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Chemical Compound Review

butyrylcholine     2-butanoyloxyethyl-trimethyl- azanium

Synonyms: CHEMBL342902, HMDB13223, LS-65172, CTK8I5607, STL280268, ...
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Disease relevance of NSC97539


High impact information on NSC97539


Biological context of NSC97539


Anatomical context of NSC97539


Associations of NSC97539 with other chemical compounds


Gene context of NSC97539

  • Butyrylcholine is not a physiological substrate in mammalian brain, which makes the function of BuChE of difficult interpretation [13].
  • Labeling of the 85- and 79-kDa bands was inhibited by butyrylcholine, suggesting that these proteins have BuChE activity [14].
  • Toxin binding, localized to the outer and inner plexiform layers (OPL and IPL), was inhibited by micromolar concentrations of native alphaBgt and D-tubocurarine and by 1 mM acetyl- and butyrylcholine in both synaptic layers [15].
  • Recent work has shown that under certain conditions l-lactate is also able to reduce in vitro the POX inhibition of butyrylcholine- and acetylcholineesterase (BChE and AChE) [16].

Analytical, diagnostic and therapeutic context of NSC97539

  • MATERIALS AND METHODS: Phenylvalerate hydrolase and butyrylcholine activities were determined in serum of nine healthy human volunteers before and after addition of different concentrations of paraoxon [8].


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  2. Purification and characterization of butyrylcholine-hydrolyzing enzyme from Pseudomonas polycolor. Nagasawa, T., Sugisaki, H., Tani, Y., OgataK, n.u.l.l. Biochim. Biophys. Acta (1976) [Pubmed]
  3. Fundamental reaction mechanism for cocaine hydrolysis in human butyrylcholinesterase. Zhan, C.G., Zheng, F., Landry, D.W. J. Am. Chem. Soc. (2003) [Pubmed]
  4. Inhibitory action of 1-pyrene butyrylcholine and related compounds on choline uptake by cholinergic nerve endings. Dowdall, M.J., Barrantes, F.J., Stender, W., Jovin, T.M. J. Neurochem. (1976) [Pubmed]
  5. Effects of activin A/erythroid differentiation factor on erythroid and megakaryocytic differentiations of mouse erythroleukemia (Friend) cells: evidence for two distinct modes of cell response. Okafuji, K., Kaku, K., Seguchi, M., Tanaka, H., Azuno, Y., Kaneko, T. Exp. Hematol. (1995) [Pubmed]
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  7. The inhibition by D-tubocurarine of horse serum cholinesterase-catalyzed hydrolysis of butyrylcholine and benzoylcholine. Kamarić, L.M. Biochem. Pharmacol. (1975) [Pubmed]
  8. Paraoxon sensitive phenylvalerate hydrolase in assessing the severity of acute paraoxon poisoning. Petroianu, G., Kärcher, B., Kern, N., Bergler, W., Rüfer, R. J. Toxicol. Clin. Toxicol. (2001) [Pubmed]
  9. Substrate preferences of wild and a mutant house fly acetylcholinesterase and a comparison with the bovine erythrocyte enzyme. O'Brien, R.D., Tripathi, R.K., Howell, L.L. Biochim. Biophys. Acta (1978) [Pubmed]
  10. Cholinesterases in cardiac ganglia and modulation of canine intrinsic cardiac neuronal activity. Darvesh, S., MacDonald, S.E., Losier, A.M., Martin, E., Hopkins, D.A., Armour, J.A. J. Auton. Nerv. Syst. (1998) [Pubmed]
  11. Identification of unknown quaternary ammonium compounds in corneal epithelium and aqueous humor. Reubsaet, J.L., Ringvold, A. Journal of chromatographic science. (2005) [Pubmed]
  12. Flow microcalorimetric study of butyrylcholinesterase kinetics and inhibition. Debord, J., Verneuil, B., Bollinger, J.C., Merle, L., Dantoine, T. Anal. Biochem. (2006) [Pubmed]
  13. Cholinesterases: new roles in brain function and in Alzheimer's disease. Giacobini, E. Neurochem. Res. (2003) [Pubmed]
  14. Identification of serine esterases in tissue homogenates. Keshavarz-Shokri, A., Suntornwat, O., Kitos, P.A. Anal. Biochem. (1999) [Pubmed]
  15. Two types of receptors for alpha-bungarotoxin in the synaptic layers of the pigeon retina. Yazulla, S., Schmidt, J. Brain Res. (1977) [Pubmed]
  16. Pralidoxime and l-lactate effects in vitro on the inhibition of acetylcholinesterase by paraoxon: pralidoxime does not confer superior protection. Petroianu, G., Roth, C., Beha, U., Fisher, J., Bergler, W., Rüfer, R. Journal of applied toxicology : JAT. (2001) [Pubmed]
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