Disease relevance of bufexamac

• Bufexamac: a review of its pharmacological properties and therapeutic efficacy in inflammatory dermatoses [1].
• Evaluation of the efficacy of topical bufexamac in epidermolysis bullosa simplex. A double-blind placebo-controlled crossover trial [2].
• Evaluation and grading of signs and symptoms were done at initial visit; changes resulting from topical treatment with bufexamac cream were monitored at weekly intervals [3].
• Contact sensitivity to bufexamac [4].
• Allergic contact dermatitis from bufexamac cream [5].

High impact information on bufexamac

• Bufexamac crystals in synovial fluid analysis [6].
• The effect of bufexamac on UV-irradiation-induced lipid peroxidation was investigated [7].
• The influence of bufexamac on the concentration of hydroxyl radicals generated by the Fenton system was examined using the spin trapping technique [7].
• The results suggest a new interpretation of the controversially debated mechanism of action of bufexamac and indicate possible reasons for its eczema provoking potential [7].
• PROCEDURE: Horses were randomly allocated into 4 groups consisting of 5 horses each, and 20, 60, or 100 mg of bufexamac or 1 ml of sterile saline (0.9% NaCl) solution (control) was injected into 1 intercarpal joint at weekly intervals for 6 treatments (days 0, 7, 14, 21, 28, and 35) [8].

Chemical compound and disease context of bufexamac

• Changes in MMP-2 and -9 activity and MMP-8 reactivity after amphotericin B induced synovitis and treatment with bufexamac [9].
• In agreement with clinical observations in humans, topical treatment of challenged animals with corticosteroid (1% hydrocortisone) reduced the oedema, hyperplasia, papillomatosis, and leucocyte infiltrates, while application of 5% bufexamac (a non-steroidal drug) was associated with a slight enhancement of the inflammatory response [10].

Anatomical context of bufexamac

• OBJECTIVE: To evaluate the effects of intra-articular (IA) injections of bufexamac in horses, focusing particularly on the effects of bufexamac on articular cartilage [8].

Associations of bufexamac with other chemical compounds

• Effects of intra-articular injections of bufexamac suspension on amphotericin B-induced aseptic arthritis in horses [11].

Analytical, diagnostic and therapeutic context of bufexamac

• Determination of bufexamac in cream and ointment by high-performance liquid chromatography [12].
• Effects of intra-articular injections of bufexamac suspension in healthy horses [8].
• These patch test results corresponded well to the individual history in 11 individuals (including 10 patients with reactions to bufexamac), and in 2 patients the clinical relevance of the reactions was probable [13].
• Efficacy of bufexamac (NFN) cream in skin diseases. A double-blind multicentre trial [14].

References