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Chemical Compound Review

Fprmecl     (2S)-N-[(1S)-1-[[(3S)-1- chloro-6...

Synonyms: FPRCK, Phe-pro-arg-CK, AC1L3GOH, LS-176430, C21H29ClN6O5, ...
 
 
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Disease relevance of Fprmecl

  • To evaluate the relative antithrombotic efficacy and hemostatic safety of antithrombin therapy for vascular thrombus formation at sites of mechanical vascular injury, we administered the potent and specific irreversible synthetic antithrombin D-PHE-PRO-ARG chloromethyl ketone (D-FPRCH2Cl) after performing carotid endarterectomies in baboons [1].
  • After 48 h, alpha Th induced hypertrophy, sarcomeric organization, and enhanced atrial natriuretic factor (ANF) expression, all of which were blocked by the alpha Th-selective protease inhibitor, D-Phe-Pro-Arg-chloromethyl ketone [2].
 

High impact information on Fprmecl

 

Biological context of Fprmecl

 

Anatomical context of Fprmecl

 

Associations of Fprmecl with other chemical compounds

References

  1. Lasting safe interruption of endarterectomy thrombosis by transiently infused antithrombin peptide D-Phe-Pro-ArgCH2Cl in baboons. Lumsden, A.B., Kelly, A.B., Schneider, P.A., Krupski, W.C., Dodson, T., Hanson, S.R., Harker, L.A. Blood (1993) [Pubmed]
  2. Myocardial alpha-thrombin receptor activation induces hypertrophy and increases atrial natriuretic factor gene expression. Glembotski, C.C., Irons, C.E., Krown, K.A., Murray, S.F., Sprenkle, A.B., Sei, C.A. J. Biol. Chem. (1993) [Pubmed]
  3. Effect of thrombin, the thrombin receptor activation peptide, and other mitogens on vascular smooth muscle cell urokinase receptor mRNA levels. Reuning, U., Little, S.P., Dixon, E.P., Bang, N.U. Blood (1994) [Pubmed]
  4. Comparative behavior of thrombin and an inactive derivative, FPR-thrombin, toward the rabbit vascular endothelium. Heparin liberates FPR-thrombin from the endothelium in vivo. Hatton, M.W., Moar, S.L. Circ. Res. (1990) [Pubmed]
  5. Thrombin and histamine stimulate the phosphorylation of elongation factor 2 in human umbilical vein endothelial cells. Mackie, K.P., Nairn, A.C., Hampel, G., Lam, G., Jaffe, E.A. J. Biol. Chem. (1989) [Pubmed]
  6. Anophelin: kinetics and mechanism of thrombin inhibition. Francischetti, I.M., Valenzuela, J.G., Ribeiro, J.M. Biochemistry (1999) [Pubmed]
  7. Human pregnancy serum contains at least two distinct proteolytic activities with the ability to degrade insulin-like growth factor binding protein-3. Bang, P., Fielder, P.J. Endocrinology (1997) [Pubmed]
  8. The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin. Vijayalakshmi, J., Padmanabhan, K.P., Mann, K.G., Tulinsky, A. Protein Sci. (1994) [Pubmed]
  9. Tissue plasminogen activator (tPA) inhibits human neutrophil superoxide anion production in vitro. Stringer, K.A., Lindenfeld, J., Repine, A.J., Cohen, Z., Repine, J.E. Inflammation (1997) [Pubmed]
  10. Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors. Qiu, X., Padmanabhan, K.P., Carperos, V.E., Tulinsky, A., Kline, T., Maraganore, J.M., Fenton, J.W. Biochemistry (1992) [Pubmed]
  11. Thrombin inactivates acidic fibroblast growth factor but not basic fibroblast growth factor. Lobb, R.R. Biochemistry (1988) [Pubmed]
  12. Protease inhibitors influence the direction of neurite outgrowth. Hawkins, R.L., Seeds, N.W. Brain Res. Dev. Brain Res. (1989) [Pubmed]
 
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