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Chemical Compound Review

PubChem20027     4-propan-2-ylbenzoic acid

Synonyms: Cuminic acid, AGN-PC-0D8B4W, CHEMBL116158, SureCN105270, NSC-1907, ...
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Disease relevance of NSC1907

  • Pseudomonas putida F1 utilizes p-cumate (p-isopropylbenzoate) as a growth substrate by means of an eight-step catabolic pathway [1].
  • Functional identification of p-cumate operons in the terpene-degrading Rhodococcus sp. strain T104 [2].
  • Rhodopseudomonas palustris utilizes p-cumate as a carbon source both under anaerobic light and aerobic dark conditions [3].
  • Intermediate products of p-cumate degradation could be detected from extracts of Escherichia coli heterologously expressing the first 5 genes responsible for the first two steps of p-cumate degradation in R. palustris [3].

High impact information on NSC1907

  • p-Cymene catabolic pathway in Pseudomonas putida F1: cloning and characterization of DNA encoding conversion of p-cymene to p-cumate [4].
  • A 35.75-kb DNA segment, within which the cmt operon encoding the catabolism of p-cumate is located, was cloned as four separate overlapping restriction fragments and mapped with restriction endonucleases [1].
  • Selective enrichment of the mutants and for strains putatively cured of a degradative plasmid was achieved by incubation of cells in minimal growth media containing p-cymene (or p-cumate) and various halogenated analogs of the growth substrates or pathway intermediates [5].
  • We identified a p-cumate degrading gene cluster (designated cmt) with a novel organization in our genomic studies of the terpene-degrading Rhodococcus sp. strain T104 [2].
  • The mutant strain SN140, isolated for the inability to grow on p-cumate, accumulates 2,3-dihydroxy-p-cumate as identified by liquid chromatography-mass spectrometry and 300 MHz proton nuclear magnetic resonance spectroscopy [2].

Chemical compound and disease context of NSC1907


Biological context of NSC1907


Associations of NSC1907 with other chemical compounds


Analytical, diagnostic and therapeutic context of NSC1907


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