Disease relevance of NSC 67354

• In the case of 2-chlorobiphenyl, toxicity was manifested as a diminished growth rate, which nevertheless effected rapid substrate utilization [1].
• Plasmid transfer in the 3-chlorobenzoate- and 3-chlorobiphenyl-dosed microcosms resulted in the selection of three phenotypic clusters of chlorobenzoate degraders, only one of which was closely related to the original pBRC60 (Tn5271) donor, Alcaligenes sp. strain BR60 [2].
• Transfer of the plasmid to the 3-chlorobenzoate-degrading bacterium Pseudomonas sp. B13 allowed the recipient to mineralize 3-chlorobiphenyl [3].

High impact information on NSC 67354

• In the case of 3-chlorobiphenyl, which generates 3-chlorocatechol more rapidly than does 2-chlorobiphenyl, toxicity was manifested as a decrease in viable cells during substrate utilization [1].
• C. demersum showed a decrease of photosynthesis after exposure to 3-chlorobiphenyl, although only significantly at 5 microgl(-1) [4].
• Toxicokinetics of DDE and 2-chlorobiphenyl in Chironomus tentans [5].
• Kinetics and products of the TiO2 photocatalytic degradation of 2-chlorobiphenyl in water [6].
• The half-life of the degradation process for 2-chlorobiphenyl is 20 minutes at pH 10 and 9 minutes at pH 3 in the presence of 25 mg/L of TiO2 [7].

Associations of NSC 67354 with other chemical compounds

• Activities of phenylcatechol 2,3-dioxygenase, benzoate dioxygenase, catechol 1,2-dioxygenase, chloromuconate cyloisomerase and 4-carboxymethylenebut-2-en-4-olide hydrolase were found in 3-chlorobiphenyl-grown cells [8].

Analytical, diagnostic and therapeutic context of NSC 67354

• The uptake, distribution, and exchange of chlorinated hydrocarbon insecticides (dieldrin and chlordecone) and biphenyls (2,4,5-2',4',5'-hexachlorobiphenyl and 3-chlorobiphenyl) among human lipoproteins was examined by fluorescence quenching, gel filtration, and ultrafiltration [9].

References