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Chemical Compound Review

Scyliorhinin I     (3S)-3-[[(1S)-5-amino-1- [[(1S)-1-[[(1S)-1...

Synonyms: AC1L3UDT, 103425-21-4, Ala-lys-phe-asp-lys-phe-tyr-gly-leu-met-NH2
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High impact information on Scyliorhinin I


Anatomical context of Scyliorhinin I


Associations of Scyliorhinin I with other chemical compounds

  • One peptide was identical to scyliorhinin I, previously identified in dogfish intestine, and the second was the undecapeptide Lys-Pro-Arg-Pro-Gly-Gln-Phe-Phe-Gly-Leu-Met-CONH2 which is structurally similar to mammalian substance P [5].

Gene context of Scyliorhinin I


Analytical, diagnostic and therapeutic context of Scyliorhinin I


  1. Membrane-Induced Structure of Scyliorhinin I: A Dual NK1/NK2 Agonist. Dike, A., Cowsik, S.M. Biophys. J. (2005) [Pubmed]
  2. Tachykinins with unusual structural features from a urodele, the amphiuma, an elasmobranch, the hammerhead shark, and an agnathan, the river lamprey. Waugh, D., Bondareva, V., Rusakov, Y., Bjenning, C., Nielsen, P.F., Conlon, J.M. Peptides (1995) [Pubmed]
  3. Scyliorhinin-I and -II induce reciprocal hindlimb scratching in mice: differentiation of spinal and supraspinal neurokinin receptors in vivo. Raffa, R.B., Martinez, R.P., Connelly, C.D. Neurosci. Lett. (1993) [Pubmed]
  4. Effect of scyliorhinin I and synthetic scyliorhinin I derivatives at mammalian tachykinin NK1, NK2 and NK3 receptors. Patacchini, R., Quartara, L., Rolka, K., Zboinska, J., Kupryszewski, G., Maggi, C.A. Eur. J. Pharmacol. (1993) [Pubmed]
  5. Primary structures and biological activities of substance-P-related peptides from the brain of the dogfish, Scyliorhinus canicula. Waugh, D., Wang, Y., Hazon, N., Balment, R.J., Conlon, J.M. Eur. J. Biochem. (1993) [Pubmed]
  6. The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors. Buck, S.H., Krstenansky, J.L. Eur. J. Pharmacol. (1987) [Pubmed]
  7. Neuropeptide K, scyliorhinin I and II: new tools in the tachykinin receptor field. Beaujouan, J.C., Saffroy, M., Petitet, F., Torrens, Y., Glowinski, J. Eur. J. Pharmacol. (1988) [Pubmed]
  8. Synthesis and biological activity in the GPI test of scyliorhinin I and its Val7 and Ile7 analogs. Rolka, K., Kupryszewski, G., Janas, P., Myszor, J., Herman, Z.S. Polish journal of pharmacology and pharmacy. (1992) [Pubmed]
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