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Chemical Compound Review

Argiopin     (2S)-N-[5-[3-[3-[[(2S)-2- amino-5...

Synonyms: Argiopine, Argiotoxin-636, argiotoxin 636, CHEMBL1098240, CHEBI:724404, ...
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Disease relevance of Argiopine


High impact information on Argiopine


Biological context of Argiopine


Anatomical context of Argiopine

  • Argiotoxin 636, (AR636), a synaptic antagonist from orb weaver spider venom, is shown to produce reversible blockade of excitatory transmission in CA1 pyramidal neurons of the in vitro rat hippocampus [5].
  • The results suggest that argiopin selectively blocks only one population of the excitatory amino acid receptors on motoneurones, and these argiopin-sensitive receptors are found to be involved in sensorimotor synaptic transmission in the spinal cord [8].
  • Inhibition of voltage-activated K+ currents in cultured sensory neurons by the polyamine spider toxin argiotoxin-636 may involve a polyamine transporter and an intracellular site of action [9].

Associations of Argiopine with other chemical compounds


Gene context of Argiopine


Analytical, diagnostic and therapeutic context of Argiopine


  1. Extracellular or intracellular application of argiotoxin-636 has inhibitory actions on membrane excitability and voltage-activated currents in cultured rat sensory neurones. Scott, R.H., Thatcher, N.M., Ayar, A., Mitchell, S.J., Pollock, J., Gibson, M.T., Duce, I.R., Moya, E., Blagbrough, I.S. Neuropharmacology (1998) [Pubmed]
  2. Developmental regulation of the toxin sensitivity of Ca(2+)-permeable AMPA receptors in cortical glia. Meucci, O., Fatatis, A., Holzwarth, J.A., Miller, R.J. J. Neurosci. (1996) [Pubmed]
  3. Argiopine blocks glutamate-activated single-channel currents on crayfish muscle by two mechanisms. Antonov, S.M., Dudel, J., Franke, C., Hatt, H. J. Physiol. (Lond.) (1989) [Pubmed]
  4. Synaptic activity modifies the levels of Dorsal and Cactus at the neuromuscular junction of Drosophila. Bolatto, C., Chifflet, S., Megighian, A., Cantera, R. J. Neurobiol. (2003) [Pubmed]
  5. Argiotoxin-636 blocks excitatory synaptic transmission in rat hippocampal CA1 pyramidal neurons. Ashe, J.H., Cox, C.L., Adams, M.E. Brain Res. (1989) [Pubmed]
  6. Identification of two types of excitatory monosynaptic inputs in frog spinal motoneurones. Antonov, S.M., Kalinina, N.I., Kurchavyj, G.G., Magazanik, L.G., Shupliakov, O.V., Vesselkin, N.P. Neurosci. Lett. (1990) [Pubmed]
  7. Design, synthesis, and biological evaluation of spider toxin (argiotoxin-636) analogs as NMDA receptor antagonists. Moe, S.T., Smith, D.L., Chien, Y., Raszkiewicz, J.L., Artman, L.D., Mueller, A.L. Pharm. Res. (1998) [Pubmed]
  8. Argiopin blocks the glutamate responses and sensorimotor transmission in motoneurones of isolated frog spinal cord. Antonov, S.M., Grishin, E.V., Magazanik, L.G., Shupliakov, O.V., Vesselkin, N.P., Volkova, T.M. Neurosci. Lett. (1987) [Pubmed]
  9. Inhibition of voltage-activated K+ currents in cultured sensory neurons by the polyamine spider toxin argiotoxin-636 may involve a polyamine transporter and an intracellular site of action. Scott, R.H., Gibson, M.T. Biochem. Soc. Trans. (1998) [Pubmed]
  10. Multiple actions of arylalkylamine arthropod toxins on the N-methyl-D-aspartate receptor. Donevan, S.D., Rogawski, M.A. Neuroscience (1996) [Pubmed]
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