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Chemical Compound Review

BENZOYLCHOLINE     trimethyl-[2- (phenylcarbonyloxy) ethyl]azanium

Synonyms: AG-E-61370, SureCN2221655, TimTec1_001325, CTK4E8498, ZINC00125014, ...
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High impact information on BENZOYLCHOLINE


Biological context of BENZOYLCHOLINE

  • Substance P inhibited the hydrolysis of benzoylcholine (a good ester substrate) with a KI of 0.17 mM, indicating that substance P interacted with cholinesterase rather than with a trace contaminant [5].
  • The rate-limiting step for hydrolysis of the positively charged oxoester benzoylcholine (BzCh) by human butyrylcholinesterase (BuChE) is deacylation (k(3)), whereas it is acylation (k(2)) for hydrolysis of the homologous thioester benzoylthiocholine (BzSCh) [6].
  • The level of circulating atypical enzyme protein, determined immunologically, was about 30% lower when the enzyme came from an atypical rather than a usual phenotype, and the level of enzyme activity measured enzymatically at Vmax with either o-nitrophenylbutyrate or benzoylcholine as substrate showed approximately the same degree of reduction [7].

Associations of BENZOYLCHOLINE with other chemical compounds


Gene context of BENZOYLCHOLINE

  • The purpose of this work was to study the catalytic properties of rat butyrylcholinesterase with benzoylcholine (BzCh) and N-alkyl derivatives of BzCh (BCHn) as substrates [13].
  • Though these active site-directed inhibitors also influenced the benzoylcholine hydrolyzing activity of serum cholinesterase, we conclude from the data that dipeptidyl peptidase IV was the true Lys-Pro-p-nitroanilide cleaving activity [14].
  • Km value of his enzyme for benzoylcholine was 1.1 x 10(-5) mol/l, while that for normal controls was 2.3 x 10(-6) mol/l. In addition, isozymic alteration of his enzyme was observed [15].


  1. Comparison of atypical and usual human serum cholinesterase. Purification, number of active sites, substrate affinity, and turnover number. Lockridge, O., La Du, B.N. J. Biol. Chem. (1978) [Pubmed]
  2. Photolabeling the Torpedo nicotinic acetylcholine receptor with 4-azido-2,3,5,6-tetrafluorobenzoylcholine, a partial agonist. Nirthanan, S., Ziebell, M.R., Chiara, D.C., Hong, F., Cohen, J.B. Biochemistry (2005) [Pubmed]
  3. Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase. Masson, P., Legrand, P., Bartels, C.F., Froment, M.T., Schopfer, L.M., Lockridge, O. Biochemistry (1997) [Pubmed]
  4. Damped oscillatory hysteretic behaviour of butyrylcholinesterase with benzoylcholine as substrate. Masson, P., Goldstein, B.N., Debouzy, J.C., Froment, M.T., Lockridge, O., Schopfer, L.M. Eur. J. Biochem. (2004) [Pubmed]
  5. Substance P hydrolysis by human serum cholinesterase. Lockridge, O. J. Neurochem. (1982) [Pubmed]
  6. Rate-determining step of butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine and benzoylthiocholine. Volumetric study of wild-type and D70G mutant behavior. Masson, P., Bec, N., Froment, M.T., Nachon, F., Balny, C., Lockridge, O., Schopfer, L.M. Eur. J. Biochem. (2004) [Pubmed]
  7. Immunological comparison of the usual and atypical human serum cholinesterase phenotypes. Eckerson, H.W., Oseroff, A., Lockridge, O., La Du, B.N. Biochem. Genet. (1983) [Pubmed]
  8. Temperature, the benzoylcholine substrate, and fluoride inhibition of pseudocholinesterase. Wiesner, G., Hartwig, M., Gruber, M. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (2006) [Pubmed]
  9. Selective activity of butyrylcholinesterase in serum by a chemiluminescent assay. Yavo, B., Brunetti, I.L., da Fonseca, L.M., Catalani, L.H., Campa, A. Luminescence : the journal of biological and chemical luminescence. (2001) [Pubmed]
  10. The inhibitory effect of esmolol on human plasmacholinesterase. Barabas, E., Zsigmond, E.K., Kirkpatrick, A.F. Canadian Anaesthetists' Society journal. (1986) [Pubmed]
  11. The inhibitory effect of glycopyrrolate on human plasma-cholinesterase. Zsigmond, E.K., Winnie, A.P., Barabas, E., Wang, X.Y. Canadian Anaesthetists' Society journal. (1985) [Pubmed]
  12. Purification and characterization of butyrylcholine-hydrolyzing enzyme from Pseudomonas polycolor. Nagasawa, T., Sugisaki, H., Tani, Y., OgataK, n.u.l.l. Biochim. Biophys. Acta (1976) [Pubmed]
  13. Rat butyrylcholinesterase-catalysed hydrolysis of N-alkyl homologues of benzoylcholine. Hrabovská, A., Debouzy, J.C., Froment, M.T., Devínsky, F., Pauliková, I., Masson, P. FEBS J. (2006) [Pubmed]
  14. Contamination of highly purified human serum cholinesterase by dipeptidyl peptidase IV causing hydrolysis of substance P. Kaemmer, D., Neubert, K., Demuth, H.U., Barth, A. Die Pharmazie. (1986) [Pubmed]
  15. A variant serum cholinesterase and a confirmed point mutation at Gly-365 to Arg found in a patient with liver cirrhosis. Hada, T., Muratani, K., Ohue, T., Imanishi, H., Moriwaki, Y., Itoh, M., Amuro, Y., Higashino, K. Intern. Med. (1992) [Pubmed]
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