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Chemical Compound Review:

CCRIS 3483 ethanoic acid; 2,3,8-trihydroxy-6-methyl-4...

Synonyms: AG-K-54134, CCG-39212, NSC-19048, KST-1A9629, NSC-727858, ...

This record was replaced with 3503.

Gu, Z.W. et al., Zu, P.D. et al., Kramer, R.Y. et al., Javed, M.U. et al., Reynolds, J.M. et al., et al.

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Disease relevance of gossypol

Gossypol treatment of endometriosis and uterine myomas in 15 cases was started with a daily dose of 20 mg of gossypol-acetic acid twice a day for 20 days as a loading dose, followed by 40 mg (20 mg twice weekly) [1].
These 18 ram lambs were divided into groups of 6 which were given either 0, 2.2 or 6.6 mg of GAA/kg body weight daily via gelatin capsules directly into the rumen [2].
The experimental results indicated that the PVP-gossypol complexes not only possessed the similar antifertility effect and acute toxicity to male mice as gossypol-acetic acid, but also reduced the irreversibility of the fertility as well [3].

High impact information on gossypol

Analysis of gossypol and gossypol-acetic acid by high-performance liquid chromatography [4].
Oxalate caused non-competitive inhibition (Ki app = IC50 = 0.15 mM) of the forward reaction, NADH was more effective in blocking inhibition by GAA than pyruvate [5].
Effect of gossypol-acetic acid on calcium transport and ATPase activity in plasma membranes from ram and bull spermatozoa [6].
Ultrastructural analysis of rat testes after gossypol acetic acid (GAA) treatment [7].

Analytical, diagnostic and therapeutic context of gossypol

Subchronic oral administration of gossypol-acetic acid (GAA) alters the distribution and utilization of radioiron in male rats [8].

References

Electron microscopic observations of the effects of gossypol on the human endometrium. Zu, P.D., Sun, Y.T., Cheng, J., Tian, L., Dang, M.Y., Han, M.L. Am. J. Obstet. Gynecol. (1984) [Pubmed]
The effect of cottonseed components on testicular development in pubescent rams. Kramer, R.Y., Garner, D.L., Ericsson, S.A., Wesen, D.A., Downing, T.W., Redelman, D. Veterinary and human toxicology. (1991) [Pubmed]
Studies on fertility control-the formation and antifertility effect of polyvinyl-pyrolidone-gossypol complex. Gu, Z.W., Jiang, Y., Feng, X.D. Biomaterials, medical devices, and artificial organs. (1984) [Pubmed]
Analysis of gossypol and gossypol-acetic acid by high-performance liquid chromatography. Marcelle, G.B., Ahmed, M.S., Pezzuto, J.M., Cordell, G.A., Waller, D.P., Soejarto, D.D., Fong, H.H. Journal of pharmaceutical sciences. (1984) [Pubmed]
Inhibition studies on LDH isoenzyme purified from Uromastix testes. Javed, M.U., Waqar, M.A. J. Enzym. Inhib. (1996) [Pubmed]
Effect of gossypol-acetic acid on calcium transport and ATPase activity in plasma membranes from ram and bull spermatozoa. Breitbart, H., Rubinstein, S., Nass-Arden, L. Int. J. Androl. (1984) [Pubmed]
Ultrastructural analysis of rat testes after gossypol acetic acid (GAA) treatment. Rovan, E., Weinbauer, G.F., Frick, J., Adam, H. Urol. Res. (1983) [Pubmed]
Subchronic oral administration of gossypol-acetic acid (GAA) alters the distribution and utilization of radioiron in male rats. Reynolds, J.M., Tone, J.N. Drug and chemical toxicology. (1988) [Pubmed]

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