The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Fprmecl     (2S)-N-[(1S)-1-[[(3S)-1- chloro-6...

Synonyms: FPRCK, Phe-pro-arg-CK, AC1L3GOH, LS-176430, C21H29ClN6O5, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Fprmecl

  • To evaluate the relative antithrombotic efficacy and hemostatic safety of antithrombin therapy for vascular thrombus formation at sites of mechanical vascular injury, we administered the potent and specific irreversible synthetic antithrombin D-PHE-PRO-ARG chloromethyl ketone (D-FPRCH2Cl) after performing carotid endarterectomies in baboons [1].
  • After 48 h, alpha Th induced hypertrophy, sarcomeric organization, and enhanced atrial natriuretic factor (ANF) expression, all of which were blocked by the alpha Th-selective protease inhibitor, D-Phe-Pro-Arg-chloromethyl ketone [2].

High impact information on Fprmecl


Biological context of Fprmecl


Anatomical context of Fprmecl


Associations of Fprmecl with other chemical compounds


  1. Lasting safe interruption of endarterectomy thrombosis by transiently infused antithrombin peptide D-Phe-Pro-ArgCH2Cl in baboons. Lumsden, A.B., Kelly, A.B., Schneider, P.A., Krupski, W.C., Dodson, T., Hanson, S.R., Harker, L.A. Blood (1993) [Pubmed]
  2. Myocardial alpha-thrombin receptor activation induces hypertrophy and increases atrial natriuretic factor gene expression. Glembotski, C.C., Irons, C.E., Krown, K.A., Murray, S.F., Sprenkle, A.B., Sei, C.A. J. Biol. Chem. (1993) [Pubmed]
  3. Effect of thrombin, the thrombin receptor activation peptide, and other mitogens on vascular smooth muscle cell urokinase receptor mRNA levels. Reuning, U., Little, S.P., Dixon, E.P., Bang, N.U. Blood (1994) [Pubmed]
  4. Comparative behavior of thrombin and an inactive derivative, FPR-thrombin, toward the rabbit vascular endothelium. Heparin liberates FPR-thrombin from the endothelium in vivo. Hatton, M.W., Moar, S.L. Circ. Res. (1990) [Pubmed]
  5. Thrombin and histamine stimulate the phosphorylation of elongation factor 2 in human umbilical vein endothelial cells. Mackie, K.P., Nairn, A.C., Hampel, G., Lam, G., Jaffe, E.A. J. Biol. Chem. (1989) [Pubmed]
  6. Anophelin: kinetics and mechanism of thrombin inhibition. Francischetti, I.M., Valenzuela, J.G., Ribeiro, J.M. Biochemistry (1999) [Pubmed]
  7. Human pregnancy serum contains at least two distinct proteolytic activities with the ability to degrade insulin-like growth factor binding protein-3. Bang, P., Fielder, P.J. Endocrinology (1997) [Pubmed]
  8. The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin. Vijayalakshmi, J., Padmanabhan, K.P., Mann, K.G., Tulinsky, A. Protein Sci. (1994) [Pubmed]
  9. Tissue plasminogen activator (tPA) inhibits human neutrophil superoxide anion production in vitro. Stringer, K.A., Lindenfeld, J., Repine, A.J., Cohen, Z., Repine, J.E. Inflammation (1997) [Pubmed]
  10. Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors. Qiu, X., Padmanabhan, K.P., Carperos, V.E., Tulinsky, A., Kline, T., Maraganore, J.M., Fenton, J.W. Biochemistry (1992) [Pubmed]
  11. Thrombin inactivates acidic fibroblast growth factor but not basic fibroblast growth factor. Lobb, R.R. Biochemistry (1988) [Pubmed]
  12. Protease inhibitors influence the direction of neurite outgrowth. Hawkins, R.L., Seeds, N.W. Brain Res. Dev. Brain Res. (1989) [Pubmed]
WikiGenes - Universities