Disease relevance of Maleic acid hydrazide

• Effects of maleic acid hydrazide (MH) and X-ray treatment were analysed in chromosomal aberration, sister chromatid exchange (SCE) and TUNEL tests [1].
• There were more epileptic seizures on Tegretol Retard than on Neurotol slow, but the difference was not statistically significant [2].
• Eleven healthy subjects and 8 patients with Type 1 diabetes mellitus were made hypoglycaemic by 60 min insulin infusion (40 mU m(-2)) after 2 weeks' oral therapy with Euphyllin Retard (theophylline) or placebo [3].
• Once-daily diltiazem extended-release 240 mg (Lacerol-HTA Retard) was evaluated for safety, efficacy, and trough-to-peak ratio in a multicenter open study by using 24-h blood pressure (BP) monitoring in mild-to-moderate essential hypertension [4].
• The power of the combination of detailed behavioral, neuroanatomical, and genetic studies has been demonstrated in studies of other conditions involving the sex chromosomes, such as Fragile X syndrome (Mazzocco [2000] Ment Retard Develop Disabil Res Rev. 6:96-106) and Turner syndrome (Ross [2000] Ment Retard Develop Disabil Res Rev. 6:135-141) [5].

Psychiatry related information on Maleic acid hydrazide

• Being an extension of a previous study [Am. J. Mental Retard. 106 (2001) 209], the significant decrease of the mean number of toileting accidents in function of initiating the procedure offers a further contribution to the validity of response restriction as a method for toilet training [6].

High impact information on Maleic acid hydrazide

• After baseline evaluation, consisting of an exercise test and a questionnaire investigating patients' anginal symptoms, the patients were randomly allocated to double-blind treatment for 6 weeks with either metoprolol (Controlled Release, 200 mg once daily) or nifedipine (Retard, 20 mg twice daily) according to a parallel group design [7].
• Higher efficiency was also demonstrated when the MCN frequencies were scored from the F1 cells in both Allium and Vicia treated with formaldehyde (FA), mitomycin C (MMC), and maleic hydrazide (MH) [8].
• For the Vicia faba assay, all laboratories reported a positive response for MNU, AG, and MH, whereas two of the six laboratories reported a negative response for NaN3 [9].
• Bunazosin Retard was associated with increases in GFR and ERPF in both normal and renally impaired groups; the increases were statistically significant in the renally impaired group (n = 14) [10].
• MH treatment resulted in aberration yields comparable to those observed in Vicia faba, MMC and TEM were less efficient aberration inducers in P. abies [11].

Chemical compound and disease context of Maleic acid hydrazide

• Four coded chemicals, azidoglycerol (AG), N-methyl-N-nitrosourea (MNU), sodium azide (NaN3) and maleic hydrazide (MH) were tested with the Vicia faba chromosomal aberration assay [12].
• The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients [13].
• CONCLUSIONS: Both felodipine ER and nifedipine Retard are effective "add-on' drugs in patients with monotherapy-resistant hypertension [14].

Biological context of Maleic acid hydrazide

• The mean bioavailability of CBZ from Neurotol slow was 11% (P = 0.002) higher than from Tegretol Retard. Owing to the better bioavailability, the peak (Cmax), lowest (Cmin) and mean (Css) concentrations of CBZ were also significantly higher during Neurotol slow treatment [2].
• Variation of the time span between heat shock (hs) and clastogen treatment of V. faba root tip meristems showed that hs protection is a very quick response (effective after less than 10 min) and lasting for up to 240 min in the case of induction of chromatid aberrations by maleic hydrazide (MH) [15].
• Effect of Bellergal Retard on climacteric complaints: a double-blind, placebo-controlled study [16].
• 6. At pH 7.6, MH at 1 x 10(-3)M without S-9 mix inhibited cell multiplication, but did not cause a significant increase of SCEs per cell [17].

Anatomical context of Maleic acid hydrazide

• Addition of insulin and dbcAMP was required to maintain 3 beta-HSD activity in cells cultured for more than 3 days [18].
• The olfactory bulb (OB), anterior olfactory nucleus (AON) and prepyriform cortex (PC) maintain 3 kinds of feedback among their populations of excitatory and inhibitory neurons: negative feedback, mutual excitation, and mutual inhibition [19].
• The clinical characteristics of highly purified porcine NPH-insulin (Insulin Retard RI) were investigated, including absorption from the subcutaneous tissue, blood glucose-lowering effect, stability of mixtures of NPH and regular insulin and measurement of circulating porcine proinsulin and insulin antibodies in diabetes [20].
• The results showed higher sensitivity of the nuclei of leukocytes as compared to the nuclei of plant cells to mutagenic treatment with the applied doses of MH and MNU [21].
• Metabolism of maleic hydrazide (MH) by hepatic microsomes from phenobarbital induced rats [22].

Associations of Maleic acid hydrazide with other chemical compounds

• Effects of novobiocin on heat shock protection against chromatid aberration induction by triethylenemelamine (TEM) and maleic hydrazide (MH) in Vicia faba [23].
• Effects of benzamide pretreatment on clastogenic adaptation of Vicia faba root-tip meristem cells to triethylenemelamine (TEM) and maleic hydrazide (MH) [24].
• Assessment of these simulations suggests that blood pressure control with nifedipine Retard is significantly improved by three times daily drug administration [25].
• The relative bioavailability of the two formulations were 59.01 and 47.96%, respectively, relative to that of the commercial Voltaren Retard tablets of Ciba-Geigy which showed a Kel of 0.044 h-1 corresponding to a t1/2 of 15.75 h and MRT of 7.45 +/- 1.10 h [26].
• Between Theograd, Theolair (Nuelin) Retard, and Theolin (Theodur) Retard no statistically significant difference in absolute bioavailability was observed, and virtually no side effects were reported [27].

Gene context of Maleic acid hydrazide

• One humic acid (HA) and two fulvic acids (FAs) of aquatic origin have been tested for their capacity to inhibit clastogenic events caused by maleic hydrazide (MH) in germinating seeds of the herbaceous plant species Allium cepa and Vicia faba [28].

Analytical, diagnostic and therapeutic context of Maleic acid hydrazide

• The relative efficacy of two twice-daily insulin regimens using highly purified insulins, once daily Ultratard with twice daily Actrapid (ultralente/soluble) and twice daily Actrapid with twice daily Retard (soluble/isophane), has been studied in 12 diabetics in a cross-over study [29].
• The evaluation of genotoxic activity was made by counting micronuclei (MN) and aberrant anatelophases (AT) in root tip cells after treatment with HA or FA alone, MH alone, and interacted HA + MH and FA + MH [28].
• The purpose of this study was to evaluate the differences in serum theophylline concentration (STC) caused by morning or evening dosing of Euphyllin Retard, a brand of SRT, for a period of 36 hours following oral administration [30].
• Allergy evaluation revealed intense positive responses to intradermal tests with bezafibrate active component and Eulitop Retard (skin tests in control subjects were negative) [31].
• A multicentre study of diclofenac sodium slow-release (Voltaren Retard) in the treatment of rheumatic disorders in the Kingdom of Saudi Arabia [32].

References