Disease relevance of Argiopine

• The whole cell variant of the patch clamp technique was used to investigate the actions of the polyamine amide spider toxin, argiotoxin-636, on the excitability of cultured dorsal root ganglion neurones [1].

High impact information on Argiopine

• However, neither JSTx nor Argiotoxin 636 effectively blocked either parameter in cells differentiated into type II astrocytes [2].
• 1. The effect of the spider venom argiopine on L-glutamate-activated membrane channels of crayfish muscle was investigated using the patch-clamp technique [3].
• 4. Up to argiopine concentrations of 10(-7) M the kinetics of channel openings and of bursts measured in pre-block periods or during reversal of the block by hyperpolarization were indistinguishable from controls [3].
• The specificity of the response was tested with a glutamate receptor antagonist (argiotoxin 636) [4].
• Intracellular and extracellular application of argiotoxin-636 also decreased the number of action potentials evoked in response to 800-ms depolarizing current commands [1].

Biological context of Argiopine

• Argiotoxin-636 blocks excitatory synaptic transmission in rat hippocampal CA1 pyramidal neurons [5].
• A special type of argiopine-resistant, non-NMDA glutamate receptor is assumed to be involved in the generation of an EPSP by the monosynaptic DR input [6].
• PURPOSE: Twelve synthetic spider toxin analogs were prepared in an effort to better understand the structure-activity relationships of the polyamine portion of argiotoxin-636 (Arg-636), a noncompetitive NMDA receptor (NMDAR) antagonist [7].

Anatomical context of Argiopine

• Argiotoxin 636, (AR636), a synaptic antagonist from orb weaver spider venom, is shown to produce reversible blockade of excitatory transmission in CA1 pyramidal neurons of the in vitro rat hippocampus [5].
• The results suggest that argiopin selectively blocks only one population of the excitatory amino acid receptors on motoneurones, and these argiopin-sensitive receptors are found to be involved in sensorimotor synaptic transmission in the spinal cord [8].
• Inhibition of voltage-activated K+ currents in cultured sensory neurons by the polyamine spider toxin argiotoxin-636 may involve a polyamine transporter and an intracellular site of action [9].

Associations of Argiopine with other chemical compounds

• The effects of the arylalkyamine arthropod toxins argiotoxin 636 and philanthotoxin 343 were studied on N-methyl-D-aspartate receptor currents in cultured rat hippocampal neurons using whole-cell recording techniques [10].

Gene context of Argiopine

• In addition, argiotoxin 636 exerts a polyamine-like facilitation of N-methyl-D-aspartate receptor currents [10].

Analytical, diagnostic and therapeutic context of Argiopine

• The same concentrations of argiopin (7.5 x 10(-8) M to 2.3 x 10(-7) M) suppressed the responses of the ventral root to electrical stimulation of the dorsal root [8].

References