High impact information on Flobufen

• Pharmacokinetics of flobufen and its main active metabolite in the rat [1].
• The chiral selector vancomycin was used either as mobile phase additive or bound as a chiral stationary phase (CSP) for the stereoselective separation of seven racemic nonsteroidal anti-inflammatory drugs (NSAIDs), fenoprofen, carprofen, flurbiprofen, indoprofen, flobufen, ketoprofen, and suprofen, by capillary liquid chromatography [2].
• Stereospecificity of flobufen metabolism in guinea pigs in vitro and in vivo: phase I of biotransformation [3].
• Chiral aspects of metabolism of antiinflammatory drug flobufen in human hepatocytes [4].
• Biotransformation of flobufen enantiomers in ruminant hepatocytes and subcellular fractions [5].

Biological context of Flobufen

• Stereospecificity and stereoselectivity of flobufen metabolic profile in male rats in vitro and in vivo: phase I of biotransformation [6].

Anatomical context of Flobufen

• It was detected upon the incubation of flobufen with liver microsomes isolated from all the animals tested [7].

Associations of Flobufen with other chemical compounds

• Maximum yield of reduced flobufen in experiments with rat and mouse liver microsomes was found after anaerobic incubation with NADPH [7].

Gene context of Flobufen

• 4-(2',4'- Difluorobiphenyl-4-yl)-2-methylbutyric acid (deoxoflobufen, VUFB 19053, CAS 847475-35-8) has been developed as a new omega-biphenyl-alkanoic acid and studied in comparison with the racemic form of 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid (flobufen, CAS 112344-52-2) [8].

Analytical, diagnostic and therapeutic context of Flobufen

• Enantioseparation of flobufen with cyclodextrins studied by capillary electrophoresis and NMR [9].
• The enantioselective behaviour of some underivatized 2-arylpropionic acids (profens) and flobufen by HPLC using a terguride-based chiral stationary phase was tested [10].
• Chiral resolution of flobufen by high performance liquid chromatography and capillary electrophoresis [11].
• Reduction of flobufen in pig hepatocytes: effect of pig breed (domestic, wild) and castration [12].
• The metabolism of the nonsteroidal antiinflammatory drug flobufen, 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid, was studied in primary cultures of human hepatocytes prepared by two-step collagenase perfusion of livers from four donors [4].

References