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Chemical Compound Review

Droxaryl     2-(4-butoxyphenyl)-N-hydroxy- ethanamide

Synonyms: Flogicid, Norfemac, Paraderm, Parfenac, Parfenal, ...
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Disease relevance of bufexamac


High impact information on bufexamac

  • Bufexamac crystals in synovial fluid analysis [6].
  • The effect of bufexamac on UV-irradiation-induced lipid peroxidation was investigated [7].
  • The influence of bufexamac on the concentration of hydroxyl radicals generated by the Fenton system was examined using the spin trapping technique [7].
  • The results suggest a new interpretation of the controversially debated mechanism of action of bufexamac and indicate possible reasons for its eczema provoking potential [7].
  • PROCEDURE: Horses were randomly allocated into 4 groups consisting of 5 horses each, and 20, 60, or 100 mg of bufexamac or 1 ml of sterile saline (0.9% NaCl) solution (control) was injected into 1 intercarpal joint at weekly intervals for 6 treatments (days 0, 7, 14, 21, 28, and 35) [8].

Chemical compound and disease context of bufexamac


Anatomical context of bufexamac


Associations of bufexamac with other chemical compounds


Analytical, diagnostic and therapeutic context of bufexamac


  1. Bufexamac: a review of its pharmacological properties and therapeutic efficacy in inflammatory dermatoses. Brogden, R.N., Pinder, R.M., Sawyer, P.R., Speight, T.M., Avery, G.S. Drugs (1975) [Pubmed]
  2. Evaluation of the efficacy of topical bufexamac in epidermolysis bullosa simplex. A double-blind placebo-controlled crossover trial. Fine, J.D., Johnson, L. Archives of dermatology. (1988) [Pubmed]
  3. General dermatologic use of hydroxamic acid. Solano, E. Clinical therapeutics. (1980) [Pubmed]
  4. Contact sensitivity to bufexamac. Lachapelle, J.M. Contact Derm. (1975) [Pubmed]
  5. Allergic contact dermatitis from bufexamac cream. Corazza, M., Roveggio, C., Virgili, A. Contact Derm. (1993) [Pubmed]
  6. Bufexamac crystals in synovial fluid analysis. Moens, C.H., Moens, D., Moens, P.H. Ann. Rheum. Dis. (1985) [Pubmed]
  7. Examinations of the antioxidative properties of the topically administered drug bufexamac reveal new insights into its mechanism of action. Trommer, H., Plätzer, M., Raith, K., Wohlrab, W., Podhaisky, H.P., Neubert, R.H. J. Pharm. Pharmacol. (2003) [Pubmed]
  8. Effects of intra-articular injections of bufexamac suspension in healthy horses. Suominen, M.M., Tulamo, R.M., Anttila, M.O., Sankari, S.M., Király, K., Lapveteläinen, T., Helminen, H.J. Am. J. Vet. Res. (2001) [Pubmed]
  9. Changes in MMP-2 and -9 activity and MMP-8 reactivity after amphotericin B induced synovitis and treatment with bufexamac. Marttinen, P.H., Raulo, S.M., Suominen, M.M., Tulamo, R.M. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine. (2006) [Pubmed]
  10. Repeated application of dinitrochlorobenzene to the ears of sensitized guinea pigs: a preliminary characterization of a potential new animal model for contact eczema in humans. Boyera, N., Cavey, D., Bouclier, M., Burg, G., Rossio, P., Hensby, C. Skin Pharmacol. (1992) [Pubmed]
  11. Effects of intra-articular injections of bufexamac suspension on amphotericin B-induced aseptic arthritis in horses. Suominen, M.M., Tulamo, R.M., Puupponen, L.M., Sankari, S.M. Am. J. Vet. Res. (1999) [Pubmed]
  12. Determination of bufexamac in cream and ointment by high-performance liquid chromatography. Kamata, K., Akiyama, K. J. Chromatogr. (1986) [Pubmed]
  13. Delayed contact hypersensitivity to non-steroidal anti-inflammatory drugs. Gniazdowska, B., Ruëff, F., Przybilla, B. Contact Derm. (1999) [Pubmed]
  14. Efficacy of bufexamac (NFN) cream in skin diseases. A double-blind multicentre trial. Christiansen, J.V., Gadborg, E., Kleiter, I., Ludvigsen, K., Meier, C.H., Norholm, A., Reiter, H., Reymann, F., Raaschou-Nielsen, W., Sondergaard, M., Unna, P., Wehnert, R. Dermatologica (1977) [Pubmed]
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