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Chemical Compound Review:

Polybrominated biphenyls 1,2,3-tribromo-5-(2,3,4...

Synonyms: PBB's, CCRIS 3078, AG-H-36812, LS-7665, AC1L4KAU, ...

Dharma, D.N. et al., Safe, S., Silberhorn, E.M. et al., Kang, K.S. et al., Kreiss, K. et al., et al.

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Disease relevance of Polybrominated biphenyls

The acute toxicity of PBB in laboratory animals is low, but a variety of subacute effects have been reported [1].
Birth weights of calves from dams exposed to 250 mg PBB/head/day were significantly greater than calves of dams exposed to 0 mg or 0.25 mg/head/day [2].
Some epidemiological studies have claimed an association between metabolites of 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT), polychlorinated biphenyls (PCBs), and polybrominated biphenyls (PBBs) and breast cancer, but others have reported no such association [3].

High impact information on Polybrominated biphenyls

A cross section of the population of Michigan was studied in 1978 to evaluate residual burdens of polybrominated biphenyls (PBBs), a flame-retardant chemical that had contaminated the state's food supply five years earlier [4].
The epidemiology of PCB and PBB exposure is reported along with an estimation of the risk of cancer to humans [5].
Long-term exposure to PCBs and PBBs in animals has been associated with the induction of neoplastic nodules in the liver and in some cases hepatocellular carcinoma [5].
Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action [6].
Women whose menopause occurred before their PBB exposure were excluded [7].

Chemical compound and disease context of Polybrominated biphenyls

Toxicity of polybrominated biphenyls (PBBs) in Domestic and laboratory animals [8].

Biological context of Polybrominated biphenyls

The decreased immune function detected among the PBB-exposed farm residents tended to affect families as a unit and was independent of exposed individuals' age or sex, speaking against the possibility of genetic predisposition [9].
Tissue distribution and elimination kinetics of polybrominated biphenyls (PBB) from rat tissue [10].
PBB body burdens were determined at d 14 and expressed on a log-log basis by Y = 0.91X + 2.179 (r2 = 0.974), where X = log of PBB concentration in diet (ppm) and Y = log of PBB body burden (micrograms) [11].

Anatomical context of Polybrominated biphenyls

Method for extraction, isolation, and detection of free polybrominated biphenyls (PBBs) from plasma, feces, milk, and bile using disposable glassware [12].
Hepatocytes were enlarged and vacuolated and lymphoid cells of the bursa of Fabricius were depleted by 10 ppm 2,3',4,4',5,5'-HBB, ppm 2,2',4,4',5,5'-HBB, and 10 or 100 ppm PBB [13].

Gene context of Polybrominated biphenyls

The geometric mean serum polychlorinated biphenyl (PCB) level (6.3 microgram/L) exceeded that of PBB (4.1 micrograms/L), although the range of PCB levels (smaller than 1-57 microgram/L) was narrower than that of PBB levels (smaller than 1-3150 micrograms/L) [14].
Pathologic effects of 2,2',4,4',5,5'-hexabromobiphenyl (HBB), 2,3',4,4',5,5'-HBB, and a commercial mixture of polybrominated biphenyls (PBB) were compared in White leghorn cockerels [13].

Analytical, diagnostic and therapeutic context of Polybrominated biphenyls

A complete evaluation of the human consequences of exposure to PBB await the conclusion of long-term epidemiological studies [1].

References

The PBB episode in Michigan: an overall appraisal. Fries, G.F. Crit. Rev. Toxicol. (1985) [Pubmed]
Effects of PBBs on cattle. I. Clinical evaluations and clinical chemistry. Durst, H.I., Willett, L.B., Schanbacher, F.L., Moorhead, P.D. Environ. Health Perspect. (1978) [Pubmed]
Inhibition of gap junctional intercellular communication in normal human breast epithelial cells after treatment with pesticides, PCBs, and PBBs, alone or in mixtures. Kang, K.S., Wilson, M.R., Hayashi, T., Chang, C.C., Trosko, J.E. Environ. Health Perspect. (1996) [Pubmed]
Human tissue burdens of halogenated aromatic chemicals in Michigan. Wolff, M.S., Anderson, H.A., Selikoff, I.J. JAMA (1982) [Pubmed]
Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs. Silberhorn, E.M., Glauert, H.P., Robertson, L.W. Crit. Rev. Toxicol. (1990) [Pubmed]
Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action. Safe, S. Crit. Rev. Toxicol. (1984) [Pubmed]
Time to menopause in relation to PBBs, PCBs, and smoking. Blanck, H.M., Marcus, M., Tolbert, P.E., Schuch, C., Rubin, C., Henderson, A.K., Zhang, R.H., Hertzberg, V.S. Maturitas. (2004) [Pubmed]
Toxicity of polybrominated biphenyls (PBBs) in Domestic and laboratory animals. Damstra, T., Jurgelski, W., Posner, H.S., Vouk, V.B., Bernheim, N.J., Guthrie, J., Luster, M., Falk, H.L. Environ. Health Perspect. (1982) [Pubmed]
Immunologic dysfunction among PBB-exposed Michigan dairy farmers. Bekesi, J.G., Anderson, H.A., Roboz, J.P., Roboz, J., Fischbein, A., Selikoff, I.J., Holland, J.F. Ann. N. Y. Acad. Sci. (1979) [Pubmed]
Tissue distribution and elimination kinetics of polybrominated biphenyls (PBB) from rat tissue. Miceli, J.N., Marks, B.H. Toxicol. Lett. (1981) [Pubmed]
Elimination of PBBs in rats. Effect of mineral oil and/or feed restriction. Polin, D., Bursian, S.J., Underwood, M.S., Wiggers, P.A., Biondo, N., Su, I., Braselton, W.E., Render, J.A. Journal of toxicology and environmental health. (1991) [Pubmed]
Method for extraction, isolation, and detection of free polybrominated biphenyls (PBBs) from plasma, feces, milk, and bile using disposable glassware. Willett, L.B., Brumm, C.J., Williams, C.L. J. Agric. Food Chem. (1978) [Pubmed]
Pathologic effects of 2,2',4,4',5,5'-and 2,3',4,4',5,5'-hexabromobiphenyl in white leghorn cockerels. Dharma, D.N., Sleight, S.D., Ringer, R.K., Aust, S.D. Avian Dis. (1982) [Pubmed]
Serial PBB levels, PCB levels, and clinical chemistries in Michigan's PBB cohort. Kreiss, K., Roberts, C., Humphrey, H.E. Arch. Environ. Health (1982) [Pubmed]

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