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Chemical Compound Review

Polybrominated biphenyls     1,2,3-tribromo-5-(2,3,4...

Synonyms: PBB's, CCRIS 3078, AG-H-36812, LS-7665, AC1L4KAU, ...
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Disease relevance of Polybrominated biphenyls


High impact information on Polybrominated biphenyls


Chemical compound and disease context of Polybrominated biphenyls


Biological context of Polybrominated biphenyls


Anatomical context of Polybrominated biphenyls


Gene context of Polybrominated biphenyls

  • The geometric mean serum polychlorinated biphenyl (PCB) level (6.3 microgram/L) exceeded that of PBB (4.1 micrograms/L), although the range of PCB levels (smaller than 1-57 microgram/L) was narrower than that of PBB levels (smaller than 1-3150 micrograms/L) [14].
  • Pathologic effects of 2,2',4,4',5,5'-hexabromobiphenyl (HBB), 2,3',4,4',5,5'-HBB, and a commercial mixture of polybrominated biphenyls (PBB) were compared in White leghorn cockerels [13].

Analytical, diagnostic and therapeutic context of Polybrominated biphenyls


  1. The PBB episode in Michigan: an overall appraisal. Fries, G.F. Crit. Rev. Toxicol. (1985) [Pubmed]
  2. Effects of PBBs on cattle. I. Clinical evaluations and clinical chemistry. Durst, H.I., Willett, L.B., Schanbacher, F.L., Moorhead, P.D. Environ. Health Perspect. (1978) [Pubmed]
  3. Inhibition of gap junctional intercellular communication in normal human breast epithelial cells after treatment with pesticides, PCBs, and PBBs, alone or in mixtures. Kang, K.S., Wilson, M.R., Hayashi, T., Chang, C.C., Trosko, J.E. Environ. Health Perspect. (1996) [Pubmed]
  4. Human tissue burdens of halogenated aromatic chemicals in Michigan. Wolff, M.S., Anderson, H.A., Selikoff, I.J. JAMA (1982) [Pubmed]
  5. Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs. Silberhorn, E.M., Glauert, H.P., Robertson, L.W. Crit. Rev. Toxicol. (1990) [Pubmed]
  6. Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): biochemistry, toxicology, and mechanism of action. Safe, S. Crit. Rev. Toxicol. (1984) [Pubmed]
  7. Time to menopause in relation to PBBs, PCBs, and smoking. Blanck, H.M., Marcus, M., Tolbert, P.E., Schuch, C., Rubin, C., Henderson, A.K., Zhang, R.H., Hertzberg, V.S. Maturitas. (2004) [Pubmed]
  8. Toxicity of polybrominated biphenyls (PBBs) in Domestic and laboratory animals. Damstra, T., Jurgelski, W., Posner, H.S., Vouk, V.B., Bernheim, N.J., Guthrie, J., Luster, M., Falk, H.L. Environ. Health Perspect. (1982) [Pubmed]
  9. Immunologic dysfunction among PBB-exposed Michigan dairy farmers. Bekesi, J.G., Anderson, H.A., Roboz, J.P., Roboz, J., Fischbein, A., Selikoff, I.J., Holland, J.F. Ann. N. Y. Acad. Sci. (1979) [Pubmed]
  10. Tissue distribution and elimination kinetics of polybrominated biphenyls (PBB) from rat tissue. Miceli, J.N., Marks, B.H. Toxicol. Lett. (1981) [Pubmed]
  11. Elimination of PBBs in rats. Effect of mineral oil and/or feed restriction. Polin, D., Bursian, S.J., Underwood, M.S., Wiggers, P.A., Biondo, N., Su, I., Braselton, W.E., Render, J.A. Journal of toxicology and environmental health. (1991) [Pubmed]
  12. Method for extraction, isolation, and detection of free polybrominated biphenyls (PBBs) from plasma, feces, milk, and bile using disposable glassware. Willett, L.B., Brumm, C.J., Williams, C.L. J. Agric. Food Chem. (1978) [Pubmed]
  13. Pathologic effects of 2,2',4,4',5,5'-and 2,3',4,4',5,5'-hexabromobiphenyl in white leghorn cockerels. Dharma, D.N., Sleight, S.D., Ringer, R.K., Aust, S.D. Avian Dis. (1982) [Pubmed]
  14. Serial PBB levels, PCB levels, and clinical chemistries in Michigan's PBB cohort. Kreiss, K., Roberts, C., Humphrey, H.E. Arch. Environ. Health (1982) [Pubmed]
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