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Gene Review

ALOX5  -  arachidonate 5-lipoxygenase

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Disease relevance of LOC404074


High impact information on LOC404074


Chemical compound and disease context of LOC404074


Biological context of LOC404074


Anatomical context of LOC404074


Associations of LOC404074 with chemical compounds

  • Circulating neutrophils, preincubated with rbIL-1 beta and stimulated with A23187, released significantly greater amounts of 5-hydroxyeicosatetraenoic acid and total 5-lipoxygenase metabolites when compared with control cells not incubated with rbIL-1 beta [6].
  • Within a class of structural analogs the activity against 5-LO, which was markedly improved as compared to that of the antipsoriatic drug anthralin, correlated well with the overall lipophilicity [14].
  • FPL 55712 and SKF 102922 and the 5-lipoxygenase inhibitor nordihydroguaiaretic acid (NDGA) had no effect on the response to antigen when used alone [18].
  • However, several derivatives of this series maintained 5-LO inhibitory activity but did not generate hydroxyl radicals and were not reactive with DPPH [11].
  • Treating silica with aluminum lactate or PVPNO significantly (P less than or equal to 0.05) reduced 5-lipoxygenase metabolite release and significantly (P less than or equal to 0.05) increased cyclooxygenase metabolite release [19].

Other interactions of LOC404074


Analytical, diagnostic and therapeutic context of LOC404074

  • Finally, Northern blot analysis revealed mRNA for 5-lipoxygenase to be present in human and bovine PMNs, but not in BRPs [22].
  • METHODS: Rat peritoneal leukocytes were isolated and the cellular 5-lipoxygenase activity was determined by HPLC after cell stimulation with calcium ionophore A23187 [16].


  1. Effect of inhibitors of eicosanoid metabolism on release of [3H]noradrenaline from the human neuroblastoma, SH-SY5Y. Vaughan, P.F., Murphy, M.G., Ball, S.G. J. Neurochem. (1993) [Pubmed]
  2. Characterization of arachidonic acid metabolism, superoxide production, and bacterial killing in bovine circulating neutrophils and elicited alveolar neutrophils. Heidel, J.R., Taylor, S.M., Laegreid, W.W., Silflow, R.M., Liggitt, H.D., Leid, R.W. J. Leukoc. Biol. (1989) [Pubmed]
  3. Influence of hypoxia on 5-lipoxygenase pathway in rat alveolar macrophages. Ohwada, A., Kira, S., Yamashita, T. Prostaglandins Leukot. Essent. Fatty Acids (1990) [Pubmed]
  4. Studies on lipoxygenase inhibitors. II. KF8940 (2-n-heptyl-4-hydroxyquinoline-N-oxide), a potent and selective inhibitor of 5-lipoxygenase, produced by Pseudomonas methanica. Kitamura, S., Hashizume, K., Iida, T., Miyashita, E., Shirahata, K., Kase, H. J. Antibiot. (1986) [Pubmed]
  5. Hypotheses regarding the role of pericytes in regulating movement of fluid, nutrients, and hormones across the microcirculatory endothelial barrier. Lonigro, A.J., McMurdo, L., Stephenson, A.H., Sprague, R.S., Weintraub, N.L. Diabetes (1996) [Pubmed]
  6. Functional studies of bovine alveolar neutrophils elicited with recombinant bovine IL-1 beta. Heidel, J.R., Sassenfeld, H.M., Maliszewdki, C.R., Silflow, R.M., Baker, P.E., Taylor, S.M., Leid, R.W. J. Immunol. (1990) [Pubmed]
  7. In vivo chemotaxis of bovine neutrophils induced by 5-lipoxygenase metabolites of arachidonic and eicosapentaenoic acid. Heidel, J.R., Taylor, S.M., Laegreid, W.W., Silflow, R.M., Liggitt, H.D., Leid, R.W. Am. J. Pathol. (1989) [Pubmed]
  8. Enhancement of plasma levels of biologically active leukotriene B compounds during anaphylaxis in guinea pigs pretreated by indomethacin or by a fish oil-enriched diet. Lee, T.H., Israel, E., Drazen, J.M., Leitch, A.G., Ravalese, J., Corey, E.J., Robinson, D.R., Lewis, R.A., Austen, K.F. J. Immunol. (1986) [Pubmed]
  9. Arachidonic acid metabolites in bFGF-, PDGF-, and serum-stimulated vascular cell growth. Dethlefsen, S.M., Shepro, D., D'Amore, P.A. Exp. Cell Res. (1994) [Pubmed]
  10. The role of cyclooxygenase and 5-lipoxygenase metabolites in potentiated endothelin-1-evoked contractions in bovine bronchi. Nally, J.E., Bunton, D.C., Martin, D., Thomson, N.C. Pulmonary pharmacology. (1996) [Pubmed]
  11. Antipsoriatic anthrones with modulated redox properties. 1. Novel 10-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of 5-lipoxygenase. Müller, K., Gürster, D., Piwek, S., Wiegrebe, W. J. Med. Chem. (1993) [Pubmed]
  12. QSAR study of dual cyclooxygenase and 5-lipoxygenase inhibitors 2,6-di-tert-butylphenol derivatives. Ruiz, J., Pérez, C., Pouplana, R. Bioorg. Med. Chem. (2003) [Pubmed]
  13. Nonsteroidal antiinflammatory agents, XVIII: C-5 functionalized 6,7-diphenyl-2,3-dihydro-1H-pyrrolizines as inhibitors of bovine cyclooxygenase and 5-lipoxygenase. Dannhardt, G., Kiefer, W. Arch. Pharm. (Weinheim) (1994) [Pubmed]
  14. Antipsoriatic anthrones with modulated redox properties. 2. Novel derivatives of chrysarobin and isochrysarobin--antiproliferative activity and 5-lipoxygenase inhibition. Müller, K., Leukel, P., Ziereis, K., Gawlik, I. J. Med. Chem. (1994) [Pubmed]
  15. Leukotriene A4, and not leukotriene B4, is the main 5-lipoxygenase metabolite released by bovine leukocytes. Sala, A., Testa, T., Folco, G. FEBS Lett. (1996) [Pubmed]
  16. pH-dependent regulation of leukocyte 5-lipoxygenase activity in inflammatory exudates by albumin. Benz, M., Werz, O., Jacob, R., Steinhilber, D. Inflamm. Res. (1997) [Pubmed]
  17. Inhibition of bovine lymphocyte response to phytohemagglutinin by a specific 5-lipoxygenase inhibitor. Atluru, D., Sayana, U., Yang, W.C., Schultz, R.D. Vet. Immunol. Immunopathol. (1987) [Pubmed]
  18. Characterization of the conjunctival vasopermeability response to leukotrienes and their involvement in immediate hypersensitivity. Gary, R.K., Woodward, D.F., Nieves, A.L., Williams, L.S., Gleason, J.G., Wasserman, M.A. Invest. Ophthalmol. Vis. Sci. (1988) [Pubmed]
  19. Diminished arachidonic acid metabolite release by bovine alveolar macrophages exposed to surface-modified silica. Englen, M.D., Taylor, S.M., Laegreid, W.W., Silflow, R.M., Leid, R.W. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  20. The antipsoriatic Mahonia aquifolium and its active constituents; I. Pro- and antioxidant properties and inhibition of 5-lipoxygenase. Müller, K., Ziereis, K. Planta Med. (1994) [Pubmed]
  21. Gene expression of factors related to the immune reaction in response to intramammary Escherichia coli lipopolysaccharide challenge. Bruckmaier, R.M. J. Dairy Res. (2005) [Pubmed]
  22. Biosynthesis of sulfidopeptide leukotrienes via the transfer of leukotriene A4 from polymorphonuclear cells to bovine retinal pericytes. Mcmurdo, L., Stephenson, A.H., Baldassare, J.J., Sprague, R.S., Lonigro, A.J. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
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