Disease relevance of Carpal Joints

• Forty-seven of 100 consecutive juvenile rheumatoid arthritis patients with wrist arthritis were found to have ankylosis at the carpal joints. this finding was significantly more frequent in juvenile than in adult rheumatoid arthritis patients [1].
• Our patients were elderly men who presented with typical symptoms of abrupt onset of synovitis of the wrist, carpal joints, metacarpophalangeal, proximal interphalangeal, distal interphalangeal joints, and flexor tendons, associated with remarkable pitting edema of the hands [2].
• A solitary mass overlying the right carpal joint region's skin in an 18-year-old female Père David's deer (Elaphurus davidianus) was surgically excised and histologically diagnosed as a squamous cell carcinoma (SCC) [3].

High impact information on Carpal Joints

• METHODS: Eight 2-year-old female horses had MPA or diluent administered into contralateral middle carpal joints at 14 day intervals for a total of four treatments per horse [4].
• Using mild adjuvant-mediated monoarthritis of the left carpal joint we found significant increases in substance P (+69%) and calcitonin gene-related peptide (CGRP; +204+), but not somatostatin in ipsilateral C6/7 DRG [5].
• Pharmacokinetic-pharmacodynamic relationships and dose response to meloxicam in horses with induced arthritis in the right carpal joint [6].
• PROCEDURE: Horses were randomly allocated into 4 groups consisting of 5 horses each, and 20, 60, or 100 mg of bufexamac or 1 ml of sterile saline (0.9% NaCl) solution (control) was injected into 1 intercarpal joint at weekly intervals for 6 treatments (days 0, 7, 14, 21, 28, and 35) [7].
• PROCEDURE: Aseptic arthritis was induced in the right intercarpal joint by i.a. injection of amphotericin B (20 mg) [8].

Chemical compound and disease context of Carpal Joints

• Four of the five pony mares were then given the i.m. kanamycin/ampicillin combination 4 h after acute synovitis and fever had been induced by injection of lipopolysaccharide into the left intercarpal joint [9].

Anatomical context of Carpal Joints

• Three doses of sodium monoiodoacetate (MIA) were used to induce degenerative changes in articular cartilage in middle carpal joints of horses [10].
• Substance P in the synovial membrane and fluid of the equine middle carpal joint [11].
• Eight days after injection, synovial fluid was obtained and the right middle carpal joints were injected with 2 ml of 40% DMSO in lactated Ringer solution [12].
• Treatment of rats with AA with ebselen (100 mg/kg/day) p.o. for three days significantly reduced accumulation of 111In-labelled spleen T-cells (SPLT) in the arthritic joints, including forepaws, carpal joints, hindpaws and talar joints, and in all the above dermal inflammatory reactions [13].
• Methylprednisolone acetate was injected repeatedly into both intercarpal joints of a horse that had a 3rd carpal bone fracture in 1 limb [14].

Associations of Carpal Joints with chemical compounds

• RESULTS: During the early part of the stance phase, the carpal joint had oscillating periods of energy generation and absorption against a predominant flexor moment, then an absorption phase at the end of the stance phase, as the carpus flexed into swing against an extensor moment [15].
• One middle carpal joint of each horse was injected 3 times with 100 mg of 6-alpha-methylprednisolone acetate, at 14-day intervals [16].
• Blue latex solution (20 +/- 2.5 ml) was injected into the middle carpal joint, and the specimens were frozen in extension [17].
• Synovial fluid samples were obtained aseptically from both middle carpal joints on days 0, 13, 20, 27, 34, and 72 after surgery, and total protein, inflammatory cell, hyaluronate, glycosaminoglycan, and prostaglandin E2 concentrations were measured in each sample [18].
• Effect of betamethasone and exercise on equine carpal joints with osteochondral fragments [19].

Gene context of Carpal Joints

• TNF alpha expressing cells were detected by in situ hybridization in synovial membranes of arthritic carpal joints [20].
• Carpal tunnel syndrome secondary to ulnar bursa distension from the intercarpal joint: report of a case [21].
• A high proportion of these cells also stained for CD1 in both normal and infected animals, but were significantly elevated in number in the carpal joints of infected sheep [22].

References