Disease relevance of Polybrominated biphenyls

• Hypothyroidism in workers exposed to polybrominated biphenyls [1].
• Polychlorinated and polybrominated biphenyls are industrial chemical mixtures which have been implicated in numerous human poisonings in Taiwan and Japan (PCBs) and Michigan (PBBs) [2].
• Female Sprague Dawley rats were fed polybrominated biphenyls (PBB) for six months after a 70% partial hepatectomy and diethylnitrosamine administration (10 mg/kg body weight) to determine if PBB could serve as a tumor promoter in a two stage hepatocarcinogenesis test system [3].
• Behavioral and neurological toxicity of polybrominated biphenyls in rats and mice [4].
• Breast cancer among women exposed to polybrominated biphenyls [5].

High impact information on Polybrominated biphenyls

• Lymphocyte function of Michigan dairy farmers exposed to polybrominated biphenyls [6].
• Breast-milk monitoring to measure Michigan's contamination with polybrominated biphenyls [7].
• In 1973 and 1974, several thousand Michigan dairy farms were contaminated by polybrominated biphenyls (P.B.B.) as the result of an industrial accident [7].
• The calculated apparent half-life for decabromodiphenyl ether (BDE-209) was 15 days (95% confidence interval, 11-18 days) [8].
• Polybrominated biphenyls, polychlorinated biphenyls, body weight, and incidence of adult-onset diabetes mellitus [9].

Chemical compound and disease context of Polybrominated biphenyls

• Commercial mixtures of polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs) can cause hepatocellular carcinoma in rats and mice [10].
• Toxicity and residue studies in dairy animals with firemaster FF-1 (polybrominated biphenyls) [11].
• In a preliminary study, 12 male and 12 female weanling Sherman strain rats were given a single dose of 1000 mg polybrominated biphenyls (PBBs) FireMaster FF1 Lot 7042 kg/body weight as a 5% solution in corn oil [12].
• 1. Two [(14)C]-labelled brominated diphenyl ethers, 2,2',4,4',5-pentabromodiphenyl ether (BDE-99) and decabromodiphenyl ether (BDE-209), were separately administered to the male Sprague-Dawley rat as a single oral dose (2.2 mg kg(-1) body weight and 3.0 mg kg(-1), respectively) [13].

Biological context of Polybrominated biphenyls

• Toxicology of octabromobiphenyl and decabromodiphenyl oxide [14].
• Accidental contamination of the Michigan food chain with polybrominated biphenyls (PBBs) led to the exposure of more than 4,000 individuals in 1973 [15].
• The absorption, distribution, biotransformation and elimination of these polybrominated biphenyls are discussed along with the interactions with other chemicals and drugs [16].
• The results show that decabromodiphenyl ether is bioavailable and that occupational exposure to PBDEs occurs at the electronics-dismantling plant [17].
• A field biochemical epidemiology study was conducted using the Michigan cohort consisting of 51 rural residents exposed to polybrominated biphenyls (PBB) [18].

Anatomical context of Polybrominated biphenyls

• The metabolism of polybrominated biphenyls (PBBs) was studied in vitro by using rat liver microsomes in the presence of NADPH and atmospheric O2 [19].
• Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, kepone, and polybrominated biphenyls on transport systems in isolated rat hepatocytes [20].
• Altered metabolism of progesterone by hepatic microsomes from rats following dietary exposure to polybrominated biphenyls [21].
• Polybrominated biphenyls were detectable in bile and feces demonstrating transfer into the intestinal tract [22].
• Identification of polybrominated biphenyls in the adipose tissues of the general population of the United States [23].

Associations of Polybrominated biphenyls with other chemical compounds

• Absence of plant uptake and translocation of polybrominated biphenyls (PBBs) [24].
• Gas chromatography with an electron-capture detector was used to identify the major components of the polybrominated biphenyls (PBB's) in Firemaster FF-1 [25].
• Two unusual BFRs, 1,2-bis(2,4,6-tribromophenoxy)ethane and decabromodiphenyl ethane, were also detected in tree bark samples collected in Arkansas, suggesting the two manufacturing facilities are the sources of these compounds as well [26].
• Failure to induce mutations in Chinese hamster V79 cells and WB rat liver cells by the polybrominated biphenyls, Firemaster BP-6, 2,2',4,4',5,5'-hexabromobiphenyl, 3,3',4,4',5,5'-hexabromobiphenyl, and 3,3',4,4'-tetrabromobiphenyl [27].
• The separation of the 125 BDE congeners from five hydroxy- and two methoxy-BDEs and nine other brominated flame retardants (polybrominated biphenyls, tetrabromobisphenol-A, methyl-tetrabromobisphenol-A and hexabromocyclododecane) was also studied [28].

Gene context of Polybrominated biphenyls

• Determinants of polychlorinated biphenyls (PCBs), polybrominated biphenyls (PBBs), and dichlorodiphenyl trichloroethane (DDT) levels in the sera of young children [29].
• Spatial distribution of polybrominated diphenyl ethers and polybrominated biphenyls in lake trout from the Laurentian Great Lakes [30].
• Liver and mammary arylhydrocarbon hydroxylase and epoxide hydratase in lactating rats fed polybrominated biphenyls [31].
• 2,3,7,8-TCDD has been demonstrated to be the most potent and the most biologically active congener among the halogenated aromatic hydrocarbons (HAH), which include polychlorinated and polybrominated biphenyls (PCB and PBB, respectively) and the polychlorinated dibenzofurans (PCDF), in addition to the PCDD [32].
• A historical prospective mortality study was conducted on 3579 white male workers employed between 1935 and 1976 with potential exposures to brominated compounds including 1,2-dibromo-3-chloropropane (DBCP), Tris (2,3-dibromopropyl) phosphate, polybrominated biphenyls (PBB), various organic and inorganic bromides, and DDT [33].

Analytical, diagnostic and therapeutic context of Polybrominated biphenyls

• Development of a solid-phase microextraction gas chromatography/tandem mass spectrometry method for polybrominated diphenyl ethers and polybrominated biphenyls in water samples [34].
• During the development of a method to determine polybrominated diphenyl ethers (PBDEs) using GC/MS-MS equipped with a programmed temperature vaporizer (PTV) injector, a dramatic decrease in sensitivity to decabromodiphenyl ether (BDE-209) occurred and lack of sensitivity and repeatability was observed [35].
• Cohort study of Michigan residents exposed to polybrominated biphenyls: epidemiologic and immunologic findings [36].
• Spray-drying reduced the polybrominated biphenyls in whole milk and skim milk while pasteurization, freeze-drying, aging of cheese, and condensation were not effective [37].
• The usefulness of the proposed tests is demonstrated by applying them to data from a National Toxicology Program bioassay of decabromodiphenyl oxide [38].

References