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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Carpal Joints

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Disease relevance of Carpal Joints

  • Forty-seven of 100 consecutive juvenile rheumatoid arthritis patients with wrist arthritis were found to have ankylosis at the carpal joints. this finding was significantly more frequent in juvenile than in adult rheumatoid arthritis patients [1].
  • Our patients were elderly men who presented with typical symptoms of abrupt onset of synovitis of the wrist, carpal joints, metacarpophalangeal, proximal interphalangeal, distal interphalangeal joints, and flexor tendons, associated with remarkable pitting edema of the hands [2].
  • A solitary mass overlying the right carpal joint region's skin in an 18-year-old female Père David's deer (Elaphurus davidianus) was surgically excised and histologically diagnosed as a squamous cell carcinoma (SCC) [3].

High impact information on Carpal Joints

  • METHODS: Eight 2-year-old female horses had MPA or diluent administered into contralateral middle carpal joints at 14 day intervals for a total of four treatments per horse [4].
  • Using mild adjuvant-mediated monoarthritis of the left carpal joint we found significant increases in substance P (+69%) and calcitonin gene-related peptide (CGRP; +204+), but not somatostatin in ipsilateral C6/7 DRG [5].
  • Pharmacokinetic-pharmacodynamic relationships and dose response to meloxicam in horses with induced arthritis in the right carpal joint [6].
  • PROCEDURE: Horses were randomly allocated into 4 groups consisting of 5 horses each, and 20, 60, or 100 mg of bufexamac or 1 ml of sterile saline (0.9% NaCl) solution (control) was injected into 1 intercarpal joint at weekly intervals for 6 treatments (days 0, 7, 14, 21, 28, and 35) [7].
  • PROCEDURE: Aseptic arthritis was induced in the right intercarpal joint by i.a. injection of amphotericin B (20 mg) [8].

Chemical compound and disease context of Carpal Joints


Anatomical context of Carpal Joints


Associations of Carpal Joints with chemical compounds

  • RESULTS: During the early part of the stance phase, the carpal joint had oscillating periods of energy generation and absorption against a predominant flexor moment, then an absorption phase at the end of the stance phase, as the carpus flexed into swing against an extensor moment [15].
  • One middle carpal joint of each horse was injected 3 times with 100 mg of 6-alpha-methylprednisolone acetate, at 14-day intervals [16].
  • Blue latex solution (20 +/- 2.5 ml) was injected into the middle carpal joint, and the specimens were frozen in extension [17].
  • Synovial fluid samples were obtained aseptically from both middle carpal joints on days 0, 13, 20, 27, 34, and 72 after surgery, and total protein, inflammatory cell, hyaluronate, glycosaminoglycan, and prostaglandin E2 concentrations were measured in each sample [18].
  • Effect of betamethasone and exercise on equine carpal joints with osteochondral fragments [19].

Gene context of Carpal Joints


  1. Carpal ankylosis in juvenile rheumatoid arthritis. Maldonado-Cocco, J.A., García-Morteo, O., Spindler, A.J., Hübscher, O., Gagliardi, S. Arthritis Rheum. (1980) [Pubmed]
  2. RS3PE syndrome: no evidence for retroviruses. Russell, E.B., McCarty, D.J., Schwab, J., Hanel, D., Komorowski, R., Stransky, G., Gay, S. J. Rheumatol. (1994) [Pubmed]
  3. Squamous cell carcinoma of the skin in a Père David's deer (Elaphurus davidianus). Agrimi, U., Morelli, L., Di Guardo, G. J. Wildl. Dis. (1993) [Pubmed]
  4. The effects of intra-articular methylprednisolone and exercise on the mechanical properties of articular cartilage in the horse. Murray, R.C., DeBowes, R.M., Gaughan, E.M., Zhu, C.F., Athanasiou, K.A. Osteoarthr. Cartil. (1998) [Pubmed]
  5. Increase in substance P and CGRP, but not somatostatin content of innervating dorsal root ganglia in adjuvant monoarthritis in the rat. Smith, G.D., Harmar, A.J., McQueen, D.S., Seckl, J.R. Neurosci. Lett. (1992) [Pubmed]
  6. Pharmacokinetic-pharmacodynamic relationships and dose response to meloxicam in horses with induced arthritis in the right carpal joint. Toutain, P.L., Cester, C.C. Am. J. Vet. Res. (2004) [Pubmed]
  7. Effects of intra-articular injections of bufexamac suspension in healthy horses. Suominen, M.M., Tulamo, R.M., Anttila, M.O., Sankari, S.M., Király, K., Lapveteläinen, T., Helminen, H.J. Am. J. Vet. Res. (2001) [Pubmed]
  8. Effects of intra-articular injections of bufexamac suspension on amphotericin B-induced aseptic arthritis in horses. Suominen, M.M., Tulamo, R.M., Puupponen, L.M., Sankari, S.M. Am. J. Vet. Res. (1999) [Pubmed]
  9. Effect of induced synovial inflammation on pharmacokinetics and synovial concentration of sodium ampicillin and kanamycin sulfate after systemic administration in ponies. Firth, E.C., Klein, W.R., Nouws, J.F., Wensing, T. J. Vet. Pharmacol. Ther. (1988) [Pubmed]
  10. Evaluation of intra-articularly administered sodium monoiodoacetate-induced chemical injury to articular cartilage of horses. Gustafson, S.B., Trotter, G.W., Norrdin, R.W., Wrigley, R.H., Lamar, C. Am. J. Vet. Res. (1992) [Pubmed]
  11. Substance P in the synovial membrane and fluid of the equine middle carpal joint. Caron, J.P., Bowker, R.M., Abhold, R.H., Toppin, D.S., Sonea, I.M., Vex, K.B. Equine Vet. J. (1992) [Pubmed]
  12. Effects of intra-articular administration of dimethylsulfoxide on chemically induced synovitis in immature horses. Welch, R.D., Watkins, J.P., DeBowes, R.M., Leipold, H.W. Am. J. Vet. Res. (1991) [Pubmed]
  13. The effect of ebselen on T-lymphocyte migration to arthritic joints and dermal inflammatory reactions in the rat. Gao, J.X., Issekutz, A.C. Int. J. Immunopharmacol. (1994) [Pubmed]
  14. Intra-articular corticosteroid- and exercise-induced arthropathy in a horse. Owen, R.A., Marsh, J.A., Hallett, F.R., Lumsden, J.H., Johnson, J. J. Am. Vet. Med. Assoc. (1984) [Pubmed]
  15. Forelimb joint moments and power during the walking stance phase of horses. Colborne, G.R., Lanovaz, J.L., Sprigings, E.J., Schamhardt, H.C., Clayton, H.M. Am. J. Vet. Res. (1998) [Pubmed]
  16. Effects of intra-articular administration of methylprednisolone acetate on normal equine articular cartilage. Trotter, G.W., McIlwraith, C.W., Yovich, J.V., Norrdin, R.W., Wrigley, R.H., Lamar, C.H. Am. J. Vet. Res. (1991) [Pubmed]
  17. Communications and boundaries of the middle carpal and carpometacarpal joints in horses. Ford, T.S., Ross, M.W., Orsini, P.G. Am. J. Vet. Res. (1988) [Pubmed]
  18. Effects of intravenous administration of sodium hyaluronate on carpal joints in exercising horses after arthroscopic surgery and osteochondral fragmentation. Kawcak, C.E., Frisbie, D.D., Trotter, G.W., McIlwraith, C.W., Gillette, S.M., Powers, B.E., Walton, R.M. Am. J. Vet. Res. (1997) [Pubmed]
  19. Effect of betamethasone and exercise on equine carpal joints with osteochondral fragments. Foland, J.W., McIlwraith, C.W., Trotter, G.W., Powers, B.E., Lamar, C.H. Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons. (1994) [Pubmed]
  20. Expression of TNF alpha in arthritis caused by caprine arthritis encephalitis virus. Lechner, F., Vogt, H.R., Seow, H.F., von Bodungen, U., Bertoni, G., Zurbriggen, A., Peterhans, E. Vet. Immunol. Immunopathol. (1996) [Pubmed]
  21. Carpal tunnel syndrome secondary to ulnar bursa distension from the intercarpal joint: report of a case. Linscheid, R.L. The Journal of hand surgery. (1979) [Pubmed]
  22. Retroviral arthritis: phenotypic analysis of cells in the synovial fluid of sheep with inflammatory synovitis associated with visna virus infection. Harkiss, G.D., Watt, N.J., King, T.J., Williams, J., Hopkins, J. Clin. Immunol. Immunopathol. (1991) [Pubmed]
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