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Chemical Compound Review

Lithocholate     (4R)-4- [(3R,5R,8S,9S,10S,13R,14S,17R) -3...

Synonyms: Prestwick_88, UPCMLD-DP153, CHEMBL1478, CCRIS 363, SureCN28449, ...
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Disease relevance of LITHOCHOLIC ACID


High impact information on LITHOCHOLIC ACID


Chemical compound and disease context of LITHOCHOLIC ACID


Biological context of LITHOCHOLIC ACID


Anatomical context of LITHOCHOLIC ACID


Associations of LITHOCHOLIC ACID with other chemical compounds


Gene context of LITHOCHOLIC ACID


Analytical, diagnostic and therapeutic context of LITHOCHOLIC ACID


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  2. Bile acid metabolism in cirrhosis. IV. Characterization of the abnormality in deoxycholic acid metabolism. Yoshida, T., McCormick, W.C., Swell, L., Vlahcevic, Z.R. Gastroenterology (1975) [Pubmed]
  3. Lithocholate cholestasis--sulfated glycolithocholate-induced intrahepatic cholestasis in rats. Yousef, I.M., Tuchweber, B., Vonk, R.J., Massé, D., Audet, M., Roy, C.C. Gastroenterology (1981) [Pubmed]
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  5. Metabolism of lithocholic and chenodeoxycholic acids in the squirrel monkey. Suzuki, H., Hamada, M., Kato, F. Gastroenterology (1985) [Pubmed]
  6. Bile acids: natural ligands for an orphan nuclear receptor. Parks, D.J., Blanchard, S.G., Bledsoe, R.K., Chandra, G., Consler, T.G., Kliewer, S.A., Stimmel, J.B., Willson, T.M., Zavacki, A.M., Moore, D.D., Lehmann, J.M. Science (1999) [Pubmed]
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  9. Effect of different levels of dietary corn oil and lard during the initiation phase of colon carcinogenesis in F344 rats. Reddy, B.S., Maruyama, H. J. Natl. Cancer Inst. (1986) [Pubmed]
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  11. Urinary excretion of lithocholic acid and its conjugates by the bile duct-ligated rat. Little, J.M., Zimniak, P., Radominska, A., Lehman, P., Lester, R. Hepatology (1991) [Pubmed]
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  14. Cholesterol and bile acid synthesis in Hep G2 cells. Metabolic effects of 26- and 7 alpha-hydroxycholesterol. Javitt, N.B., Budai, K. Biochem. J. (1989) [Pubmed]
  15. Metabolism of lithocholate in healthy man. II. Enterohepatic circulation. Cowen, A.E., Korman, M.G., Hofmann, A.F., Cass, O.W., Coffin, S.B. Gastroenterology (1975) [Pubmed]
  16. Comparative formation of lithocholic acid from chenodeoxycholic and ursodeoxycholic acids in the colon. Bazzoli, F., Fromm, H., Sarva, R.P., Sembrat, R.F., Ceryak, S. Gastroenterology (1982) [Pubmed]
  17. Fluorescent choleretic and cholestatic bile salts take different paths across the hepatocyte: transcytosis of glycolithocholate leads to an extensive redistribution of annexin II. Wilton, J.C., Matthews, G.M., Burgoyne, R.D., Mills, C.O., Chipman, J.K., Coleman, R. J. Cell Biol. (1994) [Pubmed]
  18. Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR). Sonoda, J., Xie, W., Rosenfeld, J.M., Barwick, J.L., Guzelian, P.S., Evans, R.M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
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  20. Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Uppal, H., Saini, S.P., Moschetta, A., Mu, Y., Zhou, J., Gong, H., Zhai, Y., Ren, S., Michalopoulos, G.K., Mangelsdorf, D.J., Xie, W. Hepatology (2007) [Pubmed]
  21. Cytotoxicity of bile salts against biliary epithelium: a study in isolated bile ductule fragments and isolated perfused rat liver. Benedetti, A., Alvaro, D., Bassotti, C., Gigliozzi, A., Ferretti, G., La Rosa, T., Di Sario, A., Baiocchi, L., Jezequel, A.M. Hepatology (1997) [Pubmed]
  22. Impaired lithocholate sulfation in the rhesus monkey: a possible mechanism for chenodeoxycholate toxicity. Gadacz, T.R., Allan, R.N., Mack, E., Hofmann, A.F. Gastroenterology (1976) [Pubmed]
  23. Hepatic alterations during total parenteral nutrition in patients with inflammatory bowel disease: a possible consequence of lithocholate toxicity. Fouin-Fortunet, H., Le Quernec, L., Erlinger, S., Lerebours, E., Colin, R. Gastroenterology (1982) [Pubmed]
  24. Metabolism of lethocholate in healthy man. I. Biotransformation and biliary excretion of intravenously administered lithocholate, lithocholylglycine, and their sulfates. Cowen, A.E., Korman, M.G., Hofmann, A.F., Cass, O.W. Gastroenterology (1975) [Pubmed]
  25. Metabolism of lithocholate in healthy man. III. Plasma disappearance of radioactivity after intravenous injection of labeled lithocholate and its derivatives. Cowen, A.E., Korman, M.G., Hofmann, A.F., Thomas, P.J. Gastroenterology (1975) [Pubmed]
  26. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Xie, W., Radominska-Pandya, A., Shi, Y., Simon, C.M., Nelson, M.C., Ong, E.S., Waxman, D.J., Evans, R.M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
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  28. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. Chen, S., Beaton, D., Nguyen, N., Senekeo-Effenberger, K., Brace-Sinnokrak, E., Argikar, U., Remmel, R.P., Trottier, J., Barbier, O., Ritter, J.K., Tukey, R.H. J. Biol. Chem. (2005) [Pubmed]
  29. Glucosidation of hyodeoxycholic acid by UDP-glucuronosyltransferase 2B7. Mackenzie, P., Little, J.M., Radominska-Pandya, A. Biochem. Pharmacol. (2003) [Pubmed]
  30. Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4. Jurutka, P.W., Thompson, P.D., Whitfield, G.K., Eichhorst, K.R., Hall, N., Dominguez, C.E., Hsieh, J.C., Haussler, C.A., Haussler, M.R. J. Cell. Biochem. (2005) [Pubmed]
  31. Ursodeoxycholic acid: a safe and effective agent for dissolving cholesterol gallstones. Tint, G.S., Salen, G., Colalillo, A., Graber, D., Verga, D., Speck, J., Shefer, S. Ann. Intern. Med. (1982) [Pubmed]
  32. Biochemical epidemiology of gallbladder cancer. Strom, B.L., Soloway, R.D., Rios-Dalenz, J., Rodriguez-Martinez, H.A., West, S.L., Kinman, J.L., Crowther, R.S., Taylor, D., Polansky, M., Berlin, J.A. Hepatology (1996) [Pubmed]
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