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Chemical Compound Review

AC1MHYBN     dipotassium platinum(+2) cation tetrachloride

Synonyms: K2PtCl4, Dipotassium platinum chloride, dipotassium platinum(2+) tetrachloride
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Disease relevance of K2PtCl4

  • In contrast, K2PtCl4 and Rh-123 given i.p. produced very short growth delays at normal temperatures and these growth delays were not enhanced by hyperthermia [1].
  • When ascites cells collected from mice, pretreated in vivo with platinum compounds, were used, the enzyme assay showed that the inhibition is strongest in the case of cis-DDP and K2PtCl4 (about 90% inhibition) [2].

High impact information on K2PtCl4

  • The use of hyperthermia with CDDP, however, did not lower survivals in the SCC-25/CP cells even to the levels seen in the parent line at 37 degrees C. The cytotoxicities of K2PtCl4 and rhodamine 123 were essentially the same in the CDDP-sensitive and -resistant cells at all temperatures tested [3].
  • K2PtCl4 crosslinks CRE to CREB and TRE to JUN. The extent of crosslinking is about eight times greater than that observed with standard oligodeoxynucleotides and amounts to 30-50% of the efficiency of non-covalent association as estimated by gel-shift assays [4].
  • The crosslinking reaction is specific--a dumbbell oligonucleotide with six phosphorothioate groups introduced into the Sp1 recognition sequence could not be crosslinked efficiently to CREB or JUN proteins with K2PtCl4 [4].
  • The binding of TRE to CREB is not strong enough for effective detection by gel-shift assays, but the TRE-CREB complex is crosslinked efficiently by K2PtCl4 and can then readily be detected [4].
  • Potassium tetrachloroplatinate (K2PtCl4) inactivates dihydropteridine reductase from human brain in a time-dependent and irreversible manner [5].

Biological context of K2PtCl4


Anatomical context of K2PtCl4

  • The effect of the injection of K2PtCl4 into mice on gold-labelled concanavalin A (Con A) receptors on peritoneal macrophages was examined with an energy dispersive X-ray detector in an SEM [7].
  • Moreover, metallic dental drugs such as K2PtCl4 are used a dentine desensitizers [8].

Gene context of K2PtCl4


Analytical, diagnostic and therapeutic context of K2PtCl4


  1. Effect of hyperthermia on the action of cis-diamminedichloroplatinum(II), rhodamine 123(2) [tetrachloroplatinum(II)], rhodamine 123, and potassium tetrachloroplatinate in vitro and in vivo. Herman, T.S., Teicher, B.A., Chan, V., Collins, L.S., Kaufmann, M.E., Loh, C. Cancer Res. (1988) [Pubmed]
  2. The effect of some platinum compounds on the activity of the CTP synthetase of Ehrlich ascites tumor cells: in vitro and in vivo studies. Ganeva, R.L., Spassovska, N.C., Genchev, D.D. J. Inorg. Biochem. (1991) [Pubmed]
  3. Effect of hyperthermia on cis-diamminedichloroplatinum(II) (rhodamine 123)2[tetrachloroplatinum(II)] in a human squamous cell carcinoma line and a cis-diamminedichloroplatinum(II)-resistant subline. Herman, T.S., Teicher, B.A., Cathcart, K.N., Kaufmann, M.E., Lee, J.B., Lee, M.H. Cancer Res. (1988) [Pubmed]
  4. Crosslinking transcription factors to their recognition sequences with PtII complexes. Chu, B.C., Orgel, L.E. Nucleic Acids Res. (1992) [Pubmed]
  5. Inactivation of dihydropteridine reductase (human brain) by platinum(II) complexes. Armarego, W.L., Ohnishi, A. Eur. J. Biochem. (1987) [Pubmed]
  6. Effect of cis-platinum on the protein binding and pharmacokinetics of 67Ga-citrate. Sykes, T.R., Noujaim, A.A., Stephens-Newsham, L.G., NG, P.K., Lentle, B.C., Turner, A.R. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. (1986) [Pubmed]
  7. Determination of gold-labelled surface receptors on single cells by X-ray microanalysis. Peschke, T., Augsten, K., Sasama, F., Gabert, A. Journal of microscopy. (1989) [Pubmed]
  8. Mutagenicity of cadmium, platinum and rhodium compounds in cultured mammalian cells. Kanematsu, N., Nakamine, H., Fukuta, Y., Yasuda, J.I., Kurenuma, S., Shibata, K.I. Gifu Shika Gakkai zasshi = The Journal of Gifu Dental Society. (1990) [Pubmed]
  9. The effects of platinum complexes on seven enzymes. Aull, J.L., Allen, R.L., Bapat, A.R., Daron, H.H., Friedman, M.E., Wilson, J.F. Biochim. Biophys. Acta (1979) [Pubmed]
  10. Binding of platinum to human transferrin. Stjernholm, R., Warner, F.W., Robinson, J.W., Ezekiel, E., Katayama, N. Bioinorganic chemistry. (1978) [Pubmed]
  11. Effect of cis-diamminedichloroplatinum(II) and other platinum compounds on the RNA polymerase reaction. Ganeva, R., Spassovska, N., Genchev, D. Cytobios (1994) [Pubmed]
  12. Impact of K2PtCl4 on the structure of human serum albumin and its binding ability of heme and bilirubin. Trynda, L., Kuduk-Jaworska, J. J. Inorg. Biochem. (1994) [Pubmed]
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