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Chemical Compound Review

Pristimerin     methyl (2R,4aS,6aS,6aR,14aS,14bR)- 10...

Synonyms: GNF-PF-476, CHEMBL54804, SureCN15020, BSPBio_003401, KBioGR_001942, ...
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Disease relevance of C08633


High impact information on C08633


Anatomical context of C08633


Associations of C08633 with other chemical compounds

  • A new quinonemethide triterpene named as salacin, has been isolated from the root bark of Salacia campestris in addition to the known pristimerin, maytenin, 20alpha-hydroxymaytenin, and netzahualcoyene [6].

Analytical, diagnostic and therapeutic context of C08633


  1. Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria. Wu, C.C., Chan, M.L., Chen, W.Y., Tsai, C.Y., Chang, F.R., Wu, Y.C. Mol. Cancer Ther. (2005) [Pubmed]
  2. Structural basis of potent antiperoxidation activity of the triterpene celastrol in mitochondria: effect of negative membrane surface charge on lipid peroxidation. Sassa, H., Kogure, K., Takaishi, Y., Terada, H. Free Radic. Biol. Med. (1994) [Pubmed]
  3. The triterpenoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages. Dirsch, V.M., Kiemer, A.K., Wagner, H., Vollmar, A.M. Eur. J. Pharmacol. (1997) [Pubmed]
  4. Insecticidal activity of Maytenus species (Celastraceae) nortriterpene quinone methides against codling moth, Cydia pomonella (L.) (Lepidoptera: tortricidae). Avilla, J., Teixidò, A., Velázquez, C., Alvarenga, N., Ferro, E., Canela, R. J. Agric. Food Chem. (2000) [Pubmed]
  5. Novel quinone methides from Salacia kraussii with in vitro antimalarial activity. Figueiredo, J.N., Räz, B., Séquin, U. J. Nat. Prod. (1998) [Pubmed]
  6. Antioxidant quinonemethide triterpenes from Salacia campestris. Carvalho, P.R., Silva, D.H., Bolzani, V.S., Furlan, M. Chem. Biodivers. (2005) [Pubmed]
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