Disease relevance of Placcel M

• The rate of weight loss was greater and the period prior to weight loss was shorter when the comonomer content of copolymers of epsilon-caprolactone was sufficient to reduce the melting point of epsilon-caproate sequences to body temperature [1].
• The purpose of the current study was to show the efficacy and safety of an absorbable polymer (polycaprolactone) as an antibiotic delivery vehicle for treatment of osteomyelitis [2].
• We have studied the enzymatic Baeyer-Villiger oxidation of cyclohexanone as a model for this class of reactions and developed a simple approach that uses whole, non-growing Escherichia coli cells to provide high productivity (0.79 g epsilon-caprolactone/L/h = 18 micromol epsilon-caprolactone/min/g dcw) and an 88% yield [3].
• Polycaprolactone depolymerase produced by the bacterium Alcaligenes faecalis [4].
• SIGNIFICANCE AND IMPACT OF THE STUDY: Bacillus cereus UW85 produced tercopolymer with a low molecular weight from one substrate (epsilon-caprolactone) used as a carbon source [5].

Psychiatry related information on Placcel M

• A limit for MPEG initiator esterification in lipase-catalyzed CL polymerization was observed and was explained by preferential reaction of PCL propagation over MPEG esterification at long reaction times and low MPEG concentrations [6].

High impact information on Placcel M

• The complexes Fe2(OCHPh2)6 and L2FeOR (R = Et or CHPh2, L = N,N'-bis(trimethylsilyl)benzamidinate) were structurally characterized, and comparative studies of the behavior of those compounds comprising the same alkoxide (Ph2HCO-) in polymerizations of -caprolactone (CL) and D,L-lactide (LA) were performed [7].
• We established histopathologic and neurophysiologic approaches to examine whether different designs of polycaprolactone-engineered nerve conduits (hollow vs. laminated) could promote nerve regeneration as autologous grafts after transection of sciatic nerves [8].
• Chinese hamster ovary (CHO) cells transfected with the plasmid hANP-cDNA were encapsulated in biocompatible polycaprolactone capsules for intraperitoneal implantation into two-kidney, one-clip (2K1C) hypertensive rats [9].
• CHO cells transfected with the plasmid CMV-cANP were encapsulated in biocompatible polycaprolactone (PCL) capsules, and then the PCL capsules were implanted into 2K1C hypertensive rats intraperitoneally [10].
• The purpose of this work was to assess the immunogenicity of a single nasal or oral administration of recombinant 28-kDa glutathione S-transferase of Schistosoma mansoni (rSm28GST) entrapped by poly(lactide-co-glycolide) (PLG)- or polycaprolactone (PCL)-biodegradable microparticles [11].

Chemical compound and disease context of Placcel M

• We have shown that whole Escherichia coli cells overexpressing NADPH-dependent cyclohexanone monooxygenase carry out a model Baeyer-Villiger oxidation with high volumetric productivity (0.79 g epsilon-caprolactone/L.h ) under nongrowing conditions (Walton, A. Z.; Stewart, J. D. Biotechnol. Prog. 2002, 18, 262-268) [12].
• An intramedullary osteomyelitis was induced in the femur of adult rabbits by Staphylococcus aureus inoculation after use of a sclerosing agent, and then treatment was done with intramedullary irrigation and implantation of a rod made of polycaprolactone, polycaprolactone plus 6% tobramycin, or polymethylmethacrylate plus 6% tobramycin [2].
• DESIGN AND METHODS: Minocycline (1.4 mg in polycaprolactone vehicle) and control strips were applied into all residual pockets (PD > or = 5mm, > or =2 pockets/subject) of patients with chronic periodontitis 1 month after a course of non-surgical periodontal therapy [13].

Biological context of Placcel M

• The dimeric ester of hydroxyhexanoate was the main product of enzymatic hydrolysis of polycaprolactone by P. aeruginosa lipase [14].
• Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers [15].
• Decreased fibroblast cell density on chemically degraded poly-lactic-co-glycolic acid, polyurethane, and polycaprolactone [16].
• In a 3-D environment, cell-seeded PCL scaffolds evaluated by confocal laser microscopy revealed continuous cell proliferation and homogeneous cell distribution within the PCL scaffolds [17].
• The aim of this research is to develop polymeric micelle system as a targetable bone imaging carriers without nonspecific phagocytosis which is made of polyethylene oxide (PEO) and polycaprolactone (PCL) [18].

Anatomical context of Placcel M

• The effect of irradiation modification and RGD sequence adsorption on the response of human osteoblasts to polycaprolactone [19].
• The present investigation shows that PCL-coated collagen matrices are suitable for fibroblast growth, proliferation, and migration inside the matrices [20].
• RESULTS: In the initial study, the SPP and silicone membranes remained intact, but the PCL covering broke in all dogs [21].
• Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering [22].
• Gravity spun polycaprolactone fibers for applications in vascular tissue engineering: proliferation and function of human vascular endothelial cells [23].

Associations of Placcel M with other chemical compounds

• Synthesis and in vitro drug release behavior of amphiphilic triblock copolymer nanoparticles based on poly (ethylene glycol) and polycaprolactone [24].
• The monooxygenase catalyses the transformation of cyclohexanone to the lactone 1-oxa-2-oxocycloheptane in an oxygen ring insertion reaction [25].
• Microporous, elastomeric, biofragmentable polyurethane-based prostheses and microporous, elastomeric, biodegradable prostheses made of poly-epsilon-caprolactone or a copolymer of epsilon-caprolactone and 3.6-dimethyl-1,4-morpholine-2,5-dione with a monomer ratio of 95.5:4.5 were prepared [26].
• In this study, elastomeric D,L-lactide and epsilon-caprolactone copolymers with two different molecular weights (Mn: 108.000 and 40.000) were synthesized by ring-opening polymerization of the respective dimers by using stannous octoate as the catalyst, as a potential bone-filling material [27].
• In order to evaluate the repair potential in large osteochondral defects on high load-bearing sites, a hybrid scaffold system was made of three-dimensional porous Polycaprolactone (PCL) scaffold for the cartilage and tricalcium phosphate-reinforced PCL for the bone portion [28].

Gene context of Placcel M

• Pooled 10-week sera from mice receiving PLG microparticles by the nasal or oral route neutralized the rSm28GST enzymatic activity, whereas sera of mice receiving either PCL microparticles, free rSm28GST, or empty microparticles inefficiently neutralized this enzymatic activity [11].
• In vitro studies showed that the biodegradable polymer poly (Ghlr epsilon epsilon-caprolactone) (PCL) released BMOV in a sustained manner with rates of drug release increasing with increased loading of the drug in the polymer [29].
• Light, environmental scanning electron, and confocal laser microscopy as well as immunohistochemistry showed cell proliferation and extracellular matrix production on the polycaprolactone surface in the 1st culturing week [30].
• The implanted PLCL scaffolds displayed a slow degradation on time, where caprolactone units were faster degraded than lactide did [31].
• However, there was a disproportionate synthesis of CE per mg of total protein on PS and TDI/PCL/ED whereas on PTMO there was not [32].

Analytical, diagnostic and therapeutic context of Placcel M

• A novel degradable polycaprolactone networks for tissue engineering [33].
• MATERIALS AND METHODS: Initially, stents (10 x 6 mm) covered with polycaprolactone (PCL), segmented polyether polyurethane (SPP), and silicone were placed in the common bile duct of dogs and were followed up for 3-12 months [21].
• The application of microspheres from the copolymers of lactide and epsilon-caprolactone to the controlled release of steroids [34].
• Surface modification of polycaprolactone with poly(methacrylic acid) and gelatin covalent immobilization for promoting its cytocompatibility [35].
• Our cell culture study shows that fibroblasts and osteoblast-like cells can proliferate, differentiate, and produce a cellular tissue in an entirely interconnected 3D polycaprolactone matrix [30].

References