The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

SureCN224308     4-dimethylaminophenol

Synonyms: AG-G-26716, ANW-74896, AC1Q7AEO, AK-64702, KB-72403, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of dmap


High impact information on dmap


Biological context of dmap


Anatomical context of dmap


Gene context of dmap

  • During ferrihemoglobin formation, 4-(dimethylamino)phenol (DMAP), a potent cyanide antidote, forms a quinoid compound that is prone to sequential oxidation/addition reactions [13].

Analytical, diagnostic and therapeutic context of dmap


  1. Alterations in cellular intermediary metabolism by 4-dimethylaminophenol in the isolated perfused rat liver and the implications for 4-dimethylaminophenol toxicity. Elbers, R., Soboll, S., Kampffmeyer, H.G. Biochem. Pharmacol. (1980) [Pubmed]
  2. Hyperoxia in lethal methemoglobinemia: effects on oxygen transport, tissue oxygenation, and survival in pigs. Meier, J., Pape, A., Lauscher, P., Zwissler, B., Habler, O. Crit. Care Med. (2005) [Pubmed]
  3. Acute oral toxicity of 4-dimethylaminophenol to the gastrointestinal tract, liver and kidney of the rat. Marrs, T.C., Bright, J.E., Swanston, D.W. Arch. Toxicol. (1982) [Pubmed]
  4. Oxidation versus addition reactions of glutathione during the interactions with quinoid thioethers of 4-(dimethylamino)phenol. Ludwig, E., Eyer, P. Chem. Res. Toxicol. (1995) [Pubmed]
  5. Formation and transport of xenobiotic glutathione-S-conjugates in red cells. Eckert, K.G., Eyer, P. Biochem. Pharmacol. (1986) [Pubmed]
  6. Biotransformation of 4-dimethylaminophenol in the dog. Eyer, P., Gaber, H. Biochem. Pharmacol. (1978) [Pubmed]
  7. Toxicity evaluation of two treatment regimens for cyanide poisoning. Bhattacharya, R., Pant, S.C., Kumar, D., Dube, S.N. Journal of applied toxicology : JAT. (1995) [Pubmed]
  8. Effects of 4-dimethylaminophenol, Co2EDTA, or NaNO2 on cerebral blood flow and sinus blood homeostasis of dogs in connection with acute cyanide poisoning. Klimmek, R., Roddewig, C., Fladerer, H., Krettek, C., Weger, N. Toxicology (1983) [Pubmed]
  9. Effects of 4-dimethylaminophenol and Co2EDTA on circulation, respiration, and blood homeostasis in dogs. Klimmek, R., Fladerer, H., Szinicz, L., Weger, N., Kiese, M. Arch. Toxicol. (1979) [Pubmed]
  10. Pharmacokinetics of cyanide in poisoning of dogs, and the effect of 4-dimethylaminophenol or thiosulfate. Christel, D., Eyer, P., Hegemann, M., Kiese, M., Lörcher, W., Weger, N. Arch. Toxicol. (1977) [Pubmed]
  11. Effects of 4-dimethylaminophenol in rat kidneys, isolated rat kidney tubules and hepatocytes. Szinicz, L.L., Weger, N. Xenobiotica (1980) [Pubmed]
  12. Nephrotoxicity of aminophenols: effects of 4-dimethylaminophenol on isolated rat kidney tubules. Szinicz, L., Weger, N., Schneiderhan, W., Kiese, M. Arch. Toxicol. (1979) [Pubmed]
  13. Reactivity of glutathione adducts of 4-(dimethylamino)phenol. Formation of a highly reactive cyclization product. Ludwig, E., Eyer, P. Chem. Res. Toxicol. (1995) [Pubmed]
  14. Radical formation during autoxidation of 4-dimethylaminophenol and some properties of the reaction products. Eyer, P., Lengfelder, E. Biochem. Pharmacol. (1984) [Pubmed]
  15. Cerebral blood flow, circulation, and blood homeostasis of dogs during slow cyanide poisoning and after treatment with 4-dimethylaminophenol. Klimmek, R., Roddewig, C., Fladerer, H., Weger, N. Arch. Toxicol. (1982) [Pubmed]
  16. Effects and metabolic pathway of 4-dimethylaminophenol during kidney perfusion. Elbers, R., Kampffmeyer, H.G., Rabes, H. Xenobiotica (1980) [Pubmed]
WikiGenes - Universities