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Chemical Compound Review:

AG-D-58596 5-nitro-2-[2-(4-nitro-2- sulfo...

Synonyms: CBDivE_011453, CTK2G5482, CTK4B5948, AC1L2E5V, 128-42-7, ...

O'Neill, E.R. et al., Musch, M.W. et al., Laver, D.R. et al., Takazaki, S. et al., Gross, E. et al., et al.

Fortner, Lorenz, Paul, Laver, Bradley,

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High impact information on Dinitrostilbenedisulfonic acid

To determine whether increased ankyrin affinity is due to band 3 tetramer formation that occurs in volume expansion, cells were treated with pyridoxal 5-phosphate or 4,4'-dinitrostilbene-2,2'-disulfonic acid, two agents that increase tetramer formation under isoosmotic conditions [1].
The DNDS (4,4'-dinitrostilbene-2,2'-disulfonic acid) sensitivity of E699Q-mediated SO4(2-) efflux was indistinguishable from that of wt AE1-mediated Cl- efflux [2].
In addition to shifting the stoichiometry, 8-Br-cAMP caused a significant increase in the 4,4'-dinitrostilbene-2,2'-disulfonic acid (DNDS)-sensitive basolateral membrane conductance (GDS) of cells expressing pNBC1, but not kNBC1 [3].
Activation of skeletal muscle ryanodine receptors (RyRs) by suramin and disulfonic stilbene derivatives (Diisothiocyanostilbene-2',2'-disulfonic acid (DIDS), 4,4'-dibenzamidostilbene-2,2'-disulfonic acid (DBDS),and 4,4'-dinitrostilbene-2,2'-disulfonic acid (DNDS)) was investigated using planar bilayers [4].
Block of a sarcoplasmic reticulum anion channel (SCl channel) by disulfonic stilbene derivatives [DIDS, dibenzamidostilbene-2,2'-disulfonic acid (DBDS), and 4,4'-dinitrostilbene-2,2'-disulfonic acid (DNDS)] was investigated in planar bilayers using SO4(2-) as the conducting ion [5].

Biological context of Dinitrostilbenedisulfonic acid

The anion channel blocker, 4,4'-dinitrostilbene-2,2'-disulfonic acid prevents neuronal death and excitatory amino acid release during glycolysis inhibition in the hippocampus in vivo [6].
Chloride binding to the active sites in Band 3 was assessed from that portion of the total line width which was sensitive to 4,4'-dinitrostilbene-2,2'-disulfonic acid [7].

Anatomical context of Dinitrostilbenedisulfonic acid

To determine the role of Arg 901 in the conformational change induced by anion exchange, we analyzed HPG-modification of the membranes when 4,4'-dinitrostilbene-2,2'-disulfonic acid (DNDS) or diethypyrocarbonate (DEPC) was present [8].
We studied blockade by 4,4'-dinitrostilbene-2,2'-disulfonic acid (DNDS) of a secretory Cl- channel from colonic enterocyte plasma membrane vesicles incorporated into planar lipid bilayer membranes [9].

Associations of Dinitrostilbenedisulfonic acid with other chemical compounds

Steady-state ASL pH changed in parallel to changes in bath pH and was acidified by Na(+) or Cl(-) replacement but was not affected by the inhibitors amiloride, glibenclamide, or 4,4'-dinitrostilbene-2,2'-disulfonic acid [10].

Gene context of Dinitrostilbenedisulfonic acid

Relaxation to ATP or SP was unaffected by 4,4'-dinitrostilbene-2,2'-disulfonic acid (DNDS), and relaxation to SP was unaffected by either DIDS or DNDS [11].

References

High affinity binding of ankyrin induced by volume expansion in skate erythrocytes. Musch, M.W., Goldstein, L. J. Biol. Chem. (1996) [Pubmed]
Electrogenic sulfate/chloride exchange in Xenopus oocytes mediated by murine AE1 E699Q. Chernova, M.N., Jiang, L., Crest, M., Hand, M., Vandorpe, D.H., Strange, K., Alper, S.L. J. Gen. Physiol. (1997) [Pubmed]
Phosphorylation-induced modulation of pNBC1 function: distinct roles for the amino- and carboxy-termini. Gross, E., Fedotoff, O., Pushkin, A., Abuladze, N., Newman, D., Kurtz, I. J. Physiol. (Lond.) (2003) [Pubmed]
Regulation of the calcium release channel from skeletal muscle by suramin and the disulfonated stilbene derivatives DIDS, DBDS, and DNDS. O'Neill, E.R., Sakowska, M.M., Laver, D.R. Biophys. J. (2003) [Pubmed]
Disulfonic stilbene permeation and block of the anion channel from the sarcoplasmic reticulum of rabbit skeletal muscle. Laver, D.R., Bradley, K.M. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
The anion channel blocker, 4,4'-dinitrostilbene-2,2'-disulfonic acid prevents neuronal death and excitatory amino acid release during glycolysis inhibition in the hippocampus in vivo. Camacho, A., Montiel, T., Massieu, L. Neuroscience (2006) [Pubmed]
Inhibition of chloride binding to the anion transport site by diethylpyrocarbonate modification of Band 3. Hamasaki, N., Izuhara, K., Okubo, K., Kanazawa, Y., Omachi, A., Kleps, R.A. J. Membr. Biol. (1990) [Pubmed]
The functional role of arginine 901 at the C-terminus of the human anion transporter band 3 protein. Takazaki, S., Abe, Y., Kang, D., Li, C., Jin, X., Ueda, T., Hamasaki, N. J. Biochem. (2006) [Pubmed]
Stilbene disulfonate blockade of colonic secretory Cl- channels in planar lipid bilayers. Bridges, R.J., Worrell, R.T., Frizzell, R.A., Benos, D.J. Am. J. Physiol. (1989) [Pubmed]
Airway surface liquid pH in well-differentiated airway epithelial cell cultures and mouse trachea. Jayaraman, S., Song, Y., Verkman, A.S. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
Chloride channel function is linked to epithelium-dependent airway relaxation. Fortner, C.N., Lorenz, J.N., Paul, R.J. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]

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