Disease relevance of dioctyltin

• Dextran sulfate, iota-carrageenan, lambda-carrageenan, dipropyltin dichloride, and di-n-octyltin dichloride, at concentrations which did not produce overt toxicity, significantly reduced the percentage of PM capable of ingesting yeast [1].
• The European Food Safety Authority has established a tolerable daily intake of 250 ng kg(-1) body weight for the sum of dibutyltin, tributyltin, triphenyltin and dioctyltin [2].

High impact information on dioctyltin

• Cellular and molecular effects of di-n-octyltin dichloride on the rat thymus [3].
• The absorption, tissue distribution and excretion of di-n-octyltin dichloride in rats [4].
• Effect of orally administered dioctyltin dichloride on murine immunocompetence [5].
• Strain and sex differences in susceptibility of rats to dioctyltin dichloride [6].
• Studies were conducted to determine the period of immune system development that was most sensitive to perturbation by the known immunotoxicant di-n-octyltin dichloride (DOTC) [7].

Anatomical context of dioctyltin

• The effect of dioctyltin dichloride on the thymus and T-cell differentiation in the rat [8].
• The effect of four different alkyltins (trimethyltin, triethyltin, dibutyltin, and dioctyltin) on the metabolism of rabbit articular and growth-plate chondrocytes was investigated using a monolayer cell-culture system [9].

Analytical, diagnostic and therapeutic context of dioctyltin

• Oral administration of dioctyltin dichloride (DOTC) results in the production or release of factors which appear to prevent thymocyte maturation at an early stage [10].

References