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Chemical Compound Review

Ethanox 701     2,6-ditert-butylphenol

Synonyms: Isonox 103, Ethyl 701, CHEMBL281071, ACMC-1BU9F, CCRIS 5828, ...
 
 
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Disease relevance of AN 701

 

High impact information on AN 701

 

Biological context of AN 701

 

Anatomical context of AN 701

 

Associations of AN 701 with other chemical compounds

 

Gene context of AN 701

 

Analytical, diagnostic and therapeutic context of AN 701

References

  1. Synthesis and antiinflammatory activity of 2,6-bis(1,1-dimethylethyl)phenol derivatives. Tait, A., Parenti, C., Zanoli, P., Veneri, C., Truzzi, C., Brandoli, C., Baraldi, M., di Bella, M. Farmaco (1993) [Pubmed]
  2. Novel antiarthritic agents with 1,2-isothiazolidine-1,1-dioxide (gamma-sultam) skeleton: cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase. Inagaki, M., Tsuri, T., Jyoyama, H., Ono, T., Yamada, K., Kobayashi, M., Hori, Y., Arimura, A., Yasui, K., Ohno, K., Kakudo, S., Koizumi, K., Suzuki, R., Kawai, S., Kato, M., Matsumoto, S. J. Med. Chem. (2000) [Pubmed]
  3. Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity. Unangst, P.C., Connor, D.T., Cetenko, W.A., Sorenson, R.J., Kostlan, C.R., Sircar, J.C., Wright, C.D., Schrier, D.J., Dyer, R.D. J. Med. Chem. (1994) [Pubmed]
  4. Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors. Unangst, P.C., Shrum, G.P., Connor, D.T., Dyer, R.D., Schrier, D.J. J. Med. Chem. (1992) [Pubmed]
  5. S-2474, a novel nonsteroidal anti-inflammatory drug, rescues cortical neurons from human group IIA secretory phospholipase A(2)-induced apoptosis. Yagami, T., Ueda, K., Hata, S., Kuroda, T., Itoh, N., Sakaguchi, G., Okamura, N., Sakaeda, T., Fujimoto, M. Neuropharmacology (2005) [Pubmed]
  6. Effects of S-2474, a novel nonsteroidal anti-inflammatory drug, on amyloid beta protein-induced neuronal cell death. Yagami, T., Ueda, K., Asakura, K., Sakaeda, T., Kuroda, T., Hata, S., Kambayashi, Y., Fujimoto, M. Br. J. Pharmacol. (2001) [Pubmed]
  7. QSAR study of dual cyclooxygenase and 5-lipoxygenase inhibitors 2,6-di-tert-butylphenol derivatives. Ruiz, J., Pérez, C., Pouplana, R. Bioorg. Med. Chem. (2003) [Pubmed]
  8. Effects of dietary and in vitro 2(3)-t-butyl-4-hydroxy-anisole and other phenols on hepatic enzyme activities in mice. Rahimtula, A.D., Jernström, B., Dock, L., Moldeus, P. Br. J. Cancer (1982) [Pubmed]
  9. Effects of tebufelone (NE-11740), a new anti-inflammatory drug, on arachidonic acid metabolism. Weisman, S.M., Doyle, M.J., Wehmeyer, K.R., Hynd, B.A., Eichhold, T.H., Clear, R.M., Coggeshall, C.W., Kuhlenbeck, D.L. Agents Actions (1994) [Pubmed]
  10. Effect of probucol on the cytological and biochemical changes induced by adriamycin in Swiss albino mice. al-Gharably, N.M. Res. Commun. Mol. Pathol. Pharmacol. (1996) [Pubmed]
  11. Synthesis and biological evaluation of 2,6-di-tert-butylphenol hydrazones as 5-lipoxygenase inhibitors. Cuadro, A.M., Valenciano, J., Vaquero, J.J., Alvarez-Builla, J., Sunkel, C., de Casa-Juana, M.F., Ortega, M.P. Bioorg. Med. Chem. (1998) [Pubmed]
  12. 2,6-Di-tert-butyl-4-(2'-thenoyl)phenol(R-830): a novel nonsteroidal anti-inflammatory agent with antioxidant properties. Moore, G.G., Swingle, K.F. Agents Actions (1982) [Pubmed]
 
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