Chemical Compound Review:
DOI-P 1-(4-iodo-2,5-dimethoxy- phenyl)propan-2-amine
Synonyms:
Racemic DOI, CHEMBL6616, SureCN293580, CHEBI:64629, QC-2023, ...
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- Modulation of 8-OH-DPAT-induced hypothermia by imipramine in rats. Kitamura, Y., Araki, H., Shibata, K., Gomita, Y., Tanizaki, Y. J. Pharmacol. Sci. (2003)
- A 5-hydroxytryptamine2 agonist augments gamma-aminobutyric acid and excitatory amino acid inputs to noradrenergic locus coeruleus neurons. Chiang, C., Aston-Jones, G. Neuroscience (1993)
- Decreased social behaviour following 3,4-methylenedioxymethamphetamine (MDMA) is accompanied by changes in 5-HT2A receptor responsivity. Bull, E.J., Hutson, P.H., Fone, K.C. Neuropharmacology (2004)
- Serotonin agonists increase transferrin levels via activation of 5-HT1C receptors in choroid plexus epithelium. Esterle, T.M., Sanders-Bush, E. J. Neurosci. (1992)
- Effects of antidepressants on intracellular Ca2+ mobilization in CHO cells transfected with the human 5-HT2C receptors. Akiyoshi, J., Isogawa, K., Yamada, K., Nagayama, H., Fujii, I. Biol. Psychiatry (1996)
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- 5HT1A serotonin receptor agonists inhibit Plasmodium falciparum by blocking a membrane channel. Locher, C.P., Ruben, P.C., Gut, J., Rosenthal, P.J. Antimicrob. Agents Chemother. (2003)
- Group II metabotropic glutamate receptor modulation of DOI-induced c-fos mRNA and excitatory responses in the cerebral cortex. Zhai, Y., George, C.A., Zhai, J., Nisenbaum, E.S., Johnson, M.P., Nisenbaum, L.K. Neuropsychopharmacology (2003)
- Evaluation of DOI, 8-OH-DPAT, eticlopride and amphetamine on impulsive responding in a reaction time task in rats. Blokland, A., Sik, A., Lieben, C. Behavioural pharmacology. (2005)
- Serotonin2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice. Yamada, J., Sugimoto, Y., Horisaka, K. Biol. Pharm. Bull. (1995)
- Lack of cross-tolerance for hypophagia induced by DOI versus m-CPP suggests separate mediation by 5-HT2A and 5-HT2C receptors, respectively. Aulakh, C.S., Mazzola-Pomietto, P., Hulihan-Giblin, B.A., Murphy, D.L. Neuropsychopharmacology (1995)
- Serotonin2/1C receptor activation causes a localized expression of the immediate-early gene c-fos in rat brain: evidence for involvement of dorsal raphe nucleus projection fibres. Leslie, R.A., Moorman, J.M., Coulson, A., Grahame-Smith, D.G. Neuroscience (1993)
- Mechanism of tolerance development to 2,5-dimethoxy-4-iodoamphetamine in rats: down-regulation of the 5-HT2A, but not 5-HT2C, receptor. Smith, R.L., Barrett, R.J., Sanders-Bush, E. Psychopharmacology (Berl.) (1999)
- The central action of the 5-HT2 receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on cardiac inotropy and vascular resistance in the anaesthetized cat. Ramage, A.G., Daly, M.B. Br. J. Pharmacol. (1998)
- Spinal 5-HT2 receptor-mediated facilitation of pudendal nerve reflexes in the anaesthetized cat. Danuser, H., Thor, K.B. Br. J. Pharmacol. (1996)
- P-chloroamphetamine induces c-fos in rat brain: a study of serotonin2A/2C receptor function. Moorman, J.M., Leslie, R.A. Neuroscience (1996)
- Adrenalectomy or metyrapone-pretreatment abolishes cerebral metabolic responses to the serotonin agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) in the hippocampus. Freo, U., Holloway, H.W., Kalogeras, K., Rapoport, S.I., Soncrant, T.T. Brain Res. (1992)
- Stimulation of 5-HT(2A/2C) receptors within specific hypothalamic nuclei differentially antagonizes NPY-induced feeding. Currie, P.J., Coscina, D.V. Neuroreport (1997)
- Stimulation of 5-HT2 receptors in the nucleus tractus solitarius enhances NMDA receptor-mediated reflex-evoked bradycardiac responses in the rat. N'Diaye, A., Sévoz-Couche, C., Nosjean, A., Hamon, M., Laguzzi, R. Autonomic neuroscience : basic & clinical. (2001)
- Release-regulating serotonin 5-HT1D autoreceptors in human cerebral cortex. Maura, G., Thellung, S., Andrioli, G.C., Ruelle, A., Raiteri, M. J. Neurochem. (1993)
- Characterisation of human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors expressed in the human neuroblastoma cell line SH-SY5Y: comparative stimulation by hallucinogenic drugs. Newton, R.A., Phipps, S.L., Flanigan, T.P., Newberry, N.R., Carey, J.E., Kumar, C., McDonald, B., Chen, C., Elliott, J.M. J. Neurochem. (1996)
- Modulation of respiratory activity of neonatal rat phrenic motoneurones by serotonin. Lindsay, A.D., Feldman, J.L. J. Physiol. (Lond.) (1993)
- Effects of serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibition plus 5-HT(2A) receptor antagonism on the firing activity of norepinephrine neurons. Szabo, S.T., Blier, P. J. Pharmacol. Exp. Ther. (2002)
- Stimulatory and inhibitory effects of serotonergic hallucinogens on spinal mono- and polysynaptic reflex pathways in the rat. Yamazaki, J., Ono, H., Nagao, T. Neuropharmacology (1992)
- Evidence for involvement of 5-HT1C and 5-HT2 receptors in the food intake suppressant effects of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI). Aulakh, C.S., Hill, J.L., Yoney, H.T., Murphy, D.L. Psychopharmacology (Berl.) (1992)
- Paradoxical effects of lithium on serotonergic receptor function: an immunocytochemical, behavioural and autoradiographic study. Moorman, J.M., Leslie, R.A. Neuropharmacology (1998)
- Different functions of spinal 5-HT1A and 5-HT2 receptor subtypes in modulating behaviour induced by excitatory amino acid receptor agonists in mice. Mjellem, N., Lund, A., Hole, K. Brain Res. (1993)
- Clozapine blocks dopamine, 5-HT2 and 5-HT3 responses in the medial prefrontal cortex: an in vivo microiontophoretic study. Gobbi, G., Janiri, L. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (1999)
- Effects of chlorisondamine and restraint on cortical [3H]ketanserin binding, 5-HT2A receptor-mediated head shakes, and behaviours in models of anxiety. Chaouloff, F., Baudrie, V., Coupry, I. Neuropharmacology (1994)
- Acute immobilization stress reduces (+/-)DOI-induced 5-HT2A receptor-mediated head shakes in rats. Yamada, S., Watanabe, A., Nankai, M., Toru, M. Psychopharmacology (Berl.) (1995)
- The influence of corticosterone on serotonergic stereotypy and sexual behavior in the female rat. Hanson, L.A., Gorzalka, B.B. Behav. Brain Res. (1999)
- Autoradiographic localization of 5HT2 receptors in rat brain using [125I]-DOI, a selective psychotomimetic radioligand. Nazarali, A.J., McKenna, D.J., Saavedra, J.M. Prog. Neuropsychopharmacol. Biol. Psychiatry (1989)