabolically engineered Escherichia coli strains. Park, S.J., Ahn, W.S., Green, P.R., Lee, S.Y. Biotechnol. Bioeng. (2001) [Pubmed]
  5. Accumulation of a poly(hydroxyalkanoate) copolymer containing primarily 3-hydroxyvalerate from simple carbohydrate substrates by Rhodococcus sp. NCIMB 40126. Haywood, G.W., Anderson, A.J., Williams, D.R., Dawes, E.A., Ewing, D.F. Int. J. Biol. Macromol. (1991) [Pubmed]
  6. Role of fadR and atoC(Con) mutations in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthesis in recombinant pha+ Escherichia coli. Rhie, H.G., Dennis, D. Appl. Environ. Microbiol. (1995) [Pubmed]
  7. In vitro and in vivo response to nanotopographically-modified surfaces of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and polycaprolactone. Giavaresi, G., Tschon, M., Daly, J.H., Liggat, J.J., Sutherland, D.S., Agheli, H., Fini, M., Torricelli, P., Giardino, R. Journal of biomaterials science. Polymer edition (2006) [Pubmed]
  8. Biosynthesis and local sequence specific degradation of poly(3-hydroxyvalerate-co-4-hydroxybutyrate) in Hydrogenophaga pseudoflava. Choi, M.H., Lee, H.J., Rho, J.K., Yoon, S.C., Nam, J.D., Lim, D., Lenz, R.W. Biomacromolecules (2003) [Pubmed]
  9. The function of ackA and pta genes is necessary for poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthesis in recombinant pha+ Escherichia coli. Rhie, H.G., Dennis, D. Can. J. Microbiol. (1995) [Pubmed]
  10. Polyhydroxyalkanoate copolymers from forest biomass. Keenan, T.M., Nakas, J.P., Tanenbaum, S.W. J. Ind. Microbiol. Biotechnol. (2006) [Pubmed]
  11. Enhanced biosynthesis of polyhydroxyalkanoates in a mutant strain of Rhizobium meliloti. Lakshman, K., Shamala, T.R. Biotechnol. Lett. (2003) [Pubmed]
  12. Determination of polyhydroxyalkanoates in activated sludge by ion chromatographic and enzymatic methods. Hesselmann, R.P., Fleischmann, T., Hany, R., Zehnder, A.J. J. Microbiol. Methods (1999) [Pubmed]
  13. Isolation and 1H-NMR spectroscopic identification of poly(3-hydroxybutanoate) from prokaryotic and eukaryotic organisms. Determination of the absolute configuration (R) of the monomeric unit 3-hydroxybutanoic acid from Escherichia coli and spinach. Seebach, D., Brunner, A., Bürger, H.M., Schneider, J., Reusch, R.N. Eur. J. Biochem. (1994) [Pubmed]
WikiGenes - Universities