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Chemical Compound Review:

Darvon [(2S,3R)-4-dimethylamino-3- methyl-1,2...

Synonyms: Algaphan, Depronal, Dolotard, Doloxene, Doraphen, ...

This record was replaced with 10100.

Andersen, L.S. et al., Tashjian, E.A. et al., Rappolt, R.T. et al., Licata, A.A. et al., Spirtes, M.A., et al.

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Disease relevance of propoxyphene

Spironolactone-induced gynaecomastia related to allergic reaction to "Darvon compound" [1].
The manic-depressive patient involved died of acute alcoholic and darvon toxicity [2].
This was due to optic neuritis from acute Darvon overdose [3].
Catastrophic neurologic signs due to drug interaction: Tegretol and Darvon [4].
The value of propoxyphene hydrochloride (Darvon) for the treatment of hyperhidrosis in the spinal cord injured patient: an anecdotal experience and case reports [5].

Psychiatry related information on propoxyphene

Outpatient detoxification of heroin addiction, 1969--1973 (methadone, darvon, codeine, clonidine) [6].

High impact information on propoxyphene

Twenty-five patients with spinal cord injury (SCI) were included in a double-blind, randomized, placebo-controlled, crossover trial using dextropropoxyphene hydrochloride (DP) in a slow release form (Abalgin Retard 150 mg Benzon Pharma A/S, Copenhagen) twice a day, for the treatment of annoying HH [7].

References

Spironolactone-induced gynaecomastia related to allergic reaction to "Darvon compound". Licata, A.A., Bartter, F.C. Lancet (1976) [Pubmed]
Lithium levels in monkey and human brain after chronic, therapeutic, oral dosage. Spirtes, M.A. Pharmacol. Biochem. Behav. (1976) [Pubmed]
Optic atrophy after propoxyphene overdose: report of a case. Weiss, I.S. Annals of ophthalmology. (1982) [Pubmed]
Catastrophic neurologic signs due to drug interaction: Tegretol and Darvon. Oles, K.S., Mirza, W., Penry, J.K. Surgical neurology. (1989) [Pubmed]
The value of propoxyphene hydrochloride (Darvon) for the treatment of hyperhidrosis in the spinal cord injured patient: an anecdotal experience and case reports. Tashjian, E.A., Richter, K.J. Paraplegia. (1985) [Pubmed]
Outpatient detoxification of heroin addiction, 1969--1973 (methadone, darvon, codeine, clonidine). Rappolt, R.T., Lawrence, F. Clin. Toxicol. (1979) [Pubmed]
The prevalence of hyperhidrosis in patients with spinal cord injuries and an evaluation of the effect of dextropropoxyphene hydrochloride in therapy. Andersen, L.S., Biering-Sørensen, F., Müller, P.G., Jensen, I.L., Aggerbeck, B. Paraplegia. (1992) [Pubmed]

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