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Chemical Compound Review:

KBioGR_000203 7-[(1S,2S,3R,5S)-3,5- dihydroxy-2-[(3S)-3...

Synonyms: KBioSS_000203, CBiol_002031, CTK1A4660, KBio2_000203, KBio2_002771, ...

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Disease relevance of C13809

Revascularization decreases 8-isoprostaglandin F2alpha excretion in chronic lower limb ischemia [1].
This study aims to measure the levels of 8-isoprostaglandin F2alpha, an isoprostane widely studied in other models as a by-product of ROS-induced lipid peroxidation, in basal cell carcinoma and in UVA irradiated healthy skin [2].

High impact information on C13809

Correlation between 8-isoprostaglandin-F2alpha level and von Willebrand factor narrowly failed to reach statistical significance (P = 0.05) [3].
The formation of 8-isoprostaglandin F2alpha in lipopolysaccharide-induced air pouch model and the inhibition of its production by various cyclooxygenase inhibitors provide evidence for cyclooxygenase-dependent formation of isoprostanes in this model [4].
To investigate a possible role of 8-isoprostaglandin F2alpha in inflammation, 8-isoprostaglandin F2alpha and prostaglandin E2 levels were determined by enzyme immunoassay (EIA) in carrageenan-induced air pouch model in rats [4].
Excretion of 8-isoprostaglandin F2alpha (8-Iso) and malonyldialdehyde (MDA) were related to renal cortical mRNA abundance for subunits of NADPH oxidase and superoxide dismutases (SODs) using real-time PCR [5].
Effect of 8-isoprostaglandin F2alpha on the newborn rat pulmonary arterial muscle and endothelium [6].

Biological context of C13809

We suggest that, as assessed by the quantitation of urinary 8-isoprostaglandin F2alpha, chronic lower limb ischemia is associated with increased oxidative stress, which is decreased by revascularization [1].
Urinary 8-isoprostaglandin F2alpha is a new marker which reflects oxidative stress in vivo and can be utilized as a diagnostic tool to assess the extent of oxidative stress in various disease states associated with lipid peroxidation [1].

Associations of C13809 with other chemical compounds

Urinary 8-isoprostaglandin F2alpha was extracted on a C2 silica cartridge and determinated by radioimmunoassay [1].

Gene context of C13809

Tempol also significantly decreased the level of 8-isoprostaglandin F2alpha in the endothelin-1-treated rats [7].

Analytical, diagnostic and therapeutic context of C13809

Increased levels of 8-isoprostaglandin F2alpha in cardiac ischemia/reperfusion provide evidence for oxidative stress during coronary perfusion [1].

References

Revascularization decreases 8-isoprostaglandin F2alpha excretion in chronic lower limb ischemia. Rossi, P., Riutta, A., Kuukasjärvi, P., Vehmas, T., Mucha, I., Salenius, J.P. Prostaglandins Leukot. Essent. Fatty Acids (2004) [Pubmed]
Elevated 8-isoprostane levels in basal cell carcinoma and in UVA irradiated skin. Belli, R., Amerio, P., Brunetti, L., Orlando, G., Toto, P., Proietto, G., Vacca, M., Tulli, A. International journal of immunopathology and pharmacology. (2005) [Pubmed]
Levels of F2-isoprostanes in systemic sclerosis: correlation with clinical features. Volpe, A., Biasi, D., Caramaschi, P., Mantovani, W., Bambara, L.M., Canestrini, S., Ferrari, M., Poli, G., Degan, M., Carletto, A., Pieropan, S., Minuz, P. Rheumatology (Oxford, England) (2006) [Pubmed]
Formation of 8-isoprostaglandin F2alpha and prostaglandin E2 in carrageenan-induced air pouch model in rats. Ciçek Ozdöl, N., Melli, M. Eur. J. Pharmacol. (2004) [Pubmed]
Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression. Chabrashvili, T., Kitiyakara, C., Blau, J., Karber, A., Aslam, S., Welch, W.J., Wilcox, C.S. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003) [Pubmed]
Effect of 8-isoprostaglandin F2alpha on the newborn rat pulmonary arterial muscle and endothelium. Belik, J., Jankov, R.P., Pan, J., Yi, M., Pace-Asciak, C.R., Tanswell, A.K. J. Appl. Physiol. (2003) [Pubmed]
Role of reactive oxygen species in endothelin-induced hypertension. Sedeek, M.H., Llinas, M.T., Drummond, H., Fortepiani, L., Abram, S.R., Alexander, B.T., Reckelhoff, J.F., Granger, J.P. Hypertension (2003) [Pubmed]

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