Disease relevance of dmap

• Alterations in cellular intermediary metabolism by 4-dimethylaminophenol in the isolated perfused rat liver and the implications for 4-dimethylaminophenol toxicity [1].
• A constant level of methemoglobinemia was maintained by continuous infusion of 4-dimethylaminophenol throughout a 6-hr follow-up period [2].
• Single oral doses up to 25 mg/kg body weight of methaemoglobin-inducing cyanide antidote, 4-dimethylaminophenol (DMAP) did not result in any gross or histological abnormality in the gastrointestinal tract, liver and kidneys of rats killed up to 24 h after the dose [3].

High impact information on dmap

• 4-(Dimethylamino)phenol (DMAP) is a potent cyanide antidote which forms many equivalents of ferrihemoglobin in vivo and in vitro [4].
• In vitro studies with freshly drawn human erythrocytes showed 4-dimethylaminophenol, a cyanide antidote, to be rapidly metabolized with the formation of a transient S,S-(2-dimethylamino-5-hydroxy-1,3-phenylene)bis-glutathione conjugate and a stable S,S,S-(2-dimethylamino-5-hydroxy-1,3,4-phenylene)tris-glutathione conjugate [5].
• Biotransformation of 4-dimethylaminophenol in the dog [6].
• Toxicological evaluation of two recently reported treatment protocols for cyanide--SN (sodium nitrite) + DMAP (4-dimethylaminophenol) and SN + HA (hydroxylamine)--was carried out in male rats [7].
• Effects of 4-dimethylaminophenol, Co2EDTA, or NaNO2 on cerebral blood flow and sinus blood homeostasis of dogs in connection with acute cyanide poisoning [8].

Biological context of dmap

• Effects of 4-dimethylaminophenol and Co2EDTA on circulation, respiration, and blood homeostasis in dogs [9].
• The effects of intravenously injected 4-dimethylaminophenol and Co2EDTA on peripheral circulation, respiration, acid-base balance, and several other physiological and biochemical parameters were studied on dogs [9].
• Pharmacokinetics of cyanide in poisoning of dogs, and the effect of 4-dimethylaminophenol or thiosulfate [10].
• 1. Addition of 4-dimethylaminophenol (DMAP) to suspensions of isolated rat kidney tubules increased extracellular lactate dehydrogenase (LDH) at concn. which did not markedly affect gluconeogenesis [11].

Anatomical context of dmap

• Nephrotoxicity of aminophenols: effects of 4-dimethylaminophenol on isolated rat kidney tubules [12].
• Acute oral toxicity of 4-dimethylaminophenol to the gastrointestinal tract, liver and kidney of the rat [3].
• Effects of 4-dimethylaminophenol in rat kidneys, isolated rat kidney tubules and hepatocytes [11].

Gene context of dmap

• During ferrihemoglobin formation, 4-(dimethylamino)phenol (DMAP), a potent cyanide antidote, forms a quinoid compound that is prone to sequential oxidation/addition reactions [13].

Analytical, diagnostic and therapeutic context of dmap

• 4-Dimethylaminophenol (DMAP), after intravenous injection, rapidly forms ferrihaemoglobin and has been successfully used in the treatment of cyanide poisoning [14].
• Cerebral blood flow, circulation, and blood homeostasis of dogs during slow cyanide poisoning and after treatment with 4-dimethylaminophenol [15].
• Effects and metabolic pathway of 4-dimethylaminophenol during kidney perfusion [16].

References