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Chemical Compound Review

SureCN26181     cyclohexanecarboxamide

Synonyms: CHEMBL366975, AG-D-31256, SureCN1714291, ACMC-20alcz, NSC-16584, ...
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Disease relevance of cyclohexanecarboxamide


High impact information on cyclohexanecarboxamide

  • A new series of nonpeptidic cathepsin K inhibitors that are based on a beta-substituted cyclohexanecarboxamide motif has been developed [2].
  • Inactivating RhoA by exoenzyme C3 (2 mug ml(-1)) or inhibiting Rho-kinase with (+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) cyclohexanecarboxamide dihydrochloride monohydrate (Y-27632; 10(-5) M) had no effect on the decrease of both tension and [Ca(2+)](cyt) generated by exogenous NO [3].
  • N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-nitrophenyl) cyclohexanecarboxamide: a novel pre- and postsynaptic 5-hydroxytryptamine(1A) receptor antagonist active on the lower urinary tract [4].
  • The possible antinociceptive effect of a Rho-kinase inhibitor, (+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) cyclohexanecarboxamide dihydrochloride monohydrate (Y-27632), was investigated in mice by using the hot-plate and abdominal constriction response (writhing) tests [5].
  • In contrast to EEDQ alone, agonist-stimulated [35S]GTPgammaS binding was not reduced in hippocampal membranes preincubated with EEDQ and the 5-HT(1A) receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl- cyclohexanecarboxamide maleate (WAY 100,635), suggesting that EEDQ acts directly on the receptor [6].

Anatomical context of cyclohexanecarboxamide

  • The 5-HT decreases in dorsal raphe and hippocampus produced by BMY-14802 were completely antagonized by pretreatment with 1.0 mg/kg of the specific 5-HT1A antagonist, WAY-100635 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride) [7].

Associations of cyclohexanecarboxamide with other chemical compounds


Gene context of cyclohexanecarboxamide


  1. Effect of IS-741 on cell adhesion between human umbilical vein endothelial cells and HL-60 cells. Shikama, H., Yotsuya, S., Satake, S., Sugi, H., Kato, M. Biol. Pharm. Bull. (1999) [Pubmed]
  2. Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K. Crane, S.N., Black, W.C., Palmer, J.T., Davis, D.E., Setti, E., Robichaud, J., Paquet, J., Oballa, R.M., Bayly, C.I., McKay, D.J., Somoza, J.R., Chauret, N., Seto, C., Scheigetz, J., Wesolowski, G., Massé, F., Desmarais, S., Ouellet, M. J. Med. Chem. (2006) [Pubmed]
  3. Nitric oxide relaxes circular smooth muscle of rat distal colon through RhoA/Rho-kinase independent Ca2+ desensitisation. Colpaert, E.E., Levent, A., Lefebvre, R.A. Br. J. Pharmacol. (2005) [Pubmed]
  4. N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-nitrophenyl) cyclohexanecarboxamide: a novel pre- and postsynaptic 5-hydroxytryptamine(1A) receptor antagonist active on the lower urinary tract. Leonardi, A., Guarneri, L., Poggesi, E., Angelico, P., Velasco, C., Cilia, A., Testa, R. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  5. Rho-kinase inhibitor, Y-27632, has an antinociceptive effect in mice. Büyükafşar, K., Yalçin, I., Kurt, A.H., Tiftik, R.N., Sahan-Firat, S., Aksu, F. Eur. J. Pharmacol. (2006) [Pubmed]
  6. Inactivation of 5-HT(1A) receptors in hippocampal and cortical homogenates. Alper, R.H., Nelson, D.L. Eur. J. Pharmacol. (2000) [Pubmed]
  7. 5-HT1A receptor agonist effects of BMY-14802 on serotonin release in dorsal raphe and hippocampus. Matos, F.F., Korpinen, C., Yocca, F.D. Eur. J. Pharmacol. (1996) [Pubmed]
  8. Antagonism of the 5-HT1A receptor stimulus in a conditioned taste aversion procedure. Berendsen, H.H., Broekkamp, C.L. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (1999) [Pubmed]
  9. Effects of the Rho-kinase inhibitors, Y-27632 and fasudil, on the corpus cavernosum from diabetic mice. Büyükafşar, K., Un, I. Eur. J. Pharmacol. (2003) [Pubmed]
  10. Discriminative stimulus properties of flesinoxan: effects of enantiomers, (S)-UH301 and WAY-100635. Gommans, J., Hijzen, T.H., Maes, R.A., Mos, J., Olivier, B. Eur. J. Pharmacol. (1995) [Pubmed]
  11. Characterization of 5-HT1A receptor-mediated [35S]GTPgammaS binding in rat hippocampal membranes. Alper, R.H., Nelson, D.L. Eur. J. Pharmacol. (1998) [Pubmed]
  12. Characterization of the radioactive metabolites of the 5-HT1A receptor radioligand, [O-methyl-11C]WAY-100635, in monkey and human plasma by HPLC: comparison of the behaviour of an identified radioactive metabolite with parent radioligand in monkey using PET. Osman, S., Lundkvist, C., Pike, V.W., Halldin, C., McCarron, J.A., Swahn, C.G., Ginovart, N., Luthra, S.K., Bench, C.J., Grasby, P.M., Wikström, H., Barf, T., Cliffe, I.A., Fletcher, A., Farde, L. Nucl. Med. Biol. (1996) [Pubmed]
  13. Characterisation of the appearance of radioactive metabolites in monkey and human plasma from the 5-HT1A receptor radioligand, [carbonyl-11C]WAY-100635--explanation of high signal contrast in PET and an aid to biomathematical modelling. Osman, S., Lundkvist, C., Pike, V.W., Halldin, C., McCarron, J.A., Swahn, C.G., Farde, L., Ginovart, N., Luthra, S.K., Gunn, R.N., Bench, C.J., Sargent, P.A., Grasby, P.M. Nucl. Med. Biol. (1998) [Pubmed]
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