Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Tyr-W-MIF-I (2S)-N-[(1S)-1- (aminocarbonylmethylcarbamo...

Synonyms: Tyr-W-mif-1, SureCN1373185, LS-173213, AC1L31C2, C27H32N6O5, ...

Harrison, L.M. et al., Gergen, K.A. et al., Zadina, J.E. et al., Harrison, L.M. et al., Hackler, L. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tyrosyl-prolyl-tryptophyl-glycinamide

Tyr-W-MIF-1 attenuates down-regulation of opiate receptors in SH-SY5Y human neuroblastoma cells [1].

High impact information on Tyrosyl-prolyl-tryptophyl-glycinamide

Family members MIF-1, Tyr-W-MIF-1 and Tyr-K-MIF-1 are also included [2].
Regional differences in the metabolism of Tyr-MIF-1 and Tyr-W-MIF-1 by rat brain mitochondria [3].
The possible role of endogenous opiate-modulating peptides in preventing such down-regulation was investigated by addition of Tyr-W-MIF-1 to an in vitro preparation, the human neuroblastoma cell line SH-SY5Y, in which down-regulation of opiate receptors has been demonstrated previously [1].
Differential effects of endomorphin-1, endomorphin-2, and Tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes [4].
In addition, we provide new results suggesting that Tyr-W-MIF-1 may act as an antiopiate at the cellular level by inhibiting basal G-protein activation, in contrast to the activation of G-proteins by opiate agonists [5].

Biological context of Tyrosyl-prolyl-tryptophyl-glycinamide

When coadministered with 3 microM morphine, Tyr-W-MIF-1 dose-dependently attenuated morphine-induced down-regulation of both mu and delta receptors [1].
In this study, we used immunocytochemical (ICC) detection of FOS proto-oncogene protein to map brain areas activated by an ICV injection of Tyr-W-MIF-1 (200 micrograms) [6].
Structure-activity relationships of analogs of the endogenous brain peptides Tyr-MIF-1 and Tyr-W-MIF-1 [7].

Anatomical context of Tyrosyl-prolyl-tryptophyl-glycinamide

The results show that, in addition to previously described opiate-like actions (binding to the mu-receptor and inhibition of electrically induced contractions of the guinea pig ileum), Tyr-W-MIF-1 is capable of inducing significant analgesia [8].
However, despite the known selectivity of Tyr-W-MIF-1 for mu receptors, FOS immunoreactivity was also induced in nuclei of the amygdala, hypothalamus, and thalamus, where concentrations of kappa receptors were high but those of mu and delta receptors were not detected [6].

Associations of Tyrosyl-prolyl-tryptophyl-glycinamide with other chemical compounds

Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2), Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2), and MIF-1 (Pro-Leu-Gly-NH2) are biologically active peptides previously isolated from brain tissue [9].

Analytical, diagnostic and therapeutic context of Tyrosyl-prolyl-tryptophyl-glycinamide

We investigated the effect of spinal administration of Tyr-W-MIF-1 on analgesia using the mouse tail-flick assay [10].

References

Tyr-W-MIF-1 attenuates down-regulation of opiate receptors in SH-SY5Y human neuroblastoma cells. Harrison, L.M., Kastin, A.J., Zadina, J.E. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
The Tyr-MIF-1 family of peptides. Reed, G.W., Olson, G.A., Olson, R.D. Neuroscience and biobehavioral reviews. (1994) [Pubmed]
Regional differences in the metabolism of Tyr-MIF-1 and Tyr-W-MIF-1 by rat brain mitochondria. Kastin, A.J., Hahn, K., Banks, W.A., Zadina, J.E. Biochem. Pharmacol. (1998) [Pubmed]
Differential effects of endomorphin-1, endomorphin-2, and Tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes. Harrison, L.M., Kastin, A.J., Zadina, J.E. Peptides (1998) [Pubmed]
Opiate tolerance and dependence: receptors, G-proteins, and antiopiates. Harrison, L.M., Kastin, A.J., Zadina, J.E. Peptides (1998) [Pubmed]
Expression of the FOS proto-oncogene protein in brain after ICV administration of Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2). Gergen, K.A., Chang, S.L., Niu, Y.F., Kastin, A.J., Zadina, J.E. Peptides (1994) [Pubmed]
Structure-activity relationships of analogs of the endogenous brain peptides Tyr-MIF-1 and Tyr-W-MIF-1. Erchegyi, J., Zadina, J.E., Qiu, X.D., Kersh, D.C., Ge, L.J., Brown, M.M., Kastin, A.J. Pept. Res. (1993) [Pubmed]
Prolonged analgesia after intracerebroventricular Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2). Zadina, J.E., Kastin, A.J., Kenigs, V., Bruno, C., Hackler, L. Neurosci. Lett. (1993) [Pubmed]
Isolation of a novel peptide with a unique binding profile from human brain cortex: Tyr-K-MIF-1 (Tyr-Pro-Lys-Gly-NH2). Hackler, L., Kastin, A.J., Zadina, J.E. Peptides (1994) [Pubmed]
Intrathecal Tyr-W-MIF-1 produces potent, naloxone-reversible analgesia modulated by alpha 2-adrenoceptors. Gergen, K.A., Zadina, J.E., Kastin, A.J., Paul, D. Eur. J. Pharmacol. (1996) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.