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Chemical Compound Review

COPPER     copper

Synonyms: Kupfer, cuivre, cuprum, Rame, Tatum-T, ...
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Disease relevance of copper


High impact information on copper

  • In contrast, for the (trimethylsilyl)methyl and vinyl groups, the selectivity depends on the kinetics of reductive elimination of the Cu(III) intermediate [2].
  • Finally, oxidation of Cu(2+) to Cu(3+) has been studied by cyclic voltammetry in water, which revealed that the redox reaction occurs only when the copper cation is within the diamino-diimido compartment [3].
  • In the solid state the Cu(III) complexes were mainly characterized by single-crystal X-ray diffraction analysis, whereas in solution their structural characterization was mainly based on (1)H NMR spectroscopy given the diamagnetic nature of the d(8) square-planar Cu(III) complexes [4].
  • The results from both types of compounds indicate that the binding site is located in a pocket near the type 1 copper center [5].
  • Direct STM investigation of cinchona alkaloid adsorption on Cu(III) [6].

Biological context of copper


Analytical, diagnostic and therapeutic context of copper


  1. Alcaligenes xylosoxidans dissimilatory nitrite reductase: alanine substitution of the surface-exposed histidine 139l ligand of the type 1 copper center prevents electron transfer to the catalytic center. Prudêncio, M., Sawers, G., Fairhurst, S.A., Yousafzai, F.K., Eady, R.R. Biochemistry (2002) [Pubmed]
  2. Thermodynamic and kinetic control in selective ligand transfer in conjugate addition of mixed organocuprate Me(X)CuLi. Yamanaka, M., Nakamura, E. J. Am. Chem. Soc. (2005) [Pubmed]
  3. Single and double pH-driven Cu2+ translocation with molecular rearrangement in alkyne-functionalized polyamino polyamido ligands. Aurora, A., Boiocchi, M., Dacarro, G., Foti, F., Mangano, C., Pallavicini, P., Patroni, S., Taglietti, A., Zanoni, R. Chemistry (Weinheim an der Bergstrasse, Germany) (2006) [Pubmed]
  4. Fine-tuning the electronic properties of highly stable organometallic Cu(III) complexes containing monoanionic macrocyclic ligands. Xifra, R., Ribas, X., Llobet, A., Poater, A., Duran, M., Solà, M., Stack, T.D., Benet-Buchholz, J., Donnadieu, B., Mahía, J., Parella, T. Chemistry (Weinheim an der Bergstrasse, Germany) (2005) [Pubmed]
  5. Probing the location of the substrate binding site of ascorbate oxidase near type 1 copper: an investigation through spectroscopic, inhibition and docking studies. Santagostini, L., Gullotti, M., De Gioia, L., Fantucci, P., Franzini, E., Marchesini, A., Monzani, E., Casella, L. Int. J. Biochem. Cell Biol. (2004) [Pubmed]
  6. Direct STM investigation of cinchona alkaloid adsorption on Cu(III). Xu, Q.M., Wang, D., Han, M.J., Wan, L.J., Bai, C.L. Langmuir : the ACS journal of surfaces and colloids. (2004) [Pubmed]
  7. DNA damage induced by sulfite autoxidation catalyzed by copper(II) tetraglycine complexes. Moreno, R.G., Alipázaga, M.V., Medeiros, M.H., Coichev, N. Dalton transactions (Cambridge, England : 2003) (2005) [Pubmed]
  8. A study of a series of recombinant fungal laccases and bilirubin oxidase that exhibit significant differences in redox potential, substrate specificity, and stability. Xu, F., Shin, W., Brown, S.H., Wahleithner, J.A., Sundaram, U.M., Solomon, E.I. Biochim. Biophys. Acta (1996) [Pubmed]
  9. Molecular analysis of a laccase gene from the white rot fungus Pycnoporus cinnabarinus. Eggert, C., LaFayette, P.R., Temp, U., Eriksson, K.E., Dean, J.F. Appl. Environ. Microbiol. (1998) [Pubmed]
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