The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AG-H-00151     4-amino-1,6- dihydropyrimidine-2,5-dione

Synonyms: ANW-67254, AC1L2QGR, AC1Q6DBB, AK-89493, CTK5E1430, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of 5-Hydroxycytosine


High impact information on 5-Hydroxycytosine

  • Conversely, 5-hydroxycytosine was removed efficiently only by Ntg2 [4].
  • Another oxidative lesion, 5-hydroxycytosine, also enhanced top1 cleavage by 2-fold when incorporated at the +1 position of the scissile strand [5].
  • We also show a correlation between severely defective incision of TG and 5OHC and reduced levels of NTH1 in PC-3 mitochondria [6].
  • The results indicated that endonuclease III induced the release of 5-hydroxyhydantoin (1), 5-hydroxyuracil (2), cis-uracil 5,6-glycol (3), 5-hydroxycytosine (4), trans-uracil 5,6-glycol (5), and trans-1-carbamoyl-2-oxo-4,5-dihydroxyimidazolidine (8) [7].
  • The excision of 5-hydroxyuracil (2) and 5-hydroxycytosine (4) lesions was studied in greater detail by enzymatic digestion and HPLC coupled to electrochemical (EC) detection which determines the amounts of these products in DNA [7].

Biological context of 5-Hydroxycytosine

  • To further elucidate this effect, we have introduced mutations in the helix-hairpin-helix domain of hNTH1 (K212S, P211R, +G212, and DeltaP211), and measured the kinetics of 5-hydroxycytosine removal of the mutants relative to wild type [8].

Anatomical context of 5-Hydroxycytosine


Associations of 5-Hydroxycytosine with other chemical compounds


  1. Excision of 5,6-dihydroxy-5,6-dihydrothymine, 5,6-dihydrothymine, and 5-hydroxycytosine from defined sequence oligonucleotides by Escherichia coli endonuclease III and Fpg proteins: kinetic and mechanistic aspects. D'Ham, C., Romieu, A., Jaquinod, M., Gasparutto, D., Cadet, J. Biochemistry (1999) [Pubmed]
  2. A new nitrogen base 5-hydroxycytosine in phage N-17 DNA. Kchromov, I.S., Sorotchkina, V.V., Nigmatullin, T.G., Tikchonenko, T.I. FEBS Lett. (1980) [Pubmed]
  3. Genotoxicity of ribo- and deoxyribonucleosides of 8-hydroxyguanine, 5-hydroxycytosine, and 2-hydroxyadenine: induction of SCE in human lymphocytes and mutagenicity in Salmonella typhimurium TA 100. Arashidani, K., Iwamoto-Tanaka, N., Muraoka, M., Kasai, H. Mutat. Res. (1998) [Pubmed]
  4. The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast. Alseth, I., Eide, L., Pirovano, M., Rognes, T., Seeberg, E., Bjørås, M. Mol. Cell. Biol. (1999) [Pubmed]
  5. Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine. Pourquier, P., Ueng, L.M., Fertala, J., Wang, D., Park, H.J., Essigmann, J.M., Bjornsti, M.A., Pommier, Y. J. Biol. Chem. (1999) [Pubmed]
  6. Cellular repair of oxidatively induced DNA base lesions is defective in prostate cancer cell lines, PC-3 and DU-145. Trzeciak, A.R., Nyaga, S.G., Jaruga, P., Lohani, A., Dizdaroglu, M., Evans, M.K. Carcinogenesis (2004) [Pubmed]
  7. Excision of oxidative cytosine modifications from gamma-irradiated DNA by Escherichia coli endonuclease III and human whole-cell extracts. Wagner, J.R., Blount, B.C., Weinfeld, M. Anal. Biochem. (1996) [Pubmed]
  8. Human endonuclease III acts preferentially on DNA damage opposite guanine residues in DNA. Eide, L., Luna, L., Gustad, E.C., Henderson, P.T., Essigmann, J.M., Demple, B., Seeberg, E. Biochemistry (2001) [Pubmed]
  9. Repair of oxidative DNA base lesions induced by fluorescent light is defective in xeroderma pigmentosum group A cells. Lipinski, L.J., Hoehr, N., Mazur, S.J., Dianov, G.L., Sentürker, S., Dizdaroglu, M., Bohr, V.A. Nucleic Acids Res. (1999) [Pubmed]
  10. Spontaneous and osmium tetroxide-induced mutagenesis in an Escherichia coli strain deficient in both endonuclease III and endonuclease VIII. Najrana, T., Saito, Y., Uraki, F., Kubo, K., Yamamoto, K. Mutagenesis (2000) [Pubmed]
  11. The sequence context-dependent mispairing of 5-hydroxycytosine and 5-hydroxyuridine in vitro. Purmal, A.A., Lampman, G.W., Kow, Y.W., Wallace, S.S. Ann. N. Y. Acad. Sci. (1994) [Pubmed]
  12. Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase. Matsubara, M., Tanaka, T., Terato, H., Ohmae, E., Izumi, S., Katayanagi, K., Ide, H. Nucleic Acids Res. (2004) [Pubmed]
WikiGenes - Universities