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Chemical Compound Review

suprofen     2-(4-thiophen-2- ylcarbonylphenyl)propanoic...

Synonyms: Maldocil, Profenal, Suprocil, TN-762, TN762, ...
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Disease relevance of TN 762


High impact information on TN 762


Chemical compound and disease context of TN 762


Biological context of TN 762


Anatomical context of TN 762


Associations of TN 762 with other chemical compounds


Gene context of TN 762

  • Ultraviolet-A irradiation of a suprofen (2-[4-2(2-thenoyl) phenyl]propionic acid) (SPF) buffered solution (pH 7.4) in the presence of supercoiled pBR322 DNA leads to single strand breaks with the formation of an open circular form and subsequent linearization of the plasmid [25].
  • Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen [17].
  • The mean pupillary area prior to IOL implantation was 6.3 sq mm larger (20% larger) in patients treated with suprofen than in patients receiving the placebo [26].
  • Metal complexes of anti-inflammatory drugs. Part VIII: Suprofen complex of copper(II) [27].
  • 5. The covalent binding of suprofen to proteins through its reactive acyl glucuronide may be of toxicological importance and relevant to the acute renal toxicity observed for suprofen in man [28].

Analytical, diagnostic and therapeutic context of TN 762


  1. Suprofen-induced transient flank pain and renal failure. Wolfe, S.M. N. Engl. J. Med. (1987) [Pubmed]
  2. The importance of adverse reaction reporting by physicians. Suprofen and the flank pain syndrome. Rossi, A.C., Bosco, L., Faich, G.A., Tanner, A., Temple, R. JAMA (1988) [Pubmed]
  3. Suprofen and acute renal failure. Davis, N.S., Spital, A., Kamm, D.E. Ann. Intern. Med. (1986) [Pubmed]
  4. Suprofen, acute renal failure, and hematuria. Abreo, K., LaBarre, J. Ann. Intern. Med. (1986) [Pubmed]
  5. Pharmacological analysis of hyperventilation in arthritic rats. Colpaert, F.C., Bervoets, K.J., Van den Hoogen, R.H. Pain (1987) [Pubmed]
  6. Suprofen-related nephrotoxicity. A distinct clinical syndrome. Hart, D., Ward, M., Lifschitz, M.D. Ann. Intern. Med. (1987) [Pubmed]
  7. T cell-derived antigen binding molecules play a role in the induction of airway hyperresponsiveness. Garssen, J., Nijkamp, F.P., Van Vugt, E., Van der Vliet, H., Van Loveren, H. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  8. The epidemiology of the acute flank pain syndrome from suprofen. Strom, B.L., West, S.L., Sim, E., Carson, J.L. Clin. Pharmacol. Ther. (1989) [Pubmed]
  9. Bioavailability and corneal anti-inflammatory effect of topical suprofen. Leibowitz, H.M., Ryan, W.J., Kupferman, A., DeSantis, L. Invest. Ophthalmol. Vis. Sci. (1986) [Pubmed]
  10. Effect of concurrent topical corticosteroid and NSAID therapy of experimental keratitis. Leibowitz, H.M., Ryan, W.J., Kupferman, A., DeSantis, L. Invest. Ophthalmol. Vis. Sci. (1986) [Pubmed]
  11. Immune hemolytic anemia associated with tolmetin and suprofen. van Dijk, B.A., Rico, P.B., Hoitsma, A., Kunst, V.A. Transfusion (1989) [Pubmed]
  12. Suprofen, a new peripheral analgesic. Capetola, R.J., Shriver, D.A., Rosenthale, M.E. J. Pharmacol. Exp. Ther. (1980) [Pubmed]
  13. Photodynamic lipid peroxidation by the photosensitizing nonsteroidal antiinflammatory drugs suprofen and tiaprofenic acid. Castell, J.V., Gomez-Lechon, M.J., Grassa, C., Martinez, L.A., Miranda, M.A., Tarrega, P. Photochem. Photobiol. (1994) [Pubmed]
  14. Effects of topical suprofen and flurbiprofen on the miosis produced by anterior chamber irrigation with cholinergic agonists. Zimm, J.L., Holmes, J.M., Anderson, C., Evans, L.S. Journal of cataract and refractive surgery. (1991) [Pubmed]
  15. Ibuprofen inhibits rat brain deamidation of anandamide at pharmacologically relevant concentrations. Mode of inhibition and structure-activity relationship. Fowler, C.J., Tiger, G., Stenström, A. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  16. Nonsteroid anti-inflammatory agents: regulators of the phagocytic secretion of lysosomal enzymes from guinea-pig neutrophils. Smith, R.J. J. Pharmacol. Exp. Ther. (1978) [Pubmed]
  17. Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen. O'Donnell, J.P., Dalvie, D.K., Kalgutkar, A.S., Obach, R.S. Drug Metab. Dispos. (2003) [Pubmed]
  18. Hydroxylation of the thiophene ring by hepatic monooxygenases. Evidence for 5-hydroxylation of 2-aroylthiophenes as a general metabolic pathway using a simple UV-visible assay. Neau, E., Dansette, P.M., Andronik, V., Mansuy, D. Biochem. Pharmacol. (1990) [Pubmed]
  19. Suprofen concentrations in human breast milk. Chaikin, P., Chasin, M., Kennedy, B., Silverman, B.K. Journal of clinical pharmacology. (1983) [Pubmed]
  20. The analgesic efficacy of suprofen in periodontal and oral surgical pain. Cooper, S.A., Wagenberg, B., Zissu, J., Kruger, G.O., Reynolds, D.C., Gallegos, L.T., Allwein, J.B., Desjardins, P.J., Friedmann, N., Danna, R.P. Pharmacotherapy (1986) [Pubmed]
  21. Molecular mechanism of drug photosensitization. 5. Photohemolysis sensitized by Suprofen. De Guidi, G., Chillemi, R., Costanzo, L.L., Giuffrida, S., Sortino, S., Condorelli, G. J. Photochem. Photobiol. B, Biol. (1994) [Pubmed]
  22. Dynamic kinetic resolution of suprofen thioester via coupled trioctylamine and lipase catalysis. Lin, C.N., Tsai, S.W. Biotechnol. Bioeng. (2000) [Pubmed]
  23. Allosteric and competitive displacement of drugs from human serum albumin by octanoic acid, as revealed by high-performance liquid affinity chromatography, on a human serum albumin-based stationary phase. Noctor, T.A., Wainer, I.W., Hage, D.S. J. Chromatogr. (1992) [Pubmed]
  24. Comparative efficacy of topically applied flurbiprofen, diclofenac, tolmetin, and suprofen for the treatment of experimentally induced blood-aqueous barrier disruption in dogs. Ward, D.A. Am. J. Vet. Res. (1996) [Pubmed]
  25. Molecular mechanism of drug photosensitization. 7. Photocleavage of DNA sensitized by suprofen. Condorelli, G., Constanzo, L.L., De Guidi, G., Giuffrida, S., Sortino, S. Photochem. Photobiol. (1995) [Pubmed]
  26. Reduction of pupillary constriction during cataract surgery using suprofen. Stark, W.J., Fagadau, W.R., Stewart, R.H., Crandall, A.S., deFaller, J.M., Reaves, T.A., Klein, P.E. Arch. Ophthalmol. (1986) [Pubmed]
  27. Metal complexes of anti-inflammatory drugs. Part VIII: Suprofen complex of copper(II). Underhill, A.E., Bougourd, S.A., Flugge, M.L., Gale, S.E., Gomm, P.S. J. Inorg. Biochem. (1993) [Pubmed]
  28. Covalent binding of suprofen acyl glucuronide to albumin in vitro. Smith, P.C., Liu, J.H. Xenobiotica (1993) [Pubmed]
  29. Suprofen treatment of contact lens-associated giant papillary conjunctivitis. Wood, T.S., Stewart, R.H., Bowman, R.W., McCulley, J.P., Reaves, T.A. Ophthalmology (1988) [Pubmed]
  30. Comparative bioavailability of suprofen after coadministration with food or milk. Chaikin, P., Marriott, T.B., Simon, D., Weintraub, H.S. Journal of clinical pharmacology. (1988) [Pubmed]
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