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Chemical Compound Review

CCRIS 3483     ethanoic acid; 2,3,8-trihydroxy-6-methyl-4...

Synonyms: AG-K-54134, CCG-39212, NSC-19048, KST-1A9629, NSC-727858, ...
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Disease relevance of gossypol

  • Gossypol treatment of endometriosis and uterine myomas in 15 cases was started with a daily dose of 20 mg of gossypol-acetic acid twice a day for 20 days as a loading dose, followed by 40 mg (20 mg twice weekly) [1].
  • These 18 ram lambs were divided into groups of 6 which were given either 0, 2.2 or 6.6 mg of GAA/kg body weight daily via gelatin capsules directly into the rumen [2].
  • The experimental results indicated that the PVP-gossypol complexes not only possessed the similar antifertility effect and acute toxicity to male mice as gossypol-acetic acid, but also reduced the irreversibility of the fertility as well [3].

High impact information on gossypol


Analytical, diagnostic and therapeutic context of gossypol


  1. Electron microscopic observations of the effects of gossypol on the human endometrium. Zu, P.D., Sun, Y.T., Cheng, J., Tian, L., Dang, M.Y., Han, M.L. Am. J. Obstet. Gynecol. (1984) [Pubmed]
  2. The effect of cottonseed components on testicular development in pubescent rams. Kramer, R.Y., Garner, D.L., Ericsson, S.A., Wesen, D.A., Downing, T.W., Redelman, D. Veterinary and human toxicology. (1991) [Pubmed]
  3. Studies on fertility control-the formation and antifertility effect of polyvinyl-pyrolidone-gossypol complex. Gu, Z.W., Jiang, Y., Feng, X.D. Biomaterials, medical devices, and artificial organs. (1984) [Pubmed]
  4. Analysis of gossypol and gossypol-acetic acid by high-performance liquid chromatography. Marcelle, G.B., Ahmed, M.S., Pezzuto, J.M., Cordell, G.A., Waller, D.P., Soejarto, D.D., Fong, H.H. Journal of pharmaceutical sciences. (1984) [Pubmed]
  5. Inhibition studies on LDH isoenzyme purified from Uromastix testes. Javed, M.U., Waqar, M.A. J. Enzym. Inhib. (1996) [Pubmed]
  6. Effect of gossypol-acetic acid on calcium transport and ATPase activity in plasma membranes from ram and bull spermatozoa. Breitbart, H., Rubinstein, S., Nass-Arden, L. Int. J. Androl. (1984) [Pubmed]
  7. Ultrastructural analysis of rat testes after gossypol acetic acid (GAA) treatment. Rovan, E., Weinbauer, G.F., Frick, J., Adam, H. Urol. Res. (1983) [Pubmed]
  8. Subchronic oral administration of gossypol-acetic acid (GAA) alters the distribution and utilization of radioiron in male rats. Reynolds, J.M., Tone, J.N. Drug and chemical toxicology. (1988) [Pubmed]
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