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Chemical Compound Review

CARBARYL     naphthalen-1-yl N-methylcarbamate

Synonyms: Caprolin, Carbaril, Carbatox, Carbavur, Carpolin, ...
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Disease relevance of Gamonil


High impact information on Gamonil

  • However, at a concentration of 10 ppm, significant inhibition in production of aflatoxins was found only with naled, dichlorvos, Sevin, Landrin, and pyrethrum [6].
  • The ATP-chemosensitivity assay as previously described (Sevin et al. Gynecol. Oncol. 31, 191-204, 1988) was used to determine the cytotoxic effect of U-73 and DDP [7].
  • Influence of irrigation methods and use of an adjuvant on the persistence of the carbaryl (1-naphthyl N-methylcarbamate) on pakchoi [Brassica rapa L. subsp. chinensis (Rupr.) Olsson] was studied using a commercial enzyme linked immunosorbent assay kit [8].
  • When operated at optimized conditions, the biosensor measured as low as 55 ppb of paraoxon, 53 ppb of methyl parathion, and 58 ppb of parathion without interference from most phenolic compounds and other commonly used pesticides, such as atrazine, coumaphos, sutan, sevin, and diazinon [9].
  • We investigated bioavailability and biodegradation of carbaryl (1-naphthyl methylcarbamate) in a soil with a long history of pesticide contamination from a storage facility located at Mamoon Kanjan, Pakistan. Carbaryl is weakly sorbed and generally considered to be easily degradable in soil [10].

Chemical compound and disease context of Gamonil


Biological context of Gamonil

  • In addition, as minnows are lower on the food chain, bioaccumulation of Sevin in tissues may increase in larger predators, affecting their metabolism and reproduction [13].
  • Residues of carbaryl and two of its metabolites in eggs of laying hens treated with Sevin for northern fowl mite control by dipping [14].
  • The effects of carbaryl (1-naphthalenyl methylcarbamate), commonly used in agricultural operations, have been studied with reference to survival, behavior, food intake, growth, and conversion efficiency of the catfish Mystus vittatus [15].
  • The method was evaluated by studying chemically induced DNA damage by using both organochloride (2,4-dichlorophenoxyacetic acid and lindane) and organophosphorus (sevin and phosphamidon) compounds at different concentrations [16].
  • Basagran, Sevin, and Bravo increased the amination activities of GDH from 30.0 +/- 2.8 units in the control assay to 479.0 +/- 20.7, 63.0 +/- 5.8, and 35.2 +/- 2.2 units, respectively, therefore indicating a direct GDH-pesticide interaction [17].

Anatomical context of Gamonil

  • Patients with small cell carcinoma of the cervix were found to have a very poor prognosis (disease free 5-year survival of 36%) and were also excluded from this analysis (Sevin BU, Nadji M, Metkoch MW, Lu Y, Averette HE. Unpublished data, 1995) [18].
  • The in vitro interaction of the insecticide 1-naphthyl-N-methylcarbamate (carbaryl) with respiration and the glycolytic pathway was studied in hepatocytes isolated according to a modified version of the method of Berry and Friend [19].
  • On the basis of previous observations on the teratogenic effects of a variety of organophosphorus and methylcarbamate compounds on the avian skeletal apparatus, the Meckel's cartilage shape and structure were analyzed in carbaryl (1-naphthyl N-methylcarbamate) treated and control chick embryos of 9, 10, 12 days of incubation [20].
  • A gas chromatography-tandem mass spectrometric (GC-MS/MS) method has been developed for the determination of carbofuran (2,3-dihydro-2,2-dimethylbenzofuran-7-yl methylcarbamate), carbaryl (1-naphthyl-N-methylcarbamate) and their main metabolites in human blood plasma [21].

Associations of Gamonil with other chemical compounds


Gene context of Gamonil

  • Basagran, Sevin, and Bravo possess different pesticidal properties, but their effects on GDH activity were related in the decreasing order of their nucleophilicity, viz [17].
  • The procedure included derivatization of a sample with 6-aminoquinolyl-N-hydroxy-succinimidyl carbomate (AccQ) at 0.20 mol/l borate buffer (pH 8.80) for 30 min at 70 degrees C, and pre-concentration with surfactant cloud point extraction [26].
  • The present investigation addresses the effect of sevin (insecticide) on kinetic parameters of camel retina membrane-bound acetylcholinesterase (AChE, EC [27].

Analytical, diagnostic and therapeutic context of Gamonil


  1. Characterization of varicella-zoster virus enhancement by the pesticide carbaryl. Abrahamsen, L.H., Jerkofsky, M. Appl. Environ. Microbiol. (1983) [Pubmed]
  2. Nucleotide sequence and genetic structure of a novel carbaryl hydrolase gene (cehA) from Rhizobium sp. strain AC100. Hashimoto, M., Fukui, M., Hayano, K., Hayatsu, M. Appl. Environ. Microbiol. (2002) [Pubmed]
  3. Purification and characterization of 1-naphthol-2-hydroxylase from carbaryl-degrading pseudomonas strain c4. Swetha, V.P., Basu, A., Phale, P.S. J. Bacteriol. (2007) [Pubmed]
  4. Nitrosocarbaryl: its effect on human DNA. Regan, J.D., Setlow, R.B., Francis, A.A., Lijinsky, W. Mutat. Res. (1976) [Pubmed]
  5. Increased susceptibility of bobwhites (Colinus virginianus) to Histomonas meleagridis after exposure. Zeakes, S.J., Hansen, H.F., Robel, R.J. Avian Dis. (1981) [Pubmed]
  6. Inhibition of aflatoxin production by selected insecticides. Draughon, F.A., Ayres, J.C. Appl. Environ. Microbiol. (1981) [Pubmed]
  7. Comparison of U-73,975 and cisplatin cytotoxicity in fresh cervical and ovarian carcinoma specimens with the ATP-chemosensitivity assay. Hightower, R.D., Sevin, B.U., Perras, J.P., Untch, M., Angioli, R., Ramos, R., Averette, H. Gynecol. Oncol. (1992) [Pubmed]
  8. Influence of irrigation methods and an adjuvant on the persistence of carbaryl on pakchoi. Marutani, M., Edirveerasingam, V. J. Environ. Qual. (2006) [Pubmed]
  9. Direct determination of p-nitrophenyl substituent organophosphorus nerve agents using a recombinant Pseudomonas putida JS444-modified Clark oxygen electrode. Lei, Y., Mulchandani, P., Chen, W., Mulchandani, A. J. Agric. Food Chem. (2005) [Pubmed]
  10. Aging reduces the bioavailability of even a weakly sorbed pesticide (carbaryl) in soil. Ahmad, R., Kookana, R.S., Megharaj, M., Alston, A.M. Environ. Toxicol. Chem. (2004) [Pubmed]
  11. Cytogenetic effect of some insecticides in mouse spleen. Amer, S.M., Fahmy, M.A., Donya, S.M. Journal of applied toxicology : JAT. (1996) [Pubmed]
  12. Effect of the carbamate insecticide Sevin on Anabaena sp. and Westiellopsis prolifica. Adhikary, S.P., Dash, P., Pattnaik, H. Acta Microbiol. Hung. (1984) [Pubmed]
  13. Effects of Sevin (carbaryl insecticide) on early life stages of zebrafish (Danio rerio). Todd, N.E., Van Leeuwen, M. Ecotoxicol. Environ. Saf. (2002) [Pubmed]
  14. Residues of carbaryl and two of its metabolites in eggs of laying hens treated with Sevin for northern fowl mite control by dipping. Ivey, M.C., Ivie, G.W., Devaney, J.A., Beerwinkle, K.R. Poult. Sci. (1984) [Pubmed]
  15. Toxic and sublethal effects of carbaryl on a freshwater catfish, Mystus vittatus (Bloch). Arunachalam, S., Jeyalakshmi, K., Aboobucker, S. Arch. Environ. Contam. Toxicol. (1980) [Pubmed]
  16. Simple radioactive assay for the estimation of DNA breaks. Sreekumaran Nair, R., Paulmurugan, R., Singh, A.J. Journal of applied toxicology : JAT. (2002) [Pubmed]
  17. Signaling by glutamate dehydrogenase in response to pesticide treatment and nitrogen fertilization of peanut (Arachis hypogaea L.). Osuji, G.O., Braithwaite, C. J. Agric. Food Chem. (1999) [Pubmed]
  18. Prognostic factors of early stage cervical cancer treated by radical hysterectomy. Sevin, B.U., Nadji, M., Lampe, B., Lu, Y., Hilsenbeck, S., Koechli, O.R., Averette, H.E. Cancer (1995) [Pubmed]
  19. The interaction of carbaryl with the metabolism of isolated hepatocytes: I. Effect on respiration and glycolysis. Parafita, M.A., Fernandez-Otero, P., Aldegunde, M.A. Gen. Pharmacol. (1984) [Pubmed]
  20. Methylcarbamate effects on Meckel's cartilages in the chick embryo. Virgintino, D., L'Abbate, N., Ribatti, D., Bertossi, M., Roncali, L., Ambrosi, L. Biological structures and morphogenesis. (1989) [Pubmed]
  21. Determination of carbofuran, carbaryl and their main metabolites in plasma samples of agricultural populations using gas chromatography-tandem mass spectrometry. Petropoulou, S.S., Tsarbopoulos, A., Siskos, P.A. Analytical and bioanalytical chemistry. (2006) [Pubmed]
  22. Effects of plant species, age and part on the disappearance of sevin, nuvacron and malathion residues. Rawash, I.A., Gaaboub, I.A., El-Gayar, F.M., El-Shazli, A.Y. Toxicology (1975) [Pubmed]
  23. Standard curves for nuvacron, malathion, sevin, DDT and kelthane tested against the mosquito Culex pipiens L. and the microcrustacean Daphnia magna Straus. Rawash, I.A., Gaaboub, I.A., El-Gayar, E.M., El-Shazli, A.Y. Toxicology (1975) [Pubmed]
  24. Effectiveness of Ectiban, egg oil, Rabon, or Sevin for control of northern fowl mites on laying hens. McKeen, W.D., Loomis, E.C., Dunning, L.L. Poult. Sci. (1983) [Pubmed]
  25. Effectiveness of bifenthrin (Onyx) and carbaryl (Sevin SL) for protecting individual, high-value conifers from bark beetle attack (Coleoptera: Curculionidae: Scolytinae) in the Western United States. Fettig, C.J., Allen, K.K., Borys, R.R., Christopherson, J., Dabney, C.P., Eager, T.J., Gibson, K.E., Hebertson, E.G., Long, D.F., Munson, A.S., Shea, P.J., Smith, S.L., Haverty, M.I. J. Econ. Entomol. (2006) [Pubmed]
  26. Simultaneous determination of 3-nitro tyrosine, o-, m-, and p-tyrosine in urine samples by liquid chromatography-ultraviolet absorbance detection with pre-column cloud point extraction. Du, M., Wu, W., Ercal, N., Ma, Y. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2004) [Pubmed]
  27. Effect of sevin on kinetic parameters of camel retina acetylcholinesterase. Kamal, M.A. Biochem. Mol. Biol. Int. (1997) [Pubmed]
  28. Metabolism of carbaryl (1-naphthyl N-methylcarbamate) in human embryonic lung cell cultures. Lin, T.H., North, H.H., Menzer, R.E. J. Agric. Food Chem. (1975) [Pubmed]
  29. Electron microscopic perspectives of gill pathology induced by 1-naphthyl-N-methylcarbamate in the goldfish (Carassius auratus Linnaeus). Pfeiffer, C.J., Qiu, B., Cho, C.H. Histol. Histopathol. (1997) [Pubmed]
  30. Thermal characteristics of lysine tri-isocyanate and its mixture with water. Li, X.R., Koseki, H., Iwata, Y. J. Hazard. Mater. (2007) [Pubmed]
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