The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Mequinol     4-methoxyphenol

Synonyms: Mechinolo, Leucobasal, Mechinolum, Mequinolum, HQMME, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Mequinol


Psychiatry related information on Mequinol


High impact information on Mequinol

  • These results clearly demonstrated that while antioxidants causing proliferation in forestomach epithelium can markedly enhance carcinogenesis in this tissue, others displaying the same or greater potential for generating a hyperplastic response, like 4MP, can exert an inhibitory effect [2].
  • Identification by electron spin resonance of free radicals formed during the oxidation of 4-hydroxyanisole catalyzed by tyrosinase [7].
  • Among the p-alkoxyphenols studied, p-propoxyphenol was the most effective inhibitor of mouse R2 (IC50, 0.7 microM) and p-methoxyphenol was the least effective (IC50, 11 microM); p-ethoxy- and p-allyloxyphenol were intermediate [8].
  • Carcinogenicity of 4-methoxyphenol and 4-methylcatechol in F344 rats [9].
  • A combination of 4-hydroxyanisole (4HA) and all-trans retinoic acid (TRA) was found to synergistically cause moderate to complete depigmentation of Yucatan swine skin [10].

Chemical compound and disease context of Mequinol


Biological context of Mequinol


Anatomical context of Mequinol


Associations of Mequinol with other chemical compounds


Gene context of Mequinol


Analytical, diagnostic and therapeutic context of Mequinol


  1. Effects of organoselenium compounds on induction of mouse forestomach tumors by benzo(a)pyrene. el-Bayoumy, K. Cancer Res. (1985) [Pubmed]
  2. Modification of N-methyl-N'-nitro-N-nitrosoguanidine-induced forestomach and glandular stomach carcinogenesis by phenolic antioxidants in rats. Hirose, M., Fukushima, S., Kurata, Y., Tsuda, H., Tatematsu, M., Ito, N. Cancer Res. (1988) [Pubmed]
  3. Hydroxyanisole-induced regression of the Harding-Passey melanoma in mice. Dewey, D.L., Butcher, F.W., Galpine, A.R. J. Pathol. (1977) [Pubmed]
  4. Rifampicin inhibits the toxicity of pre-aggregated amyloid peptides by binding to peptide fibrils and preventing amyloid-cell interaction. Tomiyama, T., Kaneko, H., Kataoka, K., Asano, S., Endo, N. Biochem. J. (1997) [Pubmed]
  5. Comparison of the effects of 13 phenolic compounds in induction of proliferative lesions of the forestomach and increase in the labelling indices of the glandular stomach and urinary bladder epithelium of Syrian golden hamsters. Hirose, M., Inoue, T., Asamoto, M., Tagawa, Y., Ito, N. Carcinogenesis (1986) [Pubmed]
  6. p-methoxyphenol: chemical basis of stench of a female butterfly. Defense mechanisms of arthropods, No. 91. Eisner, T., Eisner, M. Naturwissenschaften (1990) [Pubmed]
  7. Identification by electron spin resonance of free radicals formed during the oxidation of 4-hydroxyanisole catalyzed by tyrosinase. Nilges, M.J., Swartz, H.M., Riley, P.A. J. Biol. Chem. (1984) [Pubmed]
  8. p-Alkoxyphenols, a new class of inhibitors of mammalian R2 ribonucleotide reductase: possible candidates for antimelanotic drugs. Pötsch, S., Drechsler, H., Liermann, B., Gräslund, A., Lassmann, G. Mol. Pharmacol. (1994) [Pubmed]
  9. Carcinogenicity of 4-methoxyphenol and 4-methylcatechol in F344 rats. Asakawa, E., Hirose, M., Hagiwara, A., Takahashi, S., Ito, N. Int. J. Cancer (1994) [Pubmed]
  10. Combination of 4-hydroxyanisole and all-trans retinoic acid produces synergistic skin depigmentation in swine. Nair, X., Parab, P., Suhr, L., Tramposch, K.M. J. Invest. Dermatol. (1993) [Pubmed]
  11. Ribonucleotide reductase in melanoma tissue. EPR detection in human amelanotic melanoma and quenching of the tyrosine radical by 4-hydroxyanisole. Lassmanm, G., Liermann, B., Arnold, W., Schwabe, K. J. Cancer Res. Clin. Oncol. (1991) [Pubmed]
  12. Chemoprevention of azoxymethane-induced colon cancer by ascorbylpalmitate, carbenoxolone, dimethylfumarate and p-methoxyphenol in male F344 rats. Rao, C.V., Rivenson, A., Kelloff, G.J., Reddy, B.S. Anticancer Res. (1995) [Pubmed]
  13. Percutaneous absorption of [3H]tretinoin and systemic exposure to mequinol after dermal application of 2% mequinol/0.01% [3H]tretinoin (Solagé) solution in healthy volunteers. Everett, D.W., Franz, T.J., Chando, T.J., Gale, P.J., Lehman, P.A., Schwarzel, E.H., Parab, P.V., D'Arienzo, C.J., Kripalani, K.J. Biopharmaceutics & drug disposition. (1999) [Pubmed]
  14. Arrest of cell cycle by inhibition of ribonucleotide reductase induces accumulation of NAD+ by Mn2+-supplemented growth of Corynebacterium ammoniagenes. Abbouni, B., Elhariry, H.M., Auling, G. Biotechnol. Lett. (2003) [Pubmed]
  15. Oxidation of monohydric phenol substrates by tyrosinase. An oximetric study. Naish-Byfield, S., Riley, P.A. Biochem. J. (1992) [Pubmed]
  16. Studies on the kinetics of oxidation of 4-hydroxyanisole by tyrosinase. Naish, S., Riley, P.A. Biochem. Pharmacol. (1989) [Pubmed]
  17. 4-Hydroxyanisole: human pharmacokinetics. Belcher, H.J., Barsted, C.G., Dawson, C.M. Pigment Cell Res. (1990) [Pubmed]
  18. Metabolic activation of 4-hydroxyanisole by isolated rat hepatocytes. Moridani, M.Y., Cheon, S.S., Khan, S., O'Brien, P.J. Drug Metab. Dispos. (2002) [Pubmed]
  19. The melanocytotoxic action of 4-hydroxyanisole. Riley, P.A., Sawyer, B., Wolf, M.A. J. Invest. Dermatol. (1975) [Pubmed]
  20. Mechanism of toxicity of the antimelanoma drug 4-hydroxyanisole in mouse hepatocytes. Schiller, C.D., Gescher, A., Jheeta, P. Eur. J. Cancer (1991) [Pubmed]
  21. Effects of dietary and in vitro 2(3)-t-butyl-4-hydroxy-anisole and other phenols on hepatic enzyme activities in mice. Rahimtula, A.D., Jernström, B., Dock, L., Moldeus, P. Br. J. Cancer (1982) [Pubmed]
  22. Specificity of growth inhibition of melanoma by 4-hydroxyanisole. Kulkarni, G.A., Nathanson, L. Pigment Cell Res. (1989) [Pubmed]
  23. Oxidation of monohydric phenol substrates by tyrosinase: effect of dithiothreitol on kinetics. Naish-Byfield, S., Cooksey, C.J., Riley, P.A. Biochem. J. (1994) [Pubmed]
  24. The combination of 2% 4-hydroxyanisole (Mequinol) and 0.01% tretinoin is effective in improving the appearance of solar lentigines and related hyperpigmented lesions in two double-blind multicenter clinical studies. Fleischer, A.B., Schwartzel, E.H., Colby, S.I., Altman, D.J. J. Am. Acad. Dermatol. (2000) [Pubmed]
  25. Cytotoxic effects of residual chemicals from polymeric biomaterials for artificial soft intraocular lenses. Chirila, T.V., Walker, L.N., Constable, I.J., Thompson, D.E., Barrett, G.D. Journal of cataract and refractive surgery. (1991) [Pubmed]
  26. Initial mushroom tyrosinase-catalysed oxidation product of 4-hydroxyanisole is 4-methoxy-ortho-benzoquinone. Naish, S., Cooksey, C.J., Riley, P.A. Pigment Cell Res. (1988) [Pubmed]
  27. Study of DT-diaphorase in pigment-producing cells. Smit, N.P., Hoogduijn, M.J., Riley, P.A., Pavel, S. Cell. Mol. Biol. (Noisy-le-grand) (1999) [Pubmed]
  28. Non-selective action of 4-hydroxyanisole on melanoma cells in vivo. Schwabe, K., Fichtner, I., Tschiersch, B. Pigment Cell Res. (1990) [Pubmed]
  29. Depigmentation therapy in vitiligo universalis with topical 4-methoxyphenol and the Q-switched ruby laser. Njoo, M.D., Vodegel, R.M., Westerhof, W. J. Am. Acad. Dermatol. (2000) [Pubmed]
  30. Relationship between 4-hydroxyanisole toxicity and dopa oxidase activity for three melanoma cell lines. Rodriguez-Vicente, J., Vicente-Ortega, V., Canteras-Jordana, M., Calderon-Rubiales, F. Melanoma Res. (1997) [Pubmed]
  31. Ultrastructural observations on the effect of 4-hydroxyanisole on normal human melanocytes in tissue culture. Breathnach, A.S., Diala, E.B., Gallagher, S.M., Porro, M.N., Passi, S. J. Invest. Dermatol. (1981) [Pubmed]
  32. Measurement of 4-hydroxyanisole in serum by direct injection high-performance liquid chromatography. Dawson, C.M., Belcher, H.J., Rainbow, S.J., Tickner, T.R. J. Chromatogr. (1990) [Pubmed]
  33. Tyrosinase autoactivation and the problem of the lag period. Naish-Byfield, S., Riley, P.A. Pigment Cell Res. (1998) [Pubmed]
  34. The combination of 2% 4-hydroxyanisole (mequinol) and 0.01% tretinoin effectively improves the appearance of solar lentigines in ethnic groups. Draelos, Z.D. Journal of cosmetic dermatology (2006) [Pubmed]
  35. The anti-initiator action of p-methoxyphenol phosphate upon the transformation of normal human embryo cells induced by benzo(a)pyrene. Găldean, D., Petraşincu, D., Stoicescu, D. Roumanian archives of microbiology and immunology. (1992) [Pubmed]
WikiGenes - Universities